System Solution: FlowPlate® Lab
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System Solution: FlowPlate® Lab Typical reactions : organometallic reactions (e.g. Grignard reaction, lithiation) Based on our experiences with a large number of different customer projects over many years we have come up with several reactor set-ups combining specific reactors from our portfolio with suitable pumps and other peripherals. These equipment combinations have already proven their usefulness in the field for certain types of reactions and are optimized for customer benefit. For organometallic reaction applications the challenges lie in very high reaction enthalpies, mass transport limitations and multi-step processes. Example: Organomagnesium based flash chemistry CH2ICl + iPrMgCl . LiCl in THF Operating conditions:  Throughput: Cl Reference: T. von Keutz, D. Cantillo, C. Kappe Organic Letters 2020 22 (19), 7537-41 DOI: 10.1021/acs.or

Our Process Development Team say: The FlowPlate reactor allows for fast scale-up. Ideal for pharma applications. Multi-step reactions are easy and flexible in this reactor. Classic low temperature reactions (-78 °C) can be handled at significantly higher temperatures. Safe process control allows expansion of process windows even above 0 °C. Extremely efficient mixing in phase-specific mixing structures. Technical Specifications Typical reactions Temperature range Pressure limit Reactor volume Volume flow Residence time Media-wetted materials organometallic reactions (e.g. Grignard reaction,...