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Solutions for the Production of Solids
Solutions for the Production of Solids
Fette Compacting provides integrated solutions for the production of solid dosage forms, focusing on efficiency and quality. Their approach combines advanced technology with a holistic process partnership, supporting clients from initial formulation to commercial production.
- Quality by Design and Qualified Experts-Database: Emphasizes embedding quality into the design process using Quality Target Product Profile (QTPP), Critical Quality Attributes (CQAs), Critical Material Attributes (CMAs), and Critical Process Parameters (CPPs) to ensure robust production processes.
- Research and Development Solutions: Offers R&D solutions that accelerate the transition from lab to production, including the use of emulators and the F Lab 10 for powder compaction analysis.
- Production Equipment: Details equipment options like the FE CPS for continuous direct compression and the FE Series for flexible production, including the i Series and p Series for versatile and efficient production capabilities.
- Containment Solutions: Outlines safety-focused containment solutions for processing active ingredients, including models like the FE55 and FE75 with containment packages.
- Process Optimization and Support: Provides ongoing production support, process optimization strategies, and regulatory support to ensure efficient and compliant manufacturing processes.
Fette Compacting positions itself as a leader in the tablet production industry by providing integrated solutions that combine advanced technology with expert consulting, ensuring efficient and high-quality solid dosage production.
Focuses on material analysis, formulation optimization, and production transfer, supporting from initial material characterization to GMP-compliant production.
- Analyzes physical and chemical properties of raw materials for scalable manufacturing.
- Studies powder compaction behavior to optimize formulations.
- Uses High-Performance Liquid Chromatography (HPLC) for precise analytics in research and quality control.
- Conducts feasibility studies to evaluate formulations and processes early, minimizing risks.
- Defines safe parameter ranges for stable production processes.
- Develops models for process control and batch traceability.
- Establishes optimal control parameters to ensure production stability.
- Safely transfers processes from lab to GMP production environments.
- Provides holistic support for tablet presses and production lines, including commissioning, maintenance, and process optimization.
- Offers global technical support ensuring machine availability through remote and on-site assistance.
- Features a digital spare parts catalog and logistics network for quick and accurate parts supply.
- Optimizes machine utilization and ROI through fleet management strategies.
- Offers machine modernization and refurbishment as cost-effective alternatives to new purchases.
- Integrates all process steps into a single machine, enhancing efficiency and quality in pharmaceutical solid dosage production.
- Features compact design, fast product changeovers, and real-time monitoring with embedded Process Analytical Technology (ePAT).
- Throughput capacity ranges from 5 to 400 kg/h, depending on the configuration.
- Enables in-line monitoring of critical quality parameters during production using near-infrared sensors for blend and tablet uniformity.
- Real-time monitoring prevents batch rejection and minimizes waste.
- Offers high performance, flexibility, and process reliability in tableting.
- Models like FE35, FE55, and FE75 cater to different production needs, from small batches to high-volume outputs.
- Technical specifications include various punch types, compression forces, and tablet outputs, ensuring adaptability to diverse production requirements.
- i Series: Includes models like F10i, F20i, and F30i, designed for small to large batch productions with varying output capacities.
- p Series: Includes models like F10p, F20p, and F30p, suitable for small to large batch productions, offering features like double-layer tablet manufacturing.
- Compression force ranges from 0 to 100 kN depending on the model.
- Turret rotation speed varies between 5 to 120 min–1.
- Dimensions and weight vary by model, with the largest models weighing up to 4,600 kg.
- Electrical supply parameters include an operating voltage of 400 – 480 V and power consumption ranging from 9 kW to 17 kW.
- Fully automated, software-controlled cleaning process designed to minimize downtime and ensure safety for operators and the environment.
- Available in models like 1090i WiP, 2090i WiP, and 3090i WiP, catering to various production scales.
- Offers a global training program to support teams across the production lifecycle, enhancing machine efficiency and reducing downtime.
- Process Reliability: Early mastery of critical material properties through R&D solutions.
- Machine Versatility: Optimal tablet presses for various applications, from small batches to continuous processing.
- Flexibility: Easy-to-clean machines designed for quick changeovers, adhering to the Quality by Design principle.
- Strategic Approach: Customized strategies for flexible batch production and efficient continuous manufacturing.
- Lifetime Partnership: Support from formulation development to process optimization.
- Vitamins and Minerals: Precise dosing and economical series production.
- Chewable Tablets and Confectionery: High-output processing of demanding textures and sticky blends.
- Multi-Layer and Special Shapes: Custom geometries for brand differentiation.
- Effervescent and Combination Products: Reliable processing of complex, moisture-sensitive formulations.
- Botanicals: Robust processes for naturally varying raw materials.
Provides contact details for Fette Compacting's offices across Europe, Asia, North America, Latin America, and Africa, ensuring global support and accessibility.
The publication is protected by copyright, and technical changes may occur. It is printed on 100% recycled paper.
Catalog excerpts
Solutions for the Production of Solids One Partner. Maximum Efficiency. Solutions for the Production of Solids MF | 1
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COMPACTING together ** from lab to production 4 together - from lab to production Faster time-to-market with a holistic process partnership Qualified Experts-Database The foundation for efficient production of solids 8 R&D Solutions: The Reliable Path to Market Readiness Data-driven. Scalable. Safe. Understanding powders before production begins Process development close to production Production-related galenics for direct scale-up Our formula for your efficient research Better together - from lab to production For more than 75 years, Fette Compacting has been redefining precision in industrial...
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Faster time-to-market with a holistic process partnership Research and Development <§§><w Production Extended range of services along the process chain: Formulation Development Knowledge Base QED > Concentrated expertise: Access to more than 75 years of tableting experience > Confident decisions: The digital foundation for your well-informed process planning Formulation Development > Formulation consulting: Expert support backed by pharmaceutical expertise > Understand your materials: Precise characterization of your active ingredients and excipients Process Development > Test without risk: Emulator-based...
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Quality is not a coincidence — it is built into the design Excellent tablets are the result of systematic planning, which is why we embrace Quality by Design (QbD). By understanding all key production elements and material properties, we ensure that quality is not just checked at the end of production, but is embedded in the product from the very beginning.. Qualified Experts-Database by Fette Compacting For robust processes, we examine the interactions between Critical Material Attributes (CMAs), Critical Process Parameters (CPPs), and Critical Quality Attributes (CQAs). By understanding how...
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R&D Solutions: The Reliable Path to Market Readiness Data-driven. Scalable. Safe. Powder Compaction Analyzing Unit F Lab 10 Understanding powders before production begins The path from the first formulation idea to industrial production is complex and often fraught with risk. Critical questions arise: Will the powder behave on the highperformance machine the same way as in the lab? Are the processes stable and economically scalable? To avoid costly errors in tableting, full transparency into material properties is essential. The F Lab 10 characterizes the compaction behavior of powders with minimal...
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The scale-up from lab to production is a critical phase. Simulators reach their limits here because they can only replicate complex physical effects to a limited extent. Our emulators, by contrast, faithfully reproduce the physics and mechanics of production-scale machines - without tying up valuable capacity on your high-performance equipment. The advantages: You reliably validate critical parameters and analytical methods, save expensive active ingredients, minimize scale-up risks, and transfer the data directly to the production line. Precision in Continuous Dosing The FE CPS Process Emulator...
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The 102i tablet press is the ideal solution for lab operation and galenical development. All parameters determined in the lab can be directly transferred to production-scale machines. Number of layers max. tablet output max. tablet output Pmax® max. tablet diameter Die (D) / Segments (S) Number of punch stations Punch type Tablet output units/h Max. compression force 1* Max. compression force 2* Max. tablet diameter Max. filling depth 1st layer** Pitch circle diameter Turret rotation speed min. max. (laboratory operation) Die diameter Die-/segment height Punch shaft diameter Punch length Upper/lower...
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R&D Services Our formula for your efficient research With Fette Compacting’s R&D Services, you expand your capabilities in pharmaceutical development. Whether you face a specific challenge or want to optimize your entire development process: Our experts support you with in-depth know-how and cuttingedge infrastructure. We flexibly support you wherever you need it: from the first material analysis through the development and optimization of formulations to reliable transfer into production. You benefit from fast results, proven strategies, and a collaborative partnership that frees up your resources...
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Services for Production Close to your machine – just like you Our Production Services provide holistic support for your tablet presses and production lines – from seamless commissioning through ongoing maintenance to data-driven process optimization. Complex products and stringent regulatory requirements place the highest demands on operations, so you need a partner who understands your machines down to every detail. With worldwide support, fast spare parts supply, and predictive maintenance, we ensure that your machines operate at peak efficiency, in full regulatory compliance and with maximum...
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FE CPS The new standard in Continuous Direct Compression Pharmaceutical solid dosage production is undergoing a paradigm shift: The transition from classic batch processing to Continuous Manufacturing delivers considerable efficiency and quality gains. Until now, complex systems with large footprints have been a barrier to adoption. This is precisely where Fette Compacting steps in, rethinking Continuous Direct Compression from the ground up. With the FE CPS, we introduce a groundbreaking solution based on a rigorous Quality by Design approach. Instead of large mixing tanks and complex transfer...
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ePAT Integrated process analytics for Continuous Manufacturing and batch production Whether you produce continuously with the FE CPS or use classic batch processes: Our embedded Process Analytical Technology (ePAT) enables seamless in-line monitoring of critical quality parameters during ongoing production. Near-infrared (NIR) sensors monitor powder blend homogeneity (Blend Uniformity) and Tablet Uniformity, detecting quality deviations in real time. This prevents the late rejection of entire batches, minimizes waste, and represents a decisive step toward Real-Time Release. Blend Uniformity The...
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