Biopharm High-Capacity PVDF Capsules


Catalog excerpts

Biopharm High-Capacity PVDF Capsules - 1

BPVWL Capsule Filters High Capacity PVDF Membrane Applications Buffers and Feedstocks Plasma Products Applications for BPVWL capsule filters are bioburden reduction in buffers and media, water for injection (WFI), solvents, alcohols and other liquids. Our capsules provide high efficiency, validatable performance to protect downstream processes and sterilizing filters. Bioburden reduction in multiple biologicals applications Excellent flow rates with high throughput D esigned for minimal leachables and extractables PVDF is particularly suited for the filtration of products containing elements that can adsorb to the media, such as preservatives and proteins. The very low binding nature of PVDF makes it a good choice for filtration of valuable protein solutions as well as products that contain low amounts of preservatives. Low adsorption of proteins and preservatives BPVWL Capsule Filters - Filtration Area Capsule Length High Capacity PVDF Membrane Flow Rate / Filtration Area The following table represents typical water flow at a one psi (69 mbar) pressure differential across a single 2 inch capsule with 1.0 ft² (930 cm²) of media with 1/2” FNPT ports. The test fluid is water at ambient temperature. Higher pressure drops are acceptable, but as flows increase the pressure drop of the housing becomes more apparent. 0.22 μm Pore Size * For approximate flow rates for 5” through 30” capsules, refer to the appropriate cartridge data sheet Construction Materials Maximum Operating Parameters Liquid Operational Pressure Filtration Media High Capacity Polyvinylidene fluoride (PVDF) Membrane Gases Operational Pressure Operating Temperature Media Support Forward Differential Pressure 50 psid (3.4 bard) at 20 °C (68 °F) Center Core Reverse Differential Pressure Outer Support Cage Sealing Method Thermal Bonding Recommended Changeout Pressure Biopharmaceutical Grade BPVWL capsules are made using high capacity hydrophilic polyvinylidene fluoride (PVDF) membrane. The proprietary membrane casting process creates a thick membrane with a high capacity to hold contaminants, excellent retention characteristics, high flow rates and low protein binding. BPVWL capsules are used for critical applications in the processing of a wide range of liquids in biopharmaceutical production.

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Biopharm High-Capacity PVDF Capsules - 2

Biopharmaceutical grade filters typically exhibit low levels of non-volatile residues. The materials used to construct BPVWL capsule filters are non-toxic and meet the requirements for the MEM Elution Cytotoxicity Test and the requirements for Biological Reactivity Tests in the current version of the United States Pharmacopeia (USP) for Class VI - 121 °C Plastics. In addition, the materials meet the requirements listed by the FDA as appropriate for use in articles intended for repeated food contact as specified in Title 21 CFR sections 174.5, 177.1500, 177.1520, 177.1630, 177.2440, and...

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