BioPharmaceutical connections media/buffer preparation Bag systems incorporating MPC/MPX connections have a proven track record for use in media and buffer preparation for storage volumes of 1 to 2,500L. MPU connections are well suited for high volume applications. The HFC39 Series with integrated shutoff valves enables disconnection of single-use filters for post filtration integrity testing. Filtration/purification Following fermentation a number of filtration and purification steps are performed with each step requiring one or more connections. Buffer additions are easily made with MPC/MPX connectors in combination with SaniQuik™ adaptors. Applications such as product transfer or closed-loop TFF systems benefit from the contamination control advantages provided by Steam-Thru® Connections. fermentation Bioreactor seed trains are evolving as single-use technologies are merging with or replacing traditional stainless vessels and fixed piping thus increasing process flexibility and reducing turnaround time. Single-use bags and transfer lines utilizing MPC or MPX connections in conjunction with SaniQuik™ adaptors allow quick changeover. Utilizing Steam-Thru® Connections allows operators to make a sterile connection between pre-sterilized single-use systems and fermentation equipment for aseptic media transfer. FILLing Integrating single-use systems into filling operations reduces set-up time and operational costs. Single-use transfer lines replace three-way valve assemblies on stainless vessels by incorporating Steam-Thru® Connections. A throughthe-wall fluid transfer system allows operators to bring a portion of the transfer line into a suite where filling occurs; a quick-connect or Steam-Thru Connection enables attachment of the transfer line to the filling machine.

BioPharmaceutical connections Colder Products Company Colder Products Company is a leader in design and manufacture of couplings and connectors for life sciences markets. Colder’s connections ease biopharmaceutical manufacturers’ transition between stainless processing equipment and single-use systems; whether in an upstream fermentation process or a downstream application in formulation or final fill. These innovative solutions help biopharmaceutical manufacturers improve production yields, decrease time-to-market and reduce costs. Single-use systems minimize cross-contamination risks associated...