BPS Cartridge Filters PES Membrane Applications Buffers and Feedstocks Outside Diameter Filtration Area Integrity Test Specifications 10-inch cartridge, water wetted membrane Pore Size 0.03 μm Biopharmaceutical grade PS filters are hydrophilic and manufactured with asymmetric polyethersulfone (PES) membrane. PES membrane exhibits excellent flow rates with high throughput. BPS cartridge filters are used for critical bioburden reduction applications in the biopharmaceutical industry. Specific applications for BPS filters are bacteria removal in buffers, USP Water for Injection (WFI), SVPs, LVPs and other biopharmaceutical products. The filter elements are 100% integrity tested during production. Polyethersulfone is particularly suited for the filtration of products that contain elements that adsorb to the media, such as preservatives and proteins. The lower binding characteristics of polyethersulfone make it a good choice for filtration of valuable protein solutions such as vaccines and biologicals. Construction Materials Filtration Media Media Support Center Core Outer Support Cage Sealing Method Thermal Bonding Buna, Viton® (or FKM), EP, Silicone, FEP Encapsulated Silicone, FEP Encapsulated Viton (or FKM) Air Diffusion Rate < 30 cc/min at 60 psig (4.1 barg) < 30 cc/min at 48 psig (3.3 barg) < 30 cc/min at 35 psig (2.4 barg) < 30 cc/min at 20 psig (1.4 barg) < 30 cc/min at 15 psig (1.0 barg) < 30 cc/min at 12 psig (0.8 barg) < 30 cc/min at 8 psig (552 mbarg) < 30 cc/min at 7 psig (483 mbarg) Maximum Operating Parameters Differential Pressure • Forward Operating Temperature Recommended Changeout Pressure 82 °C (180 °F) at 10 psid (0.69 bard) in water 35 psid (2.4 bard) Sanitization/Sterilization Filtered Hot Water 90 °C (194 °F), 30 minutes, multiple cycles, max 3 psid forward flow In-line Steam For all elevated temperature procedures above, a stainless steel support ring is required. Chemical Sanitization Performed using industry standard concentrations of hydrogen peroxide, paracetic acid, sodium hypochlorite, and other selected chemicals. Biopharmaceutical Grade

Total Performance Critical Process Filtration, Inc. is a vertically integrated manufacturer of filtration products to industries in which filtration is considered a critical part of the manufacturing process. We supply a complete line of products and services to help you cost effectively satisfy all your filtration requirements from a single source. The materials used to construct biopharmaceutical grade filters are non-toxic and meet the requirements for the MEM Elution Cytotoxicity Test and the requirements for Biological Reactivity Tests in the current version of the United States Pharmacopeia...