Hamilton Sensors for Biopharma
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Innovative Solutions for Process Analytics Biotech and Biopharma Upstream and Downstream

Continuous Innovation for Biotech and Biopharma More measurement parameters and less measurement error yield tighter process control Tomorrow’s Innovations Coming soon: new in-line sensors for common off-line measurements Extension of Single-Use portfolio to VCD, conductivity, and DO solutions. 2021 Solid-State CO2 Measurement An optical, maintenance-free sensor that streamlines CO2 monitoring and control in bioprocesses No preparation, sterilization, or calibration by customers; gamma sterilizable sensor capable of dry storage In-line Viable Cell Density Process optimization and control...

The Intelligent Sensor Revolution Over 95% of process engineers surveyed find value in using intelligent sensors Less than half of engineers felt they fully utilized their smart sensor. The key to getting the most out of your smart sensor is choosing the implementation that best fits your application. Hamilton offers two versions of smart sensors each equipped with our best-in-class measurement technology. Benefits of Replacing Analog with Intelligent Sensors 66% 89% Lower Maintenance Costs Lower Documentation Costs CONTROLLED L ABORATORY ENVIRONMENT MOBILE DIAGNOSTICS AUTOMATIC REPORT...

New Tools Dissolved CO2 CO2NTROL The first solid-state sensor designed to directly measure DCO2 in bioprocesses. The sensor provides a low maintenance, in-line measurement for the control of DCO2. This parameter is useful for optimizing cell viability, product yield, and when scaling a process up or down. Cell Density Sensors Incyte Arc (VCD) and Dencytee Arc (TCD) Real-time measurement of Viable Cell Density and Total Cell Density provides continuous data resulting in faster optimization of feeding and harvesting strategies. The top bioreactor manufacturers deliver reactors with Hamilton...

Seamless Scale-up to Production Sensors that last longer and require less maintenance Hamilton is known for high quality materials and craftsmanship that result in exceptional sensor life. With the introduction of the Arc sensors Hamilton took ownership of the measurement loop and pioneered advances in sensor calibration, troubleshooting, connectivity, and documentation. Start Up Hamilton assists you to better understand the functionality and use of your sensors with a familiarization demonstration. Trained service engineers are available to commission, qualify, and verify your sensor...

Product Offering Single-Use Sensors Reusable sensors are commonly used in single-use applications but require additional handling, sterilization, and insertion devices. Hamilton adapted these proven sensor technologies into single-use options that come from your single-use supplier: pre-installed, precalibrated, and gamma sterilized. Single-Use Sensor Element (wetted part) Compatible with Existing Single-Use Reactor Hamilton’s single-use solutions fit in a variety of different reactor styles and have already been evaluated for performance by many of the top single-use system providers. pH...

Single-Use Sensors Biopharmaceutical CPPs and KPIs SINGLE-USE FACILITY Media & Feed Preparation pH: OneFerm pH Conductivity: Conducell SU Media Prep Tank Media Prep Tank Media Prep Tank Bioreactor Bioreactor Wave Bioreactor Production (Stirred Bioreactors) pH: OneFerm pH DO: VisiFerm SU Viable Cell Density: lncyte SU Cell Expansion (Wave Bioreactors, Benchtop Bioreactors) Seed pH: OneFerm pH DO: VisiFerm SU Viable Cell Density: lncyte SU pH: OneFerm pH DO: VisiFerm SU Viable Cell Density: lncyte SU Fill & Finish Buffer Harvest Tank Capture Harvest pH: OneFerm pH Conductivity: Conducell SU...

Product Offering Measurement Parameters All relevant measurement parameters for BioPharma applications are part of the Hamilton portfolio. Reusable Sensors For more than 25 years, Hamilton has manufactured reusable sensors to meet the evolving needs of pharmaceutical and biotechnology upstream (USP) and downstream (DSP) customers. Our extensive product selection is certified to meet or exceed all FDA and GMP regulatory standards. USP Electrical Connectors Regardless of which electrical connector, analog or digital, Hamilton provides sensors with the compatible head.

Reusable Sensors Biopharmaceutical CPPs and KPIs # ; _ ■ . Every step of the biopharmaceutical process has specific requirements for sensors to monitor and control it precisely. The roadmap below shows the individual recommendations from the Hamilton portfolio.

Sensor Families EasyFerm Bio The EasyFerm Bio families of pH and ORP sensors are ideal for biotech applications, like fermentations, where autoclavations, steam sterilizations (SIP), and cleaning in place (CIP) procedures occur frequently. Available with the innovative Arc technology. VisiFerm Family BENEFITS ■     Stable measurement signals after steam sterilization, autoclaving, and CIP The VisiFerm is the first optical process sensor for the measurement of dissolved oxygen in biotech and pharma applications. It has significant advantages compared to classical Clark cells. It’s designed...

Cell Density Conducell 4UxF The Conducell 4UxF family of 4-pole conductivity sensors is suitable to measure a broad range of conductivities with excellent linearity. Typical applications are monitoring of CIP cleaning and chromatography. Available with the innovative Arc technology. Incyte Arc BENEFITS ■     Robust ■     All design for steam sterilization, auto clavation, and CIP wetted parts are FDA-compliant The Incyte sensors enable real-time, online measurement of viable cells in mammalian cell culture, yeast, and high-density bacterial fermentation. Online measurement allows detection...

Housings Retractex B Retractex B housings are designed for sanitary applications in biotechnology, food & beverage, and pharmaceutical industry and require low maintenance. The Retractex B with its patented HyCIP cleaning principle offers the best available cleaning efficiency for Ingold sockets. pH Buffers BENEFITS ■     All major process connections available: Ingold (G1¼), Triclamp, Varivent, DIN 11851 ■     Pneumatic ■     Integrated ■     Very or manual drive safety concept: no sensor—no insertion A complete range of buffer solutions provides never before achieved pH stability....