OPTO-SEMICONDUCTOR PRODUCTS LCOS-SLM for high-power lasers ELECTRON TUBE PRODUCTS Compact MCP assembly with +/-5 kV floating operation SYSTEMS PRODUCTS Streak camera with 100 fs temporal resolution

Cover Story ORCA-Flash4.0 LT + Scientific CMOS camera Rich data that provides new insights W-VIEW GEMINI-2C Image splitting optics ORCA Spark Digital CMOS camera ImagEM X2 EM-CCD camera ORCA-Flash4.0 V3 Scientific CMOS camera

Live cell imaging How does the brain work? Super-resolution microscopy New technology, new insights? Micro- and nanoscale events How do cells grow? In vivo & in vitro Is there a correlation between in vitro and in vivo performance? Cellular voltage Is there a better way to measure voltage at the cell membrane? Maximum intensity projections How can we shape the illumination to reveal the most information? Life in 4 dimensions How can we enable faster 3D imaging?

Cover Story We are delighted to introduce Hamamatsu's newly updated Life Science Camera Community Our community contains not only product information, latest news and events but also a wealth of information on the various imaging techniques such as live cell imaging, super-resolution and much more. The Living Image is a site dedicated to celebrating life science imaging, brought to you by Hamamatsu. At the Living Image we present exciting research stories at the forefront of microscopy and imaging, highlighting the advances each work makes to biology and discussing technologies that make the...

Cover Story Live cell imaging How does the brain work? Super-resolution microscopy New technology, new insights? Micro- and nanoscale events How do cells grow? How does a collection of individual neurons coordinate to make a muscle move and understand what a scent means all in the same few milliseconds of time? Cell signaling and clathrin-mediated endocytosis. Lipid rafts and molecular motion within the membrane. Movement of organelles within a cell and cell division. Protein organization and co-localization. Virus entry. Many of cell and molecular biology’s most critical events are occurring...

Digital CMOS Board Level Camera High resolution scientific imaging with 12 megapixels The core of the C13949-50U camera is the scientific image sensor, an advanced CMOS detector that simultaneously achieves high resolution, fast readout speeds and low noise. Readout noise High resolution Frame rate 15 frames/s (Full resolution) See page 31 to find out more about our new Digital CMOS Board Level Camera.

OPTO-SEMICONDUCTOR PRODUCTS R&D INTERVIEW APPLICATION REPORT 8 An innovative step to expand X-ray inspection applications 14 FISHing of gut microbiota with the NanoZoomer S60 A sealed type MFX with a transmission target is now on the scene! COMPANY NEWS SERVICE 12 The United Nations Global Compact 34 Global Exhibitions 2017 and 2018 12 Technology Days 2017 - Chasing Photons in X-ray and Infrared 35 Hamamatsu Photonics K.K. Sales Offices

R&D Interview An innovative step to expand X-ray inspection applications A sealed type MFX with a transmission target is now on the scene! X-ray inspection is a technique that provides information about the internal structure of objects such as semiconductor devices, which cannot be seen from the outside. Its accuracy depends on the MFX or microfocus X-ray source used to generate X-rays. We have just unveiled a new model MFX that combines the advantages of the “open type” having high accuracy and a “sealed type” offering easy maintenance. This new model is a sealed type MFX using a “transmission...

Interviewees (from the left) Kazutaka Suzuki: Manuf. #5, Electron Tube Division ( main development of MFX) Motofumi Tanaka: Manuf. #5, Electron Tube Division (development of sealed type MFX) Chihiro Yagi: Manuf. #5, Electron Tube Division (general management in development of MFX) Satoshi Ito: Business Promotion Dept., Electron Tube Division (sales) Irradiation window Reflection target X-ray focus Transmission target Success! We downsized the electron lens by applying our advanced power supply technology Irradiation window Mechanism of X-ray generation Ito: That large size is what makes it difficult...

essential for in-line inspections. The increasing demand for 100 percent testing of smartphone components and batteries has tremendously boosted the need for making X-ray inspections. The advent of our new sealed type MFX will minimize the difference in performance between the sealed type and open type, so we can now expect dramatic new transitions in the X-ray inspection market. When did you first get the idea to utilize the advantages of both sealed and open types? Ito: Sales of our MFX series started in 1993. Since then we have worked hard to develop both the sealed type and open type. Around...

1C Highly compatible with in-line inspection needs for electronic components Have you had an opportunity to hear customer opinions or suggestions at the development stage? Ito: There were a lot of demands from customers for a new model which integrates the advantages of the sealed type and open type. We also had customers saying: "I want to try it out right away!" even though it was still under development. So before releasing the new model, we asked customers more often than usual to evaluate the prototype and give us as much feedback as possible to reflect their needs in the final product. Tanaka:...

Company News The United Nations Global Compact Hamamatsu Photonics K.K. has signed the United Nations Global Compact proposed by the United Nations and become a registered participant on August 18, 2017. The United Nations Global Compact is a voluntary initiative of the United Nations to encourage companies and organizations to engage in the establishment of a global framework to achieve sustainable growth and act as good members of society by demonstrating responsible and creative leadership. Participants support the Ten Principles in four areas of human rights, labour, environment and anti-corruption...