RAPID, RELIABLE ADSORPTION PROCESSING Process Scale Adsorbent Cartridges for Pharmaceutical Purification

Features and Benefits • Proven cartridge design assures simple, reliable adsorption processing • Fixed porous media eliminates handling and safety issues associated with loose carbon • Large adsorbent capacity in small area foot print increases product recovery and reduces solvent requirements • Extended flow path provides more contact time and better adsorption performance

Ecosorb® Process-Scale Adsorbent Cartridges Until recently the use of activated carbon was largely processing. Graver Technologies, producer of Ecosorb® avoided in API manufacturing due to handling and safety Products, recognized the need for a better way to use issues. Filtration and chromatography products converted activated carbon at the bench, in pilot, kilo labs and to incorporate activated carbon have provided handling commercial operations. The result is a new family of and safety improvements for pilot scale use but done little cartridge adsorbent products we believe will improve to...

Applications Uses for E-PAK cartridges include the removal and E-PAK lab cartridges are generally used for processing recovery of precious metal catalyst, reaction-by-products samples of 50 ml or more. Testing in Gravers’ laboratory and color from synthetic reaction mixtures and natural has shown good correlation between the performance products. Compared to loose media, pre-packed of lab, pilot and commercial size cartridges (Figures 2A columns and stacked disc filters E-PAK products provide and 2B). A typical setup for testing E-PAK lab cartridges High Adsorption Capacity and Flow Rate; Increased...

ACTIVE ADSORBENT AVAILABLE PRODUCTS/SIZES MEDIA WEIGHT ECOSORB C-SERIES EQUIVALENT 16.5 cm Diameter • 12.5 cm High • 25 cm High Code 8 Custom formations available. Pilot scale cartridges provide a convenient means for confirming scale-up considerations and or producing kilo quantities of API's and intermediates.

E-PAK FLOW RATE COMMERCIAL SCALE PROCESSING To meet commercial processing requirements E-PAK cartridges can be operated in parallel for increased capacity. E-PAK cartridges provide rapid processing for manufacturing operations needing to process batch sizes of >10,000 liters or can be adapted for continuous operation using a duplex design. For applications where precious metal catalyst recovery CARTRIDGE SIZE DIAMETER X HEIGHT (CM) FLOW RATE PRESSURE DROP P (PSIG) WITH w/1 CPS FLUID CONTACT TIME (MINUTES) is an important consideration E-PAK cartridges can be thoroughly flushed with a low volume...

Cartridge Housing Selection Graver Technologies offers a series of semi custom fabricated cartridge housings for operation of 1 to 12 cartridges. The table below shows guidelines and details for standard housing configurations. For additional information on filter housings and industrial scale housing retrofit kits please request a copy of Graver bulletin GTX 325 and or contact Graver Technologies. Filter housing options: ASME or PED pressure rated/stamped, conductive casters, KALREZ® gaskets, type and size of inlet & outlet, connections -wetted and non wetted surface finish. For the most current...

CORPORATE HEADQUARTERS (U.S.A.) Graver Technologies, LLC 200 Lake Drive Glasgow, Delaware 19702 Tel: 302.731.1700 Fax: 302.731.1707 E-Mail: [email protected] Website: www.gravertech.com CUSTOMER SERVICE Tel: 302.731.3516 Fax: 302.369.8356 Superior Products & Global Reach Whether your business is around the corner or around the world, Graver Technologies can support you with superior products and services. Our ion exchange, adsorbent, filtration, and membrane products deliver exceptional performance in some of the harshest process environments in North America, Europe, Asia, the Pacific Rim,...