Introduction
Real-Time CO2NTROL is a solid-state optical CO2 sensor designed to enhance bioproduction processes by providing real-time, maintenance-free, and in-line control of dissolved CO2 (DCO2). This sensor aims to increase product yield and improve consistency in process scale-up and scale-down.

Automated Control of DCO2
The sensor addresses issues of excessive CO2 accumulation, which can lower production quality by reducing intracellular pH, and excessive removal, which can slow cell growth and metabolism. Real-time control of CO2 is critical for optimizing yield, ensuring consistency across scales, and improving batch-to-batch reproducibility.

Impact on Process Performance
CO2NTROL optimizes yield by maintaining the optimal CO2 setpoint, ensuring consistency during scale-up and scale-down, and improving reproducibility and product titer. It addresses the challenges posed by varying mass transfer coefficients in different bioreactor sizes.

Direct vs. Indirect Measurement
Traditional electrochemical sensors measure DCO2 indirectly, requiring significant maintenance and calibration. In contrast, CO2NTROL uses a solid-state sensor that directly measures CO2 through optical absorption of MID IR wavelengths, offering better accuracy and lower maintenance costs.

Design and Features
The sensor is maintenance-free, with no liquids or replacement parts needed. It is compatible with autoclave, SIP, or CIP processes and can be installed in any orientation. The streamlined workflow eliminates the need for complex calibration procedures.

Integration and Compliance
CO2NTROL is part of Hamilton’s Arc Intelligent Sensor line, featuring embedded electronics for easy integration into control strategies. It offers wireless connectivity options and is compliant with biopharma application requirements, including GMP compliance.

Specifications
The sensor operates on the principle of optical CO2 absorption in the middle infrared range, with a measuring range of 5 to 1000 mbar. It is steam sterilizable, autoclavable, and operates within a temperature range of -10 °C to 60 °C.

Ordering Information
CO2NTROL is available in various lengths, with accessories such as cables and wireless converters available for enhanced functionality.