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CPC - Colder Products Company
Bio connection solution

Bio connection solution

Product catalog summary

Overview: Colder Products Company specializes in single-use connection technology for biopharmaceutical processes, focusing on reliability and sterility. Their solutions include sterile connect and disconnect options, designed to maintain product integrity while offering flexibility in component integration.

Product Specifications:

MPC and MPX: Easy-to-use connections for critical fluid applications, made from polycarbonate and polysulfone, with tubing sizes ranging from 1/8" to 1/2".
Sanitary Series: Connects directly to sanitary terminations, offering flexibility for single-use or hybrid systems, made from polysulfone.
Steam-thru® Connections: Allows sterile connections via SIP, made from polysulfone, with termination sizes from 3/8" to 3/4" sanitary.
AseptiQuik® DC: Offers both sterile connect and disconnect, made from polycarbonate, with termination sizes from 1/4" to 1/2" hose barb.
HFC39 Series: Features sterile disconnect functionality with automatic shutoff valves, made from polysulfone, with termination sizes from 1/4" to 1/2" hose barb.

Key Features and Benefits:

CLICK-PULL-TWIST Design: An intuitive connection process that reduces operator error.
Robust Construction: Ensures reliable performance without additional hardware.
Automatic Shutoff Valves: Prevents external contamination and eliminates the need for pinch clamps.
Market Availability: Open access through multiple supply chain partners.

Assembly Procedures:

AseptiQuik® Connectors: Utilize a "CLICK-PULL-TWIST" method for secure connections, with audible confirmation of assembly steps.
HFC39 Series: Features a simple one-step disconnection process that maintains sterility.

Materials and Sterilization:

Components are made from USP Class VI materials, including polycarbonate, polysulfone, and silicone.
Sterilization options include gamma irradiation and autoclave methods.

Conclusion: Colder Products Company provides a comprehensive range of connection solutions for biopharmaceutical processes, ensuring sterile and reliable connections with innovative designs and robust materials.

Stainless Steel Equipment and Single-Use Systems: The document also covers stainless steel biopharmaceutical processing equipment and single-use bag and tube systems, focusing on AseptiQuik StC Connectors. These connectors facilitate a Steam-in-Place (SiP) process, allowing sterile connections between stainless processing equipment and disposable systems.

Features and Benefits:

Three-Port Design: Enables a true steam-through SiP process, eliminating 'dead legs' and the need for laminar flow hoods.
Patented Valve Design: Allows sterile connection and disconnection with high media flow rates.
Thumb Latch/Tear-Away Sleeve: Secures valve position and provides a visual indicator of the process stage.
Material Compliance: BSE/TSE free materials meet ADCF requirements.

Specifications:

Pressure: Up to 35 psi in steam position and up to 20 psi in flow position.
Temperature: Steam position supports up to 275°F for 60 minutes; flow position ranges from 39°F to 104°F.
Materials: Polysulfone and silicone components, all USP Class VI and ADCF compliant.
Sterilization: Supports gamma irradiation up to 50 kGy and autoclave conditions.

Steam-Thru II Configurations: Offers flexibility with 'steam on' and 'steam off' functionality, minimizing cross-contamination risks. The design allows for a second SiP cycle after media transfer.

Applications: Suitable for fermentation, media/buffer preparation, filtration/purification, and fill/finish applications. Can be integrated into bag systems or transfer lines.

AseptiQuik STC Connectors: Combines AseptiQuik sterile connectors with Steam-Thru II SIP connectors, enhancing flexibility for hybrid processing. Features include intuitive aseptic connection steps and robust construction for reliable performance.

FAQs: Addresses common questions about the use and mounting of Steam-Thru and Steam-Thru II connectors, emphasizing their versatility and application in various processes.

Additional Specifications:

Pressure range: Vacuum to 60 psi (4.1 bar).
Temperature range: Polycarbonate: -40°F to 250°F (-40°C to 121°C); Polysulfone: -40°F to 300°F (-40°C to 149°C).
Main materials: Polycarbonate and Polysulfone, both USP Class VI, ADCF. O-rings are made of silicone, platinum-cured, USP Class VI, ADCF.
Sterilization: Gamma irradiation up to 50 kGy; Autoclave for Polycarbonate up to 250°F (121°C) for 30 minutes, up to 10 repetitions; Polysulfone up to 270°F (132°C) for 60 minutes, up to 25 repetitions. Sterilize uncoupled only.
Tubing Sizes: 1/8" to 1/2" ID (3.2mm to 12.7mm).

Procedures and Recommendations:

Ensure tubing meets stated inside and outside diameters.
Test the suitability of Colder’s products in specific application conditions due to potential effects of pressure, temperature, chemicals, and operating environment on performance.
Use ergonomic thumb latches for easy operation, even with gloved hands.
Utilize parting line-free hose barbs to eliminate potential leak paths.

Product Features:

MPC and MPX Series couplings offer ease of use and security for fluid handling applications.
Optional locking sleeves are available to prevent accidental disconnects.
Coupling halves can rotate when connected to reduce tube kinks.
Compatible with MPC and MPX Series inserts for easy conversion and transition between tubing sizes.

Sanitary Series:

Sanitary couplings attach directly to 3/4", 1", and 1-1/2" sanitary terminations.
Compatible with both stainless steel and plastic clamps.
Integral coupling adaptor allows easy conversion of sanitary terminations on filter cartridges or equipment.

Warnings:

Customer responsibility to test product suitability in their application conditions.
Actual performance may vary based on specific coupling configurations.

Specifications for 3/4" Hose Barb:

Pressure range: Vacuum to 35 psi (2.4 bar).
Temperature range: -40°F to 300°F (-40°C to 149°C).
Main materials: Polysulfone (amber tint), USP Class VI, ADCF.
O-rings: Silicone (clear), platinum-cured, USP Class VI, ADCF.
Sterilization methods: Gamma irradiation up to 50 kGy, autoclave up to 270°F (132°C) for 60 minutes, up to 25 repetitions.
Tubing size: 3/4" ID (19.1mm).

Product Features and Benefits:

3/4" hose barb facilitates rapid filling and emptying of bioprocessing bags.
Locking feature prevents accidental disconnects.
Sharp barb end minimizes fluid turbulence and dead space.
Shrouded, leak-free seal protects fluids and eliminates contamination risks.
Materials are BSE/TSE free and meet ADCF requirements.

Warranty and Liability: Colder Products Company provides a 12-month warranty against defects in workmanship and materials. The warranty is void if the product is misused or altered. The company does not warrant suitability for specific applications, and liability for indirect or consequential damages is excluded.

Company Overview: Colder Products Company specializes in single-use connection technology for life sciences markets, offering solutions like sterile connect and disconnect, SIP connections, and quick connects. The company is ISO 13485 certified, with products manufactured in an ISO Class 7 cleanroom. Founded in 1978, Colder operates globally with offices in nine countries.

Catalog excerpts

Colder Products Company Quick Couplings & Fittings for Plastic Tubing CONNECTION SOLUTIONS For applications where reliability and sterility are a must Connect with Colder.

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Colder Products Company, the leader in single-use connection technology, offers a wide variety of solutions including sterile connect and sterile disconnect. Our innovative designs offer flexibility to easily combine various components and systems while maintaining product integrity. For applications where reliability and sterility are a must, Connect with

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4 AseptiQuik®: Provides a quick and easy sterile connection, even in non-sterile environments. Material: Polycarbonate 7 AseptiQuik® DC: All-in-one single-use connection technology offering both a sterile connect and a sterile disconnect. Material: Polycarbonate 10 HFC39: Features sterile disconnect functionality with automatic shutoff valve, preventing external organisms from entering the media flow path upon disconnection. Material: Polysulfone 12 Steam-Thru®Connections: Allow quick and easy sterile connection via SIP between biopharmaceutical processing equipment and disposable bag and tube...

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aseptiquik connector Specifications Pressure: Up to 60 psi, 4.1 bar Temperature: Typical Flow Rate: C V = 14.4 max Gamma: Up to 50kGy irradiation Autoclave High Temp (HT) Version: Up to 266°F (130°C) for 30 minutes Termination Sizes: 3/8" (9.5mm) and 1/2" (12.7mm) ID hose barb, and 3/4" sanitary Main Components: Polycarbonate (white), USP Class VI, ADCF Lock Ring: Polycarbonate (blue), USP Class VI, ADCF ASEPTIQUIK CONNECTOR Pull Tabs: Polycarbonate (blue, standard version), USP Class VI, ADCF Polycarbonate (white, HT version), USP Class VI, ADCF Caps: Polypropylene (clear), USP Class VI, ADCF...

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Height/Diameter Total Length (with cap) Hose Barb Length Coupling Bodies with Blue Pull Tabs termination 3/8" Hose Barb 1/2" hose barb 3/4" sanitary Coupling Bodies - High Temperature with White Pull Tabs termination 3/8" Hose Barb 1/2" hose barb 3/4" sanitary Coupling Inserts with Blue Pull Tabs termination 3/8" Hose Barb 1/2" hose barb 3/4" sanitary Coupling Inserts - High Temperature with White Pull Tabs termination 3/8" Hose Barb 1/2" hose barb 3/4" sanitary | Call toll free 1-800-444-2474 or visit us at www.colder.com Copyright © 2012 by Colder Products Company. All rights reserved. Colder...

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Click–Pull–Twist Assembly Procedure 1 Align male and female couplings, push together until “Colder Click” confirmation. AseptiQuik CONNECTOR Slight rotation of the blue lock ring may be required for proper alignment prior to connection. 2 Snap membrane pull tabs together and pull from connector. 3 Twist the blue lock ring clockwise until audible “Colder Click.” Alignment of the lock ring rib with the body’s arrow indicator confirms final connection. Connect with Colder Sterile Fluid Transfer 6 | Call toll free 1-800-444-2474 or visit us at www.colder.com Copyright © 2012 by Colder Products Company....

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Specifications Pressure: Up to 60 psi, 4.1 bar Temperature: Gamma: Up to 50kGy irradiation Autoclave High Temp (HT) Version: Up to 266°F (130°C) for 30 minutes Termination Sizes: Main Components: Polycarbonate (white), USP Class VI, ADCF Lock Ring: Polycarbonate (blue), USP Class VI, ADCF Pull Tabs: Polycarbonate (blue, standard version), USP Class VI, ADCF Polycarbonate (white, HT version), USP Class VI, ADCF Caps: Polypropylene (clear), USP Class VI, ADCF Seals: Silicone (clear), platinum-cured, USP Class VI, ADCF AseptiQuik® DC Connectors are the first Springs: 316 stainless steel all-in-one...

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Product Dimensions Height/Diameter (with cap) Total Length (with cap) Hose Barb Length Coupling Bodies with Blue Pull Tabs termination 1/4" HOSE BARB 3/8" HOSE BARB 1/2" HOSE BARB Coupling Bodies - High Temperature with White Pull Tabs termination 1/4" HOSE BARB 3/8" HOSE BARB 1/2" HOSE BARB termination 1/4" HOSE BARB 3/8" HOSE BARB 1/2" HOSE BARB Coupling Inserts - High Temperature with White Pull Tabs termination 1/4" HOSE BARB 3/8" HOSE BARB 1/2" HOSE BARB | Call toll free 1-800-444-2474 or visit us at www.colder.com Copyright © 2012 by Colder Products Company. All rights reserved. Colder...

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Click–Pull–Twist Assembly Procedure 1 Align male and female couplings, push together until audible “Colder Click” confirmation. Slight rotation of blue lock ring may be required for proper alignment prior to connection. 2 Snap membrane pull tabs together and pull from connector. Twist the blue lock ring clockwise until audible “Colder Click.” Alignment of the lock ring rib with the body’s arrow indicator confirms final connection. When fluid transfer is finished, press the thumb latch down to complete the sterile disconnection. Both halves will remain sterile. The connector is now ready for sterile...

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Actual size Specifications Pressure: Vacuum to 125 psi, 8.6 bar Temperature: Main components: Polysulfone (amber tint), USP Class VI, ADCF O-rings: Silicone (clear), platinum-cured, USP Class VI, ADCF Springs: 316 stainless steel Gamma: Up to 50 kGy irradiation. Sterilize coupled or uncoupled. Autoclave: Up to 270°F (132°C) for 60 minutes. Up to 25 repetitions for uncoupled units and up to one repetition for coupled units. Termination Sizes: HFC39 Series sterile disconnect couplings prevent external organisms from entering into the media flow path upon disconnection. Automatic shutoff valves...

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Height/Diameter Total Length (including valve) Coupling Bodies termination In-Line Hose Barb Tubing size Metric Eq. 1/4" ID 6.4mm ID 3/8" ID 9.5mm ID 1/2" ID 12.5mm ID Coupling Inserts termination in-line hose barb Tubing size Metric Eq. 1/4" ID 6.4mm ID 3/8" ID 9.5mm ID 1/2" ID 12.5mm ID sealing cap MATERIAL A HFC32039 Polysulfone 1.44 (36.6) sealing plug o-ring MATERIAL A HFC30039M Silicone Seal Polysulfone 1.00 (25.4) USP Class VI All measurements are in inches (millimeters) unless otherwise noted. Tubing must meet stated inside and outside diameters. Couplings are pictured with valves unless...

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Bio connection solution

Bio connection solution

Catalog excerpts

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