advanced technologies for Regenerative Medicine from Research to Clinical Injection & Perfusion Bioreactors Biosensing Total Solutions Support Regenerative Medicine Electrophysiology & Cell Biology Research Call to receive other catalogs of interest: Behavioral Research Harvard Apparatus Pumps Electroporation & Electrofusion Molecular Sample Preparation

NEW Breakthrough Products for Regenerative Medicine Regenerative Medicine Maintain Stem Cell Viability & Functionality with Cooled Cell Injection Pump NEW Products I NTRODUCTION INTRODUCTION Developed in the field, specifically for repeat injections of 1 µl to 100 µl of stem cells into live tissue. Easy-to-use, the NanoCool can be handheld or stereotaxic mounted for injections into live tissue while maintaining cell viability and functionality. The NanoCool cools cells to 18°C which results in a substantial reduction in O2 consumption as compared to 23°C. See page 13. 9. InBreath 3D Hollow Organ...

Imaging Technique, IRCI (Infrared Contrast Imaging) See page 76. NEW Products Visualize tissue and organ metabolic activity, vascularization of tissue and disease conditions in a bioreactor or during cell therapy. The new IRCI technology allows you to visualize events and evaluate treatment site conditions providing a new and powerful tool for regenerative medicine. I NTRODUCTION Developed with Leading Scientists and Surgeons! Dedicated Lung Bioreactor with Online Pulmonary Monitoring used in Successful Lung Regeneration and Transplant Proven and published whole organ bioreactor specifically...

Research Breakthroughs ■ i Do It Yourself Rugged Heparin Coating Kit Now In your lab you can coat glass, plastic and metal with a rugged heparin coating to reduce clot formation in bioreators, culture dishes, biomaterial and fluids. Lab Site Heparin Coating is simple to apply while the selective removal process allows easy ■ ■ Woven Synthetic Scaffold M aterial Accelerate tissue and cell engineering protocols with ready-made and precisi cnfi-nc sr.affolc ;-oe:s s ic i os B OLonpet ok = nri cell frierd y po yne- mah w tl- special configurations available. Wo'ks Airi mu ti - e I oioreactors. ■...

Table of Contents Company Information 4-5 Digital Gas Mixer Harvard Apparatus In the News 6-7 HPC-3, Hydrostatic Perfusion Chamber Injection and Perfusion 8 Cell Injection System Poster fold out 9-10 54 C-Pace Cell Culture EP Stimulator 55-57 Stimulator C 58 Stimulator CS for Isolated Cells 59 UI Ultra-Microliter Injection System 11 Synthetic Scaffold Material Pressure Controlled Injection System 12 Lab Site Heparin Coating 62 PHD ULTRA™ Gradient System 13 PHD Advanced Features of the PHD ULTRA™ 64 Biosensing Introduction 65 16 Family 63 Biosensing 15 Continuous Flow Syringe Pump Fast Bolus Injector...

INTRODUCTION I NTRODUCTION Harvard Bioscience companies have partnered with leading global scientists to provide specialized solutions for over 110 years…and we’re doing it again for Regenerative Medicine! Company Information Harvard Apparatus and the Harvard Bioscience family of companies are uniquely positioned to develop advanced instrumentation to accelerate Tissue Engineering and Cell Therapy treatments in Regenerative Medicine. From our origins in 1901, Harvard Bioscience Companies have worked closely with leading global researchers across many disciplines to produce clinical and research...

110 YEARS DESIGNING specialty physiology & electrophysiology apparatus, and cell physiology for small animals • Physiological sensors and devices • Low Volume Fluidics • Microscopic imaging chambers • Low Volume Sensors • Isolated ogran baths • Respiratory Mechanics • Physiological acquisition and control • Isolated Organ Baths • Macro and micro fluidic 2D reactors • 3D organ bioreactors • Infusion pumps • Cell Perfusion and Imaging • Environmental Control: pH, Temperature, Nutrition • Amplifiers, Filters and Data Acquistion in specialty physiology products with global scientific leaders: technology,...

Harvard Apparatus Harvard Bioscience’s Bioreactor Used to Produce a Synthetic Tissue-Engineered Airway Used in World’s First Successful Human Transplantation Harvar d Apparatus in the News I NTRODUCTION INTRODUCTION When Harvard Apparatus develops new products for a new market, we team up with leading scientists around the world. We use their input to develop new tools specifcally designed to help solve real research and clinical problems. We are proud and grateful to be part of the successful implementation of these new research devices. Some new tools have even been successfully used in human...

I NTRODUCTION in the News Harvard Bioscience 2010 Top Biotechnology Company in Massachusetts Harvar d Apparatus in the News Can We Live Forever? Replacing Body Parts. FOR PRODUCT INFORMATION 508.893.8999 How to Build a Beating Heart. [email protected] www.harvardapparatus.com 7

INJECTION & PERFUSION solutions for regenerative medicine: injection & perfusion Table of Contents NanoCool™ Poster fold out between 8-9 NanoCool™ Cell Delivery System Cooled Injection System to Maintain Cell Viability see pages 9-10 9-10 UI Ultra-Microliter Injection System 11 Pressure Controlled Injection System 12 13 PHD ULTRA™ Electrospinning Scaffolds 14 PHD ULTRA™ Continous Flow Syringe Pump I NJECTION & PERFUSION PHD ULTRA™ Gradient System 15 Fast Bolus Injector for Cell Therapy 16 Advanced Features of the PHD ULTRA™ Family 17-20 Harvard Apparatus Pulsatile Blood Pumps 21-22 Centrifugal...

INJECTION & PERFUSION NEW NanoCool™ Cell Delivery System Fixed 18˚C or Room Temperature for Optimal Cell Viability or Drug Delivery NanoCool Hand-held or Stereotaxic Mounted Injector I NJECTION & PERFUSION NanoCool Touch Screen Controller Foot-Pedal KEY FEATURES Infrared Profile of NanoCool Injection System Flow ramping to reduce injection site blowback Programmed methods for automatic recall of entire cell delivery protocol. Up to 100 methods stored for recall 2 year warranty. Certified with CE, UL, CB Scheme High accuracy delivery between 1.3 pl/min to 68 ml/min Preprogrammed bolus injection...