PPD Capsule Filters Pleated Polypropylene Depth Media Applications Buffers and Other Media Diagnostics PPD capsules are made with polypropylene microfiber media. Designed with the optimal filtration area, the filters remove large amounts of particulate and other contaminants. PPD capsules protect critical membrane filters downstream by removing 99.9% of contaminants at the rated pore size. Specific applications for PPD capsule filters include pre-filtration of bulk pharmaceutical chemicals, water, buffers, solvents, alcohols and other liquids. PPD capsules also protect membrane filters in filling applications for SVPs, LVPs, diagnostics, ophthalmics, biologicals and other products. P rotect critical membrane filters downstream Wide range of high efficiency retention ratings H igh capacity for long life Polypropylene exhibits broad chemical compatibility, so it is particularly suited for the filtration of chemicals and solvents used in drug making processes. PPD capsule elements are integrity tested during manufacture and are flushed to assure cleanliness in critical process applications. Prefiltration of bulk chemicals, water, LVPs, SVPs, buffers, solvents PPD Capsule Filters - Filtration Area* Capsule Length Pleated Polypropylene Depth *Average – Filtration area varies with media thickness and porosity. Flow Rate / Filtration Area The following table represents typical water flow at a one psi (69 mbar) pressure differential across a single 2 inch capsule with 1.0 ft² (930 cm²) of media with 1/2” FNPT ports. The test fluid is water at ambient temperature. Higher pressure drops are acceptable, but as flows increase the pressure drop of the housing becomes more apparent. Pore Size * For approximate flow rates for 5” through 30” capsules, refer to the appropriate cartridge data sheet Construction Materials Maximum Operating Parameters Liquid Operational Pressure Filtration Media Pleated Polypropylene Depth Media Gases Operational Pressure Operating Temperature Media Support Forward Differential Pressure 50 psid (3.4 bard) at 20 °C (68 °F) Center Core Reverse Differential Pressure Outer Support Cage Sealing Method Thermal Bonding Recommended Changeout Pressure Pharmaceutical Grade Bulk Pharmaceutical Chemicals Biologicals

Integrity Test Information Each capsule assembly is integrity tested before release. Field duplication of these tests is not practical because of the absence of commercial portable testing equipment. The materials used to construct pharmaceutical grade PPD capsule filters are non-toxic and meet the requirements for the MEM Elution Cytotoxicity Test and the requirements for Biological Reactivity Tests in the current version of the United States Pharmacopeia (USP) for Class VI - 121 °C Plastics. In addition, the materials meet the requirements listed by the FDA as appropriate for use in articles...