PGD Capsule Filters Pleated Fiberglass Depth Media Applications LVPs and SVPs Buffers and Other Media PGD capsules are designed using composite media filter modules containing a fiberglass depth media and a final downstream layer of polypropylene depth media to ensure fiber free filtrate. They provide 99% retention at the rated pore size and have high contaminant holding capacity. These cartridges are used in prefilter applications as well as bioburden reduction. Each capsule filtration module is tested for integrity before shipment. Specific applications for PGD capsule filters include pre-filtration of bulk pharmaceutical chemicals, water, buffers, alcohols and other liquids. PGD capsules also are used for bioburden reduction in LVPs, SVPs, diagnostics, ophthalmics, and other final pharmaceutical products. Composite media filter rated at 99% retention at pore size High contaminant holding capacity with excellent retention W ide range of retention ratings Prefiltration and bioburden reduction in bulk chemicals, LVPs, SVPs, water, buffers PGD Capsule Filters - Filtration Area* Capsule Length Pleated Fiberglass Depth *Average – Filtration area varies with media thickness and porosity. Flow Rate / Filtration Area The following table represents typical water flow at a one psi (69 mbar) pressure differential across a single 2 inch capsule with 1.0 ft² (930 cm²) of media with 1/2” FNPT ports. The test fluid is water at ambient temperature. Higher pressure drops are acceptable, but as flows increase the pressure drop of the housing becomes more apparent. Pore Size * For approximate flow rates for 5” through 30” capsules, refer to the appropriate cartridge data sheet Construction Materials Maximum Operating Parameters Liquid Operational Pressure Filtration Media Pleated Fiberglass and Polypropylene Composite Depth Media Gases Operational Pressure Operating Temperature Media Support Forward Differential Pressure 50 psid (3.4 bard) at 20 °C (68 °F) Center Core Reverse Differential Pressure Outer Support Cage Sealing Method Thermal Bonding Recommended Changeout Pressure Pharmaceutical Grade Bulk Pharmaceutical Chemicals Diagnostics

Integrity Test Information Representative sample capsule elements are factory tested for integrity before shipment. Field duplication of these tests is not practical because of the absence of commercial portable testing equipment. The materials used to construct pharmaceutical grade PGD capsule filters are non-toxic and meet the requirements for the MEM Elution Cytotoxicity Test and the requirements for Biological Reactivity Tests in the current version of the United States Pharmacopeia (USP) for Class VI - 121 °C Plastics. In addition, the materials meet the requirements listed by the FDA as...