Preparative chromatography & SMB brochure
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Preparative Chromatography ...

Purication of Valuable Products Liquid Chromatography – the Preparative Approach Flüssigkeitschromatograe – der präparative Denkansatz The aim of preparative HPLC is to isolate the maximum amount of a certain product at a desired purity in a minimum of time. Preparative chromatography encompasses a broad range of purication processes, from the isolation of minimal amounts of pure substance for subsequent analytical investigation, all the way up to the continuous production of tons of pure product according to the principle of simulated moving bed (SMB) chromatography on an industrial scale....

repline P KNAUER Prepline Systems for Batch Chromatography KNAUER Prepline Systeme für die Batch-Chromatograe KNAUER Prepline systems can be operated either manually or with KNAUER software for fully automatic control. Prepline systems offer ow rates up to 1,000 ml/min, pressure stability up to 400 bar, various detection principles, optional solvent recycling and fraction collection based on either time (volume), signal level, signal slope, or even spectral similarity. Also possible is the adding together of different detector signals, optimization of fractionation conditions using only one...

Prepline Systems for Batch Chromatography The number of fraction collection positions can be increased at any time with the addition of cascading switching valves. Furthermore, nearly all of the fraction collectors currently on the market can be integrated and controlled. Die Anzahl der Sammelpositionen kann jederzeit durch Kaskadierung mit weiteren Schaltventilen erhöht werden. Andererseits ist auch die Einbindung praktisch aller auf dem Markt bendlichen Fraktionssammler möglich. Although other types of detectors can also be used, a xed wavelength detector (optionally integrated into the...

The SMB process enables the separation of binary mixtures by means of a simulated countercurrent between the solid and liquid phases. This is accomplished with a series of chromatography columns arranged in a ring. An eluent ow circulates through this ring. Two inlets (for feed and eluent) and two outlets (extract and rafnate) dene four separation zones. By continuously feeding sample and synchronously switching the columns against the eluent current, a countercurrent is achieved between the solid and liquid phases, leading to high purity of both target fractions. Das SMB-Verfahren...

SMB Systems for Continuous Chromatography KNAUER SMB systems are set up, tested and put into operation by a KNAUER specialist at the customer’s site. Users are also trained on how to operate the system at their own site. This service is included in the price of every SMB system. KNAUER CSEP® SMB-Systeme werden am Einsatzort aufgebaut, getestet und in Betrieb genommen. Die Anwender werden vor Ort am Gerät geschult. Dieser Service ist im Preis der SMBSysteme enthalten. Columns are not included in the SMB system as these are to be selected according to the specic application. KNAUER produces...

Prepline & SMB SMB processes are easily simulated and optimized with the use of the SMB_Guide® simulation software for Windows. By clearly displaying the internal and external concentration proles, the SMB_Guide® software makes it possible to study the inner processes of an SMB system. The SMB_Guide® software uses the system conguration specified and feed current to calculate all of the process parameters. In addition, the software can be used as an outstanding visual aid to understanding the SMB process (e.g. in employee training). Mit der Simulationssoftware SMB_Guide® für Windows lassen...

Prepline & SMB Technical Data SMB systems Technische Daten Flow Rates (max.) 50 ml/min Pump Type Smartline Pump 1000 Available pump heads 10, 50 ml/min Total Column Weight (max.) 20 kg (16 pieces) Column Dimensions (max.) 300 mm x 16 mm ID 1,000 ml/min Preparative Pump 1800 Flussraten (max.) 50 ml/min Pumpentyp Smartline Pump 1000 Verfügbare Pumpenköpfe 10, 50 ml/min Gesamtgewicht Säulen (max.) 20 kg (16 Stück) Säulendimensionen (max.) 300 mm x 16 mm ID CSEP® C9812 1.000 ml/min Preparative Pump 1800 100, 250, 500, 1.000 ml/min 120 kg (12 Stück) 1.000 mm x 32 mm ID oder 150 mm x 62 mm ID...