Pharma PES Capsules


Catalog excerpts

Pharma PES Capsules - 1

PPS Capsule Filters Double Layered Polyethersulfone Membrane PPS Capsules are hydrophilic and manufactured with the highest quality asymmetric polyethersulfone membrane, double layered for extra security. Polyethersulfone (PES) membrane exhibits excellent flow rates with high throughput. PPS capsules are used for sterilizing filtration, the most critical applications in the pharmaceutical industry. PPS capsule elements are 100% integrity tested during production. Validated for use in multiple pharmaceutical applications Excellent flow rates with high throughput Integrity testable Designed for minimal leachables and extractables Low adsorption of proteins and preservatives Flow Rate / Filtration Area The following table represents typical water flow at a one psi (69 mbar) pressure differential across a single 2 inch capsule with 1.0 ft² (930 cm²) of media with 1/2” FNPT ports. The test fluid is water at ambient temperature. Higher pressure drops are acceptable, but as flows increase the pressure drop of the housing becomes more apparent. Pore Size * For approximate flow rates for 5” through 30” capsules, refer to the appropriate cartridge data sheet Construction Materials Housing Filtration Media Double Layered Polyethersulfone (PES) Membrane Media Support Center Core Outer Support Cage Sealing Method Thermal Bonding Specific applications for PPS capsule filters are final, sterilizing filtration of USP Water for Injection (WFI), diagnostic solutions, vaccines, ophthalmics, SVPs, LVPs and biological products. Polyethersulfone is particularly suited for the filtration of products that contain elements that can adsorb to the media, such as preservatives and proteins. The lower binding characteristics of polyethersulfone (PES) make it a good choice for filtration of valuable protein solutions such as vaccines and biologicals as well as ophthalmic solutions. PPS Capsule Filters - Filtration Area Media PES Membrane Maximum Operating Parameters Liquid Operational Pressure Gases Operational Pressure Operating Temperature Forward Differential Pressure 50 psid (3.4 bard) at 20 °C (68 °F) Reverse Differential Pressure Recommended Changeout Pressure Pharmaceutical Grade

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Pharma PES Capsules - 2

Integrity Test Specifications - Diffusion Pore Size 0.03 μm 0.10 μm 0.22 μm 0.45 μm 0.65 μm 0.8 μm 1.0 μm 1.2 μm Integrity Test Specifications - Bubble Point Bubble Point (water wetted membrane) 0.03 μm ** 0.10 μm ** 0.22 μm 50 psig (3.5 barg) 0.45 μm 25 psig (1.7 barg) 0.65 μm 19 psig (1.3 barg) 0.8 μm 15 psig (1.1 barg) 1.0 μm 10 psig (0.7 barg) 1.2 μm 9 psig (0.6 barg) ** Test pressure exceeds operational limits of capsule filters. Use the diffusion test method. Pore Size PPS cartridges are validated using test procedures that comply with the intent of both ASTM F 838-05 and HIMA...

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