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3D-BIOPLOTTER® STARTER SERIES

3D-BIOPLOTTER® STARTER SERIES
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The 3D-Bioplotter® Process Unique to the 3D-Bioplotter® 4th Generation 3D-Bioplotter® Manufacturer Series 4th Generation 3D-Bioplotter® Developer Series 4th Generation 3D-Bioplotter® Starter Series Key Features of the 3D-Bioplotter® 3D-Bioplotter Materials Application: Bone Regeneration Application: Drug Release Application: Cell/Organ Printing & Soft Tissue Fabrication Other Applications

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3D Bioprinting - The Future Is Now! The EnvisionTEC 3D-Bioplotter® system has been used since 2000 for a variety of medical applications. Most research done to date using our machines has been in the pre-clinical setting, yielding many publications by pre-eminent scientists from the materials science, neuroimaging, and toxicology disciplines. In the clinical setting, patient CT or MRI scans are used to create STL files to print solid 3D models which can then be used as templates for implants. Tissue Engineering and Controlled Drug Release require 3D scaffolds with welldefined external and...

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3D non-woven with interconnecting pores A simple process: A liquid, melt, paste or gel is dispensed from a material cartridge through a needle tip from a 3-axis system to create a 3D object. One single requirement: The material to be used must, through a physical or chemical reaction, solidify. A world of possibilities: The widest range of materials of any 3D printing technology can be processed.

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Unique to the 3D-BIOPLOTTER® Process Uses raw materials (powder, pellets, etc.) without requiring a preprocessed filament. Medical-grade materials can be used. Designed for use in a sterile biosafety cabinet with built-in sterile and particle filters for the input compressed air. Materials are kept in sterilizable cartridges, thus avoiding touching the machine: easier to clean and sterilize. Each customer can create their own processing parameters. Not locked to any proprietary materials, customers can choose their prefered vendors, as well as required medical grades, mixture compositions...

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Manufacturer Series • Designed both as a tool for advanced Tissue Engineering research, as well as for use in a production environment. • Capable of using all hardware and software options of the 3D-Bioplotter Series. • Includes heated platform and sterile filter, recommended for Cell Printing / Organ Printing.

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EnvisionTEC - German Precision

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4th Generation 3D-Bioplotter® Developer Series • Designed for research groups new to the field of Tissue Engineering, as well as for specialized use, where the limited capability may still meet requirements. • Consisting of the same basic hardware and software as the Manufacturer Series, but with reduced functionality regarding camera and park positions. • Not upgradable to the same capability of the Manufacturer Series.

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EnvisionTEC - German Precision

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4th Generation 3D-Bioplotter® Starter Series • Designed for research groups new to the field of Tissue Engineering with few requirements in parallel material processing and automation. • Consisting of the same basic hardware and software as the Manufacturer & Developer Series, but lacking modular capability and platform temperature control. • Not upgradable to the same capability of the Developer or Manufacturer Series.

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EnvisionTEC - German Precision

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Key Features 3D-Bioplotter® A new user management allows users to both share projects, materials and patterns, as well as have their own separate set of files for improved overview and security. Input of outer shapes through STL files. Multi-part and multi-material capable through the use of an automatic tool changer and multiple print heads. Generation of volume support structures for complex shapes. Database of inner patterns (user-editable) in the controlling software, avoiding requiring patterns in the STL files. Complex inner pattern with straight lines, zig-zag shapes and wave forms...

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Individual temperature control of each printing head, both in the parking positions, as well as during printing Temperature curves with up to 5 set points and waiting times. Complete control of all printing parameters (temperature, pressure, speed, etc) through the software. Photographic log of the full platform for each layer available for verification of error-free object interior after printing. (Manufacturer Series only) Mid-print measurement of strand dimensions using the built-in camera. (Manufacturer Series only) Automatic Platform Height Control for Petri Dishes, Well Plates, as...

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Key Features 3D-Bioplotter® Low Temperature Print Head (0 °C to 70 °C) with disposable PE cartridges. High Temperature Print Head (30 °C to 250 °C) with reusable stainless steel cartridges. UV Curing Head (365 nm). Needle cleaning station, with automatic cleaning before and during the print project available. Luer Lock needle tips, 0.1mm to 1.0mm inner diameter available. Automatic recalibration of park position coordinates in extensively used 3D-Bioplotters (Manufacturer & Developer Series only). LOG file creation after project completion with all relevant data. Footprint (L x W x H): 976...

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All materials are delivered with processing parameters and instructions of use (sterilization, pre-processing, post-processing, etc.).

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Sample Papers: • Li, J. P., et al. „The effect of scaffold architecture on properties of direct 3D fiber deposition of porous Ti6Al4V for orthopedic implants." Journal of Biomedical Materials Research Part A 92.1 (2010): 33-42. • Haberstroh, K., et al. „Bone repair by cell-seeded 3D-bioplotted composite scaffolds made of collagen treated tricalciumphosphate or tricalciumphosphate-chitosan-collagen hydrogel or PLGA in ovine critical-sized calvarial defects." Journal of Biomedical Materials Research Part B: Applied Biomaterials 93.2 (2010): 520-530. • Zhang, J., et al. „3D-printed magnetic...

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Application: Drug Release Thermoplasts PCL PLLA PLGA Phase Transition Sample Papers: • • Kammerer, M., et al. „Valproate release from polycaprolactone implants prepared by 3D- bioplotting.“ Die Pharmazie-An International Journal of Pharmaceutical Sciences 66.7 (2011): 511-516. Yilgor, P., et al. „An in vivo study on the effect of scaffold geometry and growth factor release on the healing of bone defects.“ Journal of tissue engineering and regenerative medicine 7.9 (2013): 687-696. Yuan, J., et al. „The preliminary performance study of the 3D printing of a tricalcium phosphate scaffold for...

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