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Hamilton Cell Density Sensors

Hamilton Cell Density Sensors

Hamilton Cell Density Sensors

Product catalog summary
Overview: The document discusses the importance of real-time, on-line cell density monitoring in biopharmaceutical processes. It highlights the use of Cell Density Arc® sensors for measuring viable and total cell density, which is crucial for Process Analytical Technology (PAT) and advanced process control.
Key Sections:
1. On-Line Cell Density Monitoring: Emphasizes the necessity of in-situ measurements for effective process control, similar to pH and dissolved oxygen monitoring. On-line measurements provide immediate data, allowing for real-time process adjustments and improved process understanding.
2. Viable Cell Density (VCD): Describes the use of permittivity measurements to monitor viable cell density. This method is sensitive to changes in cell physiology and helps in timing process-specific actions for optimal yield.
3. Total Cell Density (TCD): Explains the measurement of total cell density using the Dencytee Arc® sensor, which measures turbidity at near-infrared wavelengths. This method is effective during the growth phase and provides reliable data for process control.
4. PAT Solutions: Discusses the integration of various sensors, including pH, dissolved oxygen, and CO2, to enhance process monitoring and control. The document also highlights the benefits of real-time data for process optimization and automation.
5. Sensor Technology: Details the Incyte® and Dencytee® sensors' working principles, focusing on their ability to provide real-time data for viable and total cell density measurements. The sensors use capacitance and turbidity measurements to deliver accurate and immediate data.
6. Process Connectivity: Describes the integration of Arc sensors with process control systems using various communication protocols. The ArcAir® software facilitates sensor configuration, data recording, and process monitoring.
7. Implementation and Support: Highlights Hamilton's expertise in guiding the implementation of these sensors, offering support for data collection and analysis to ensure robust product evaluation.
Conclusion: The document underscores the advantages of real-time cell density measurement in improving yield, reducing costs, and enhancing product quality through continuous process optimization.
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Catalog excerpts

Hamilton Cell Density Sensors-1

On-Line Data Real-Time Decisions Cell Density Sensors

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Hamilton Cell Density Sensors-2

On-Line Cell Density Monitoring Measure Cell Density in Real-Time for Immediately Actionable Data and Automated Process Control On-line, or in-situ, measurement is the pinnacle of process monitoring and necessary for true process control as evidenced with control of pH and dissolved oxygen, common for most biological processes. In fact, many parameters can be monitored but those directly related to cell physiology are typically time consuming off-line measurements that provide only a reactionary window into the past. Cell Density Arc® sensors provide a means for directly measuring viable and...

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Hamilton Cell Density Sensors-3

Your Way for On-Line Measurement Incyte VIABLE CELL DENSITY (VCD) TOTAL CELL DENSITY (TCD) The Incyte® sensor enables real-time, on-line measurement of viable cells without need for sampling. Typical applications include mammalian cell culture, yeast, and high-density bacterial fermentation. The measurement is independent of changes in media, microcarriers, dead cells, and debris. Online measurement of viable cells makes it possible to detect events and respond in real time without off-line sampling. The Dencytee Arc® sensor performs on-line measurement of Total Cell Density in solution. The...

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Hamilton Cell Density Sensors-4

Innovate with Real-Time Cell Density Measurement Viable Cell Count (e6/mL) VCD Measurement with Incyte Arc® Incyte® and Dencytee® in Action Viable Cell Density Measurement is Best for Cell Culture: From increasing yield to shortening process time, the real power of in-line measurement is in your hands. As shown in the examples below, ask yourself what you could do with continuous process data. Mammalian Cell Culture Insect Systems Process Understanding: High Cell Density Bacteria Fermentation Filamentous Applications Expand your PAT capabilities with viable and total cell density and gain process...

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Hamilton Cell Density Sensors-5

Wide Range of Integrations with No Transmitter. Don’t Waste Valuable Workspace. INTEGRATED MICRO-TRANSMITTERS Arc sensors integrated microtransmitter amplifies the sensor signal for direct connection to the control system. Sensor configuration occurs via USB or wireless Bluetooth? Arc sensors save space and cost with their integrated microtransmitters. Factory calibration and diagnostic data are saved within the sensor, so you can always check a sensor’s performance, even mid-run. Built-in memory also provides back-up storage of process data for ensured reliability. ARCAIR® ArcAir® is Hamilton’s...

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Hamilton Cell Density Sensors-6

Leverage Hamilton Expertise Utilize Hamilton’s Application Team and Proven Evaluation Process for Rapid Implementation and Robust Product Evaluation SETUP A team of experts guide implementation with quick-start settings chosen for your process. COLLECTION Our Application Team is readily available to answer questions while you collect robust data. ANALYSIS Data is analyzed toward your specific objectives with the addition of insights based on an existing knowledge base of applications.

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Hamilton Cell Density Sensors-7

Contact your local Hamilton Area Sales Manager or Google Incyte Arc and Dencytee Arc #totalcelldensity #viablecelldensity ©2022 Hamilton Company. All rights reserved. All other trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. Lit. No. 10148821/00 - 03/2022 HAMILTON Web: www.hamiltoncompany.com usa: 800-648-5950 Europe: +41-58-610-10-10 Hamilton Americas & Pacific Rim Hamilton Company Inc. 4970 Energy Way Reno, Nevada 89502 USA Tel: +1-775-858-3000 Fax: +1-775-856-7259 [email protected] Hamilton Europe, Asia & Africa Hamilton Bonaduz A.G. Via...

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