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GEA Granulation Technologies

GEA Granulation Technologies
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'«cce?, Cfcertr iitcrrr. mtccr, uu,,, GEA Granulation Technologies Multipurpose Process Solutions for Solid Dosage Forms engineering for a better world

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GEA Group is a global specialist in solid and liquid dose technology. Combining trusted technology with an ongoing programme of innovation and price/performance leadership, GEA has a long history of expertise and an unparalleled depth of experience in the fields of batch and continuous granulation, drying, pelletizing and coating, contained materials handling, tablet compression, pharmaceutical freeze drying, fermentation and liquid formulation, separation, homogenization and cell disruption. With manufacturing and technology centres all over the world, GEA provides the services that the...

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Granulation Technologies Why Granulation? In the pharmaceutical industry, tablets remain the most commonly produced oral dosage form; most ﬁne pharmaceutical compounds require granulation to improve their ﬂowability and processing properties prior to tableting. As such, granulation, which allows primary powder particles to adhere and form granules, is one of the most important unit operations in drug manufacturing. A number of diﬀerent granulation and compression technologies are available to pharmaceutical manufacturers, all of which have individual strengths and weaknesses depending on...

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Granulation Techniques Which Granulation Process? In the pharmaceutical industry, wet and dry granulation are most common processes employed in the production of solid dosage forms, although in certain situations, direct blending is also possible. Given the importance of granulation in the production of oral dosage forms and the technique’s extensive use in the industry, it’s essential to understand the principles and options, which are summarised below. Dry Granulation: This process is used to form granules without using a liquid solution, because the product to be granulated may be...

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Choosing the Right Granulation Process Choosing the Right Granulation Process GEA supplies engineering services, complete production/process plants and standalone oral solid dosage machines to customers in the pharmaceutical industry. GEA provides proven solutions for the most challenging dosage forms such as oncology drugs, multiple unit pellet system (MUPS) tablets, eﬀervescents and multilayer pellets. Also, as experts in containment, we oﬀer the largest variety of solutions for contained processing, based on our unrivalled experience in containment risk analysis to identify the most...

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Choosing the Right Granulation Process Single Pot Processing Fluidized Spray Drying (FSD) A mixer/granulator that dries granules in the same piece of FSD produces granules from a liquid in a one-step process. One equipment without discharging is commonly known as a option is to produce the active in the primary production step single pot processor (or one-pot processor). A single pot as granules, so that it only requires blending with excipients processor is, in essence, a high shear granulator enhanced suitable for direct compression for secondary processing. This with various integrated...

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Continuous Granulation As a result of various regulatory initiatives to improve product quality and to reduce the risk of product failure, there is a huge interest in continuous processing. A typical system has three modules: a wet high shear granulation module, a segmented dryer module and a granuleconditioning module. In the granulation module, dry ingredients are dosed individually or premixed into the continuous high shear granulator. After a small dry mix section, the granulation liquid is added, so each particle receives the same amount of liquid. The whole wet granulation process...

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Granulation Technologies GEA has supplied shear granulator plants and granulation and drying process expertise to various industries for more than a century, and to the pharmaceutical industry in particular for more than 50 years. This includes small capacity systems designed for R&D as well as industrial size plants for the batch and continuous production of pharmaceutical compounds under cGMP conditions. With both top and bottom drive granulators available, we can help you to select the technology that is most suitable for your product and process. The GEA high shear mixer and granulators...

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PMA™ High Shear Mixer Granulators The PMA™ family — PMA™ classic, PMA-Advanced™ and PharmaConnect™ — provides total flexibility in system design and capacities of 1-1800 L. It is the ultimate in versatility, with modular options for blending, high shear granulating and wet pelletizing. The design maximises product processing and handling containment. User-selected standard process modules are combined with advanced automation and cleaning-in-place (CIP) systems to create custom solutions that meet individual needs. Key features include the following: • process containment • complete ease of...

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UltimaGral™ UltimaGral™ High-Shear Mixer Granulators With the Gral™ range, GEA pioneered the market for top-driven high shear mixer granulators. Still in demand after numerous product upgrades, this state-of-the-art processing workhorse is available with a wide range of bowl capacities to suit any production requirement. The equipment is built to comply with current cGMP standards and is recognised by companies worldwide as being low maintenance, high quality, robust and reliable. Designed for production-scale functionality, special mixing tools are available for specific applications, as...

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PharmaConnect™ PharmaConnect™ R&D High Shear Granulation This innovative system provides a unique benefit to the pharmaceutical development industry, integrating a single control unit with a diverse range of process modules. Based upon GEA's class-leading PMA™ and Gral™ granulation technologies, the PharmaConnect™ provides the user with the ability to process batches from as little as 100 g, right up to 25 kg or more, all from a single control system. Standard module capacities are set at 1, 3, 5, 10, 15, 20, 30 and 60 L (with each unit being geometrically scalable). Critically, each of...

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