P-LINE HEAT EXCHA N G ER S IN THE PH A R M AC E UT ICA L IND USTRY

Water is the most commonly used raw material place in carefully designed systems. The required the main ingredient in the production of medicines work parameters are usually determined and vaccines, it is also utilized for cleaning at the design stage and depend on the parameters technological lines and rinsing of packages. of the process for which a given medium is used. Water for injection (WFI) is produced from purified Sanitary aspects in the pharmaceutical industry are water that has been treated to eliminate substances Generation, storage, and distribution of WFI takes in the pharmaceutical...

Thermal distillation is the most common method used to obtain water for injection (WFI). WFI generator consists of one or more distillation columns in which the process of repeated evaporation and condensation of purif ied water takes place. As the process is carried out at a high temperature, this method gives complete assurance of the microbiological purity of the WFI water. P-line heat exchangers are used in the WFI generators for CONTACT LENSES preheating, regenerative heating, as well as for f inal condensation of pure steam and cooling of generated water for injection. DIAGRAM OF THE WFI...

WF I CO LD STOR AG E A ND D I STR I BUTI ON SYST E M The distilled water generated must be properly stored Another method of storage and distribution is by keeping the water at a constant high temperature of 176°F – 185°F. In the cold water storage and distribution system, two P-line The task of the P-line heat exchanger installed in this system heat exchangers are installed. The f irst one is designed to keep is to maintain the temperature using steam or hot water the water temperature low (at 59°F – 86°F) and cool the system. The second heat exchanger periodically heats the WFI water to sterilize...

WF I POI NTS OF U S E In order to use WFI it must be cooled to the application temperature, which is usually 77°F to 113°F. If there are many points of use with the same temperature required, an additional circuit may be separated in the system in which the P-line heat exchanger is installed. Its task is to cool the water to the application temperature. DIAGRAM OF THE POINT OF USE (POU) WITH THE P-LINE EXCHANGER INSTALLED Three-way valves Three-way valves Cold water Three-way valve Three-way valve Another option is to place a heat exchanger just in f ront of the point of use (POU).

P-line heat exchangers meet the highest requirements of the pharmaceutical industry. At the same time, they meet its stringent hygiene standards imposed by inspection bodies. They have been designed to minimize the risk of contamination and to ensure safe and sterile work. WFI COLD STORAGE AND DISTRIBUTION FOOD INDUSTRY DAIRY INDUSTRY HORIZONTAL AND VERTICAL MODELS AVAILABLE BREWING INDUSTRY SURFACES THAT COME INTO CONTACT WITH PURE MEDIUM HAVE BEEN POLISHED TO RA ≤ 0.5 µM ROUGHNES MANUFACTURED IN ACCORDANCE WITH CLEAN STEAM GENERATION

P -LINE D ES I G N TUBES ARE CONNECTED WITH TUBESHEETS using the pressure expansion method with pure pressurized water up to 6000 bar, which eliminates the risk od damaging their inner surface DOUBLE TUBESHEET reduces the risk of media mixing in case of potential leakage STAINLESS STRAIGHT TUBES with a diameter of 0.3 in or 0.5 in TRICLAMP CONNECTION TUBES ARE CONNECTED WITH THE EXTERNAL TUBESHEET the tubes, expanded using the pressure method, are welded to the external tubesheet using pure argon shield method CERTIFIED GASKETS made of silicone and Viton and clean side Triclamp connections

STANDARD LOCATION OF CONNECTIONS: K 3 ⁄ K 2   ― inlet / outlet shell side (service side) K 1 ⁄ K 4   ― inlet / outlet tube side (hygienic side) Flow types Tube diameter Heat exchange area SHELL SIDE WORKING PARAMETERS EXEMPLARY MEDIA TUBE SIDE * ARAMETERS FOR P-050: P MAX. TEMPERATURE SILICON — 284°F MIN. TEMPERATURE VITON — -13°F

Tube side capacity Connection size Shell side capacity Type and material of connections Type 1P FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP ASME BPE Type B, SS FLANGE ASME B16.5 #150 SORF, TRI-CLAMP...

EXEMPLAR DESIGNATION P-line heat exchangers can be installed vertically or horizontally depending on the application and available space. HORIZONTAL MOUNTING heat exchanger 2P HEAT EXCHANGER 4P HEAT EXCHANGER 1P – ONE-PASS 2P – TWO -PASS 4P – FOUR-PASS Pressure Vessel tube external gasket material PRODUCT LINE shell nominal VERTICAL MOUNTING ASME certif ication mounting position shell length