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XelPleX Multiplex Label-Free Interaction Analysis

XelPleX Multiplex Label-Free Interaction Analysis

XelPleX Multiplex Label-Free Interaction Analysis

Product catalog summary
XelPleX Multiplex Label-Free Molecular Interaction Platform
Overview: XelPleX is a platform developed by HORIBA Scientific that combines multiplexing capabilities with Surface Plasmon Resonance (SPR) technology to provide high-resolution kinetic profiles for molecular interactions. It is designed to enhance research efficiency and workflow in various applications, including ligand fishing, cell studies, and small molecule detection.
Key Features:
  • Multiplexing and Sensitivity: The platform allows simultaneous analysis of multiple interactions, significantly increasing throughput and reducing costs.
  • Real-Time Interaction Analysis: Utilizes SPR imaging to monitor binding events in real-time, providing insights into kinetics, affinity, specificity, concentration, and relative binding.
  • Fluidics System: The robust fluidics system is compatible with complex samples and designed for hands-off operation, accommodating various sample solutions.
  • Software Integration: Driven by EzSuite software, XelPleX simplifies operation and data analysis, offering features like real-time information retrieval, automatic data quality control, and instant reporting.
Applications:
  • Proteomics and Genomics: Suitable for protein and DNA analysis, offering tools for affinity profiling and concentration measurements without labels.
  • Drug Discovery and Development: Facilitates the ranking and screening of molecules, such as antibodies, based on affinity and kinetic rates.
  • Bioprocessing and Cell Science: Supports the optimization of experimental conditions and direct MALDI-MS characterization of captured analytes.
Advantages:
  • Efficiency: Saves time and resources by enabling high-throughput analysis and reducing the need for regeneration steps.
  • Flexibility: Compatible with a wide range of sample types and conditions, allowing for comprehensive interaction studies.
  • Data Management: EzAnalysis software provides easy data loading, analysis, and reporting, ensuring accurate and reliable results.
Contact Information: For more details, HORIBA Scientific can be contacted through various international offices or via their website.
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Catalog excerpts

XelPleX Multiplex Label-Free Interaction Analysis-1

Multiplex Label-Free Interaction Analysis Only Limited By Your Imagination

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XelPleX Multiplex Label-Free Interaction Analysis-2

Multiplex Label-Free Molecular In Accelerate your research and maximize your workflow with XelPleX combines the power of multiplexing (measuring multiple interactions simultaneously) and the sensitivity of Surface Plasmon Resonance, resulting high-resolution kinetic profiles. The revolutionary fluidics system and the integrated autosampler are compatible with a broad range of applications, such as ligand fishing in complex fluids, cell studies, small molecule detection, and protein and DNA analysis. Driven by the EzSuite software platform, XelPleX is simple to operate and is designed to maximize...

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XelPleX Multiplex Label-Free Interaction Analysis-3

nteraction Platform Instant information from real time display of images Binding events are followed in real time on the kinetic curves and also on the SPRi difference image. White spots on this image correspond to areas where binding has occurred – giving you a clear Yes/No answer to molecule detection and recognition. Biochip image before interaction Biochip SPRi difference image after interaction Cell Science Optimized fluidics system Drug Discovery and Development Working with complex samples like serum, plasma or cell lysates, in diagnostic research or drug discovery, is not an issue. The...

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XelPleX Multiplex Label-Free Interaction Analysis-4

Expand your Research Palette Instant affinity profiling using a single-injection step The single-injection step takes advantage of multiplexing by determining the affinity of analytes binding to different ligands using only one analyte concentration injection (no regeneration step required) - saving you time and samples. Direct comparison of wild-type (WT) and Mutant single-chain variable fragments (scFv) Optimization of immobilization concentratior Small molecules detection made easy The revolutionary optical and fluidics units obtain unsurpassed performance for high-sensitivity measurements....

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XelPleX Multiplex Label-Free Interaction Analysis-5

nd compare for the best using only one sensor chip Rank and screen your molecules during selection processes t immobilization concentrations, n the same sensor chip, and optimize al conditions of your interaction s many replicate spots as you wish to ent in the results. Multiplexing helps you to rank and screen molecules such as antibodies or aptamers according to affinity or kinetic rates easily and rapidly. Thanks to the SPRi-CFM printer, molecules can be immobilized from crude media to be compatible with your bioprocessing workflow. n and pH on the binding response of a small otein interaction...

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XelPleX Multiplex Label-Free Interaction Analysis-6

High-Performance Multiplexed Label-Free In n EzView software retrieves real time information through flow cell and SPRi difference images, and kinetics status. hundred ligands can be monitored simultaneously. as many negative controls as you wish. Accurate real time referencing brings more confidence to your results. Make decisions faster with instant information display Snapshot of the EzView control software Snapshot of the autosampler settings in EzView sequences can be programmed in the EzView software to automatically control the integrated autosampler. the running solution form up to 6...

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XelPleX Multiplex Label-Free Interaction Analysis-7

nteraction Instrument n Simply load your experiment data from the database, and perform your analysis in a few clicks. Collect and report data in a flash with EzAnalysis retrieves quantitative information and performs data quality control automatically. reporting of the experimental details (buffer, flow rate, temperature…), and of the analysis, to keep records of all your experiments. Quantitative analysis with EzAnalysis Data clouding of a 300 peptides array for epitope mapping (based on Scrubber) cleans and fits kinetics data to a 1:1 interaction model to calculate affinity and kinetic rates....

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XelPleX Multiplex Label-Free Interaction Analysis-8

Discover the Label-Free Platform from HORIBA Scientific This document is not contractually binding under any circumstances - Printed in France - ©HORIBA Jobin Yvon 02/2015 www.horiba.com/scientific [email protected]

 Open the catalog to page 8

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.