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Catalog excerpts
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Successful Tableting Supplement Continuous Tableting engineering for a better world A-Type Tooling
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Operational excellence For more than a hundred years, our innovation, driven by our passion for excellence, has pioneered tablet compression technology, allowing pharmaceutical and industrial companies to prosper, produce extraordinary products and change people’s lives. Our innovations include a unique technology that independently and simultaneously measures and controls both tablet weight and hardness, and a weight control system that provides increased sensitivity at lower forces. Our presses offer an extended dwell time — up to 300% — resulting in higher outputs and enhanced...
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Continuous pharmaceutical manufacturing means that ingredients are continuously being fed in at one end of the production unit and end product is continuously being generated at the other. Continuous manufacturing is more cost-effective than traditional batch processing, as the amount of product generated effectively depends on how long the equipment is run for. Drugs can therefore be manufactured according to demand. Critically, in continuous manufacturing, all process and quality parameters are constantly monitored and controlled at each stage of the process with integrated process...
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Tablet presses have always operated continuously. Until now, however, because of regulatory restrictions and the fact that granules were delivered to the press in batches, they have mainly been used in batch mode. Both of these hurdles to continuous tableting have been removed in recent years. GEA MODUL™ tablet presses are an essential component of the company’s ConsiGma™ continuous processing line for solid dosage forms. ConsiGma™ is an innovative technology, unique to GEA, that meets both the demands of the regulatory authorities and pharmaceutical companies for continuous manufacturing...
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Taking a blue sky powder-to-tablet approach to pharmaceutical manufacturing, ConsiGma™ offers continuous oral solid dosage granulation, drying and tablet compression in a single production line. The ConsiGma™ continuous tableting line (CTL) is a multipurpose platform that has been designed to transfer powder into coated tablets in development, pilot, clinical and production volumes in a single integrated unit. The ConsiGma™ system is designed for plug flow, first-in first-out production (avoiding back mixing), providing consistent quality and allowing for the inline control of critical...
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The ConsiGma™ concept enables small amounts of product to be processed and developed quickly and efficiently. And, once a formulation has been optimized, it can be reliably reproduced in pilot, clinical or production batches, simply by running the machine for longer, avoiding scale-up problems and the lengthy validation processes that hinder bringing new products to market faster. Environmental Benefits Combining processes into a single machine means reduced space requirements, smaller buildings, smaller cleanrooms, less waste and less consumption of power and raw materials. ConsiGma™...
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CONSIGMA™ 1 maximum flexibility and simplicity during R&D and formulation development The ConsiGma™ 1 is a mobile laboratory scale continuous granulator with an optional fluid bed dryer segment for early research and development work. Designed for maximum flexibility and simplicity during R&D and formulation development, the ConsiGma™ 1 is capable of processing batch sizes starting from 500 g with less than 10 g of product in process. The optional fluid bed dryer can accommodate batch sizes of 500-1500 g. As direct transfer of the granulation parameters to the production-scale ConsiGma™ CTL...
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The ConsiGma™ CDC for direct compression is the latest addition to the ConsiGma™ family, our continuous portfolio of cost effective, compact, high yield manufacturing systems with embedded quality control. This compact, all-in-one, tablet production line for direct compression (DC) formulations (approx. 4 x 4 x 3 m) means that the dispensing area, blending area and intermediate storage requirements are a thing of the past. Up to six ingredients can be fed separately via specially developed LIW feeders and, thanks to the integration of the feeding, blending and compression operations,...
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The ConsiGma™ coater from GEA is a revolutionary, new, high performance tablet coating technology that accurately deposits controlled amounts of coating materials on tablets — even if they are extremely hygroscopic or friable. Designed specifically to be an integral part of the ConsiGma™ continuous tableting lines, the ConsiGma™ coater is able to process small quantities of tablets at very high rates, offering improved heat and mass transfer. Presenting a paradigm shift in tablet coating, this new type of coater entrains tablets in a cascading movement that enables greater fluid application...
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The MODUL™ Range of Tablet Presses A Range of Opportunities and Solutions THE MODUL™ RANGE sets new standards in efficiency, productivity and reliability The MODUL™ Q rotary tablet press sets new standards in efficiency, productivity and reliability. Like its predecessors, the MODUL™ Q features GEA’s Exchangeable Compression Module (ECM). However, the next generation version of the ECM has fewer parts, is even more convenient to use and offers a higher level of containment performance. The feeder height and ejection finger height can be set outside the machine, with the ECM positioned on...
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Key Features • MULTI-CONTROL 5 (MC5) control system, offering multiple compression modes • Overall equipment effectiveness (OEE) monitoring • Single and bilayer compression • Freely adjustable dwell time at pre- and main compression • Easy to assemble, operate and clean • Compact footprint (1 m2). Designed for full-scale production, the MODUL™ Q represents the very best of GEA’s compression technology in an equally attractive casing, bringing next-generation tableting technology to the pharmaceutical industry. Manufacturers are welcome to bring their most challenging formulations to...
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