BBC Cartridge Filters Blended Cellulose Membrane Applications Pre-filtration to increase the life of expensive final filters Final filtration — reduce bacteria counts and particle levels Typical Fluid Streams: Reagents/Standards Animal Serums Human Serums/Albumin Culture Media Fermentation Products Dimensions Length BBC filters are used for prefiltration and clarification applications in biopharmaceutical processing. Applications include bacteria and particulate removal in cell culture media, plasma products, serum, SVPs, LVPs and other biological products. The filter elements are 100% integrity tested during production. Blended cellulose membranes are particularly suited for the filtration of products that contain elements that can adsorb to the media, such as preservatives and proteins. The lower binding characteristics of the membranes make them a good choice for filtration of valuable protein solutions such as MAb solutions, serum and other biologicals. Construction Materials Filtration Media Blended Cellulose Membrane Media Support Center Core Outer Support Cage Sealing Method Thermal Bonding Buna, Viton® (or FKM), EP, Silicone, FEP Encapsulated Silicone, FEP Encapsulated Viton (or FKM) Filtration Area BBC cartridge filters are hydrophilic and manufactured with blended cellulose membrane. The process creates a thick membrane with very high loading capacity and high flow rates. The blended cellulose material is very low protein binding and allows protein rich solutions to pass with little impact on protein content. Outside Diameter Maximum Operating Parameters Differential Pressure • Forward Operating Temperature Recommended Changeout Pressure 82 °C (180 °F) at 10 psid (0.69 bard) in water 35 psid (2.4 bard) Sanitization/Sterilization Filtered Hot Water 90 °C (194 °F), 30 minutes, multiple cycles, max 3 psid forward flow In-line Steam For all elevated temperature procedures above, a stainless steel support ring is required. Chemical Sanitization Performed using industry standard concentrations of hydrogen peroxide, paracetic acid, and other selected chemicals. Total Performance Critical Process Filtration, Inc. is a vertically integrated manufacturer of filtration products to industries in which filtration is considered a critical part of the manufacturing process. We supply a complete line of products and services to help you cost effectively satisfy all your filtration requirements from a single source. Biopharmaceutical Grade

The materials used to construct biopharmaceutical grade filters are non-toxic and meet the requirements for the MEM Elution Cytotoxicity Test and the requirements for Biological Reactivity Tests in the current version of the United States Pharmacopeia (USP) for Class VI - 121 °C Plastics. In addition, the materials meet the requirements listed by the FDA as appropriate for use in articles intended for repeated food contact as specified in Title 21 CFR sections 174.5, 177.1500, 177.1520, 177.1630, 177.2440, and 177.2600 as appropriate. BBC filters comply with Title 21 CFR sections 210.3 (b)(6)...