P-line
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P-LINE Heat Exchangers in the Pharmaceutical Industry

Heat Exchangers in the Pharmaceutical Industry Generation, storage, and distribution of WFI takes place in carefully designed systems. The required work parameters Water is the most commonly used raw material in the Water for injection (WFI) is produced from purified water pharmaceutical industry. Used not only as the main that has been treated to eliminate substances harmful to the ingredient in the production of medicines and vaccines, it human body. In the production of medicines it plays the role is also utilized for cleaning technological lines and rinsing extremely important. The WFI...

Heat exchangers in WFI generators Thermal distillation is the most common method used to obtain water for injection (WFI). WFI generator consists Production of injectable drugs Production of high purity inhalation drugs exchangers are used in the WFI generators for preheating, of one or more distillation columns in which the process • the microbiological purity of the WFI water. P-line heat regenerative heating, as well as for final condensation of of repeated evaporation and condensation of purified pure steam and cooling of generated water for injection. Production of advanced therapy...

WFI cold storage and distribution system WFI hot storage and distribution system The distilled water generated must be properly stored and distributed to the points of use. Another option is the system with only one In the cold water storage and distribution system, two P-line P-line exchanger installed. It then performs heat exchangers are installed. The first one is designed to Another method of storage and distribution is by keeping the water at a constant high both functions. Depending on whether cold keep the water temperature low (at 15-30˚C) and cool the water or technical steam...

In order to use WFI it must be cooled to the application temperature, which is usually 25°C to 45°C. If there are many points of use with the same temperature required, an additional circuit may be separated in the Another option is to place a heat exchanger just in front of the point of use (POU). system in which the P-line heat exchanger is installed. Its task is to cool the water to the application temperature. COLD WATER Figure 5. Diagram of the point of use (POU) with the P-line exchanger installed

Characteristics of the P-line heat exchangers Application of P-line heat exchangers P-line heat exchangers meet the highest requirements of the pharmaceutical industry. At the same time, they meet its stringent hygiene standards imposed by inspection bodies. They have been designed to minimize the risk of contamination and to ensure safe and sterile work. Pharmaceutical industry • Clean steam generation WFI storage and distribution systems • Shell side – water, steam, other consulted with the manufacturer • Food industry Dairy industry Brewing industry CERTIFICATES AND STANDARDS...

Construction of the P-line heat exchanger Tubes are connected to the tube sheets with pressure expanding method in which clean water under pressure up to 6000 bar is used. This eliminates the risk of damaging the internal surface of the tubes. Compensator Stainless straight tubes with a diameter of 8 mm (0.315 inch) or 12,7 mm (0.5 inch). Double tube sheet reduces the risk of media cross-contamination. Expanded tubes are then welded to the external tube sheet with orbital using welding a pure argon shield method. Certified silicone or Viton gaskets and triclamps, the clean side connections,...

Dimensions of P-line heat exchangers Technical parameters Dimensions Type Standard location of connections: K4 / K1 – inlet /outlet tube side (hygienic side) K2 / K3 –inlet /outlet shell side WORKING PARAMETERS Gaskets Technical drawing (service side) Position options Flow types *Parameters for P-050: max. temp. (Silicone) 140°C (284°F), min. temp. (Viton) -25 °C (-13 °F). All dimensions and technical data are approximate only and may be changed without further

Tube diameter Heat exchange area Tube side capacity TYPE 4P Connection type and material FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN 32676 Type A, SS FLANGE EN 1092-1 PN16 01B, TRI-CLAMP DIN...

P-line heat exchangers can be installed vertically or horizontally depending on the application and available space. Exemplar designation 4P - czteroprzepływowy poziomej Montaż w pozycji Montaż w pozycji pionowej Montaż w pozycji poziomej 1P - jednoprzepływowy Montaż w pozycji pionowej 1P – jednoprzepływowy 2P and 4P heat exchanger Montaż w pozycji pionowej Montaż w pozycji poziomej Montaż w pozycji pionowej Montaż w pozycji poziomej Montaż w pozycji pionowej 1P - jednoprzepływowy1P – jednoprzepływowy 2P Vertical mounting Montaż w pozycji pionowej 1P – jednoprzepływowy heat exchanger type...