Clarification of Viral Vectors
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VIRAL VECTORS DEPTH FILTRATION FOR VALUABLE LIQUIDS. SINCE 1938.

Clarification of Viral Vectors The Background To manufacture viral vectors, two approaches generally are adopted for culturing purposes: scale-out of adherent-cell systems based on 2D planar technologies and scale-up of 3D suspension cell cultures in different types of bioreactors. The industry appears to favor cells adapted to suspension cultures (e. g. HEK293), which can successfully grow in serum-free media and thus provide an enhanced safety profile and reduced cost of goods. Downstream processing is aimed at eliminating contaminants originating from host cells and culture media. The...

The Solution Optimized solutions for viral vector clarification The PURADISC® BIO SD system isthe state-of-the-art technology for alluvial filtration. It is based on depth filters that capture contaminants in their three-dimensional matrix. PURAFIX® depth filters are low in extractable ions and by adding filter aid, such as diatomaceous earth, the blocking of the filter can be avoided. The following table shows all available variants of PURADISC® BIO SD. Product Size Description Batch size Best use PURACAP® BIO SD 2" Capsule Lab scale PURACAP® BIO SD 5" Capsule Small pilot scale PURACAP®...

Filter Presses and Module Housings PURADISC® BIO SD is used in combination with a pressure housing DISCSTAR® BIO SD. FILTROX offers the corresponding pressure housings for the different module sizes and filter presses for filter sheets. DISCSTAR® BIO SD 12" short support system DISCSTAR® BIO SD 12" double support system NOVOX® sheet filter