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Hamilton Optical DO Sensors for Biopharma

Hamilton Optical DO Sensors for Biopharma
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Hamilton Optical DO Sensors for Biopharma - 1

Optical Dissolved Oxygen Sensors DO Sensors for Biopharma

Hamilton Optical DO Sensors for Biopharma - 2

The Rise of Optical DO CONTINUOUS INNOVATION GUIDED BY USERS The introduction of the VisiFerm™ made it possible for biopharma process engineers to reap the established low maintenance benefits of optical sensing technology for the first time. Now, precise control of this critical process parameter still requires high frequency recalibration to achieve the commonly established verification tolerance and avoid costly deviations in GMP/FDA environments. The next generation VisiFerm™ incorporates breakthroughs in sensor and cap design to drastically reduce calibration frequency. Simplified...

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Hamilton Optical DO Sensors for Biopharma - 3

New Redesigned VisiFerm™ Higher robustness thanks to new electronics, security of supply. Reduced Calibration VisiFerm™ mA reduces the need for frequent calibration Single-Use Reusable sensing technology adopted for single use applications

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Hamilton Optical DO Sensors for Biopharma - 4

Analyzing the Impact FINDING HIDDEN CONTRIBUTORS TO MEASUREMENT ERROR Hamilton extensively investigated the effects of the bioprocess on measurement accuracy. Analysis of sensor aging, chemical attack, and physical damage yielded the necessary understanding for development of a next generation VisiFerm™ Arc which reduces the need for frequent calibration. Aging Photobleaching of the luminophore and aging of the electronics lessen measurement accuracy over time. Temperature Elevated temperature during SIP/CIP damages the luminophore and accelerates chemical impact. Calibration Failure to...

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Hamilton Optical DO Sensors for Biopharma - 5

Humidity Humidity is always 100% in dissolved oxygen measurement but can vary widely when calibrating in air, causing inaccuracies. Pressure Verification errors can result from uncontrolled calibration environments, which can change by as much as 80 mbar from the time of calibration to the time of verification. Calibration is Critical Up to 13.2% verification error can be introduced by changes in temperature, relative humidity, and atmospheric pressure from the time of calibration to the time of verification. Accounting for these environmental factors reduces the frequency of unnecessary...

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Hamilton Optical DO Sensors for Biopharma - 6

Next-Generation VisiFerm™ REDUCING THE IMPACT OF AGING AND TEMPERATURE Every application is unique, so standard compensation algorithms for the temperature effect of SIP and the aging effect of photobleaching have limited utility. Hamilton’s vision to fully overcome the influence of SIP/CIP and photobleaching required innovation in both sensor and cap design. This development effort resulted in the new VisiFerm™ Arc. Realization of the Vision The need for calibration is determined by a post-run verification. A relative verification error of 5% triggers calibration, while an error of 10%...

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Hamilton Optical DO Sensors for Biopharma - 7

►' “ MAKING A BETTER SENSOR Hamilton improved upon both sensor and cap design to create the most robust VisiFerm™ yet. Upgrading both key pieces allowed the VisiFerm™ Arc to have less frequent calibration, less measurement drift, and longer lifetime than previous optical DO sensors. Cap Stability New VisiFerm™ Arc caps have improved formulation and construction: • Strengthened luminophore • Enhanced luminophore • Stronger mechanical matrix for better chemistry for resistance stability for higher temperature stability to photobleaching process resilience VisiFerm™ Arc has the ability to...

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Hamilton Optical DO Sensors for Biopharma - 8

Take advantage of the VisiFerm™ Arc’s benefits with no changes to existing infrastructure. The sensor has all relevant certifications for GMP production environments and connects to existing installations. Arc Hamilton’s Arc technology streamlines access to all sensor information, including health, measurement, and settings. Measuring Principle Blue light excites a fluorescent dye (luminophore) in the sensor cap. In the absence of oxygen the energy is fluoresced as red light. In the presence of oxygen some energy is transferred to the oxygen molecule and less red light is emitted. The...

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Hamilton Optical DO Sensors for Biopharma - 9

Works LED Indicator jAt least one #|Sensor in • Ready to operate, no sensor sensor error warning state errors or warnings Connectivity Options VP8, RS485-ECS 100 backwards compatibility to existing installations* *with H0, H2 cap M12, 4-20mA, HART™ Optimized power consumption and a 2-wire configuration allow you to connect instantly to existing infrastructure. Bluetooth 5 Utilize the integrated benefits of Bluetooth 5 for a faster, more secure and robust sensor connection. Label Options Cap Options * H0 Cap The fastest response time and compatibility with most fermentation and culture...

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Hamilton Optical DO Sensors for Biopharma - 10

T ools for Predictive Maintenance Arc technology in the VisiFerm™ mA and RS485 pairs with the newest ArcAir software to automatically store all sensor activities, diagnostic data, and health indicators throughout the life of the sensor. Calibration, verification, and maintenance data are readily available to facilitate predictive maintenance planning. Automatic History Audit Trail Verification Reports Cap Change Recognition Calibration Reports

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Hamilton Optical DO Sensors for Biopharma - 11

VisiFerm™ Quality Indicators™ Sensor Installation of a new cap triggers automatic evaluation of the sensor electronics and updates the sensor health indicator Measurement Measurement quality is an indicator of the combined health of sensor and cap VisiFerm mA and RS485 with ArcAir now comes with a built-in audit log to track all changes to the sensor from a simple setting change to automatically recognized cap replacements Luminophore intensity is continuously monitored and used to calculate a cap health metric

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Hamilton Optical DO Sensors for Biopharma - 12

©2022 Hamilton Company. All rights reserved. Bluetooth is a registered trademark of Bluetooth SIG, Inc. All other trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. m 10082866/01 - d 08/2022 HAMILTON* Web: www.hamiltoncompany.com usa: 800-648-5950 Europe: +41-58-610-10-10 Hamilton Americas & Pacific Rim Hamilton Company Inc. 4970 Energy Way Reno, Nevada 89502 USA Tel: +1-775-858-3000 Fax: +1-775-856-7259 sales@hamiltoncompany.com Hamilton Europe, Asia & Africa Hamilton Bonaduz A.G. Via Crusch 8 CH-7402 Bonaduz, Switzerland Tel: +41-58-610-10-10...

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