ErtelAlsop The First Name in Liquid Filtration Micro-Cap™ Depth Filters Standard Features • Plastic • Metal • Filter Optional Features • Optional Stand Applications • Small batch fermentation • Removal of cell debris • Cell culture clarification • Serum clarification • Plasma clarification • Small Volume Parenteral prefiltration • Decolorization • Endotoxin Removal Scalability The Micro-Cap™ series offers four choices of surface area to fit your requirements, 22.5 cm2, 550 cm2, 1,100 cm2 (0.0055 m2 ,0.11 m2) and 2,200 cm2 (0.22 m2). With a range of batch sizes from 50 ml to 100 liters, the Micro-Cap™ is ideally sized for laboratory use and scale up for full production is easy. Ask for ErtelAlsop’s Filter Sizing Data Spreadsheet to assist you with the scale-up calculations. Performance The Micro-Cap™ incorporates ErtelAlsop’s Micro-Media®, Micro-Media XL, or Micro-Clear™ series of filter media, to provide the optimum balance of dirt holding capacity and throughput. The available media is capable of particle retention from 15 microns to 0.2 microns and all grades exhibit a strong positive zeta-potential allowing for retention of particles smaller than the mechanical pore size of the media. The MicroClear™ series is formulated with activated carbon for decolorization. Reliability As with all ErtelAlsop depth filter products the Micro-Cap™ provides consistency and lot to lot traceability all in an easy-to-use, selfcontained and completely disposable laboratory filter capsule. All Micro-Caps™ must pass a pressure hold test before being released, and the Micro-Cap™ meets all applicable USP requirements including the Class VI Plastic. Filter Media As with all ErtelAlsop plate and frame filter press models, media is available for any application and/or operating condition, and is chosen based on your specific operating conditions, the performance required by the filtering media, and criteria given to us by you and/or by sample processing we do in our lab. ErtelAlsop offers the widest varieties of filter media including 100% cellulose pads, cellulose and diatomaceous earth pads, cellulose and Celpure® diatomaceous earth pads, cellulose and perlite pads, and cellulose and activated carbon pads. All filter pads are manufactured to very high standards for a wide range of applications in the pharmaceutical, chemical, cosmetic, electric utility and food and beverage markets. ErtelAlsop also offers a Validation Guide to assist in the validation of its filter pads in your process. The Validation Guide contains information regarding raw materials, extractables, and general information about the product. The combination of ErtelAlsop “P” grade filter pads and ErtelAlsop’s BioClean™ plate and frame filter press design, can help to simplify your depth filtration validation now more than ever. ErtelAlsop • PO Box 3358 • Kingston • NY • 12402 • ErtelAlsop.com • 845.331.4552 • Fax 845.339.1063 Laboratory Filters Micro-Cap™ Disposable Laboratory Filters are perfect for use in product development, small batch processing and intermediate scale-up studies. Micro-Caps™ are available in three sizes and with a broad range of ErtelAlsop’s high performance filter media. This provides maximum flexibility in process development and scaleup. No stainless steel housings are required which eliminates the need for cleaning validation. Connect the Micro-Cap™ directly to the downstream processing components, minimizing operator exposure to the product.

XL Series Media Unparalleled Performance ErtelAlsop’s Micro-Media® XL Series combines 75 years of experience with the highest performing filter aid available on the market, Celpure® to provide optimal filter performance. This series of media exhibits 2-5 times the throughput of competitive media while maintaining equivalent or better product clarity (See Figure 1). Incorporation of XL Series media in the Micro-Cap™ allows for the use of this media through. Micro-Clear™ Carbon Media* Carbon is used as a loose powder in many pharmaceutical applications for decolorization and depyrogenation. ErtelAlsop’s...

Micro-Cap™ Specifications M od e l 01 Mo d e l 5 E nclo sure P oly p rop y le ne Po l y pro py l e n e C o nne ct ions 1/ 4” - 3/ 8” b a r b f e ma le s lip le ur 3 / 4 ” Sa n i t a r y C l a m p D ra in & Vent Seals N/ A Si l i c o n e Ve nt Lue r Loc w ith Ca p F ilte r Area 22. 5 c m 2 P re ssure LImit 30 P S I Vo lum e 14 ml 0.5 oz Me dia Diamet er 60 mm 2.36 inches 3.49 in2 550 cm2 8 5 in 2 Micro-Cap™ Specifications M od e l 10 Mo d e l 2 0 E nclo sure P oly p rop y le ne Po l y pro py l e n e C o nne ct ions 3/ 4” S a nita r y Cla mp 3 / 4 ” Sa n i t a r y C l a m p D ra in & Vent Seals...