P owder and Particle P rocessing technolog y for the pharmaceutical I ndustr y O ne of our core business WE ARE YOUR The Hosokawa Micron Group is an international provider of equipment and systems serving a broad range of industries which includes chemical, minerals, pharmaceutical, polymer, food, blown film processing, confectionery and bakery, and specialised food. The Hosokawa Micron Group's broad range of powder and particle processing capabilities includes equipment and technologies for a variety of applications including: - Drying / Vacuum Drying / Active Freeze Drying - Size Reduction...

COMPETENT PARTNER KRO . MICRON . HOSOKAWA RIETZ . STOTT . VITALAIR . VRIECO-NAUTA Powder Processing Technology Expertise in Pharmaceuticals We can offer the pharmaceutical industry complete systems in the following areas: Hosokawa is a global operation with sales, The Hosokawa Group is a recognised world manufacturing and test centers throughout leader in powder processing technology - Mixing, Powder Blending and is highly innovative with developments - Vacuum Drying The pharmaceutical industry is an important coming out of its research centres based in - Size Reduction / Size Enlargement business...

Group Company Services System Design for CIP/SIP Many design standards are used, An increasing requirement for powder Special equipment designs, which facilitate processing systems in the pharmaceutical CIP/SIP are offered, such as special seal - cGMP directives industry is the need for them to meet CIP bearings, one piece construction of equipment - GAMP directives and SIP as this has several advantages: machined from a single piece of stainless steel - Reliable calibration, qualification and electropolished or finished surfaces down - ISPE Bulk Guide - Reproducibility of the cleaning parameters....

tailor-made solutions Detail Engineering Our philosophy is not to just offer a standard machine but to work alongside our customers and provide tailor-made solutions - System drawings to process tasks. With our in-house expertise, supported by major test centres throughout - Controls consultation (FDS/SDS/HDS) the world, we are able to supply solutions to even the most challenging processing - Structural steel engineering with static calculations - Piping & ductwork layouts - Acceptance inspections on subcontractors’ premises - Particle size analysis PROCESS AUTOMATION - Size reduction and micronisation...

Systems and Technologies Offered by Units Global Facilities Testing Facilities Hosokawa is a truly global operation with many operating units offering not only single materials are sent to our Test Centres for machines but complete systems. Research, machine/process evaluation. Many units development, process optimisation, system offer this facility and one of the largest and most comprehensive is with Alpine AG in Augsburg, Germany. The multi million dollar Test Centre completed in 1987 is one of the complete customer satisfaction. largest of its kind in the world. Hosokawa Alpine Hosokawa M...

Rental Machines Many of today's drugs and pharmaceutical in supplier test centres. However as a Group rental route is very useful and provides chemicals are toxic and cannot be handled we offer a rental machine service where customers with temporary production or safely away from their manufacturing base. specific equipment can be hired and tested pilot plant facilities. A further example of Frequently placebos or similar low risk on the customer's own site using Hosokawa Hosokawa's total commitment in satisfying compounds are used to evaluate machines supplied installation/instruction teams....

Mixing / Powder Blending The Hosokawa brands MICRON, HOSOKAWA RIETZ, SCHUGI and VRIECO-NAUTA are well-known for state-of-the-art solutions for mixing, powder blending and drying pharmaceutical powders. Therefore is it very well suited for formu- When we look at secondary pharmaceutical applications, Hosokawa Micron can provide lation plants. The Vrieco-Nauta CT vertical products we see a tendency for pharma- a wide range of mixing technologies. Both ribbon mixer is ideally suited for sterile ceutical companies to look for continuous batch and continuous mixing as well as low applications for...

In the pharmaceutical industry, especially used in secondary pharmaceuticals. Our interest, especially for free flowing powders when it comes to vacuum drying, we see Vrieco-Nauta conical screw dryer is well and filter cakes. Furthermore it is excellent a tendency towards multipurpose plants known for drying temperature-sensitive for sterilizing in place (SIP) and ensures in which it is relatively easy to switch from products. Given the fact that it can work optimal heat transfer for free flowing under vacuum condition, it enables drying even at ambient temperatures. Its well Thanks to flexibility...

Size reduction Nearly every stage of pharmaceutical manufacture involves some comminution with raw materials, additives and active ingredients processed to the required particle size. This means that a whole range of requirements needs to be fulfilled, from pure range between approx. 30 µm and 1 mm. A disagglomeration and coarse grinding right range of different equipment variants forms through to ultrafine comminution. Mikro ACM - CIP Design Air Classifier Mill Fine impact mills are suitable for the fineness the basis for universal application of this mill type. Modern classifier mills make...

Various types of jet mills are employed for micronising active ingredients. This type of impact comminution in a gas jet generates end fineness of between 1 and 30 µm. The classic exponent of this type of mill With the fluidised bed opposed jet mills, top size limitation. The carefully selected is the spiral jet mill which is characterised even micronisation of extremely "difficult" machine sizes range from laboratory and by its ease of operation, excellent cleaning products down to the µm range is possible. pilot applications up to production scale possibilities and the lack of rotating parts....