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Corning® Gentest? Pre-coated PAMPA Plate System

Corning® Gentest? Pre-coated PAMPA Plate System
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Corning® Gentest? Pre-coated PAMPA Plate System - 1

Corning® Gentest™ Pre-coated PAMPA Plate System A 96 well permeable support system with a filter plate pre-coated with structured layers of phospholipids Features w Stable, pre-coated PAMPA plate is highly reproducible w Improved assay predictability over traditional PAMPA w Reduced mass retention of Drug compounds are screened for their oral absorption potential early in the drug discovery process in order to eliminate poor performers and to identify candidates that need to be modified. Parallel artificial membrane permeability assays (PAMPA) have become a very useful tool for predicting in vivo drug permeability and are well-suited as a ranking tool for the assessment of compounds with passive transport mechanisms. Use of the PAMPA assay allows for ranking of compounds into a low or high classification, using UV VIS spectroscopy or LC/MS. The Corning Gentest Pre-Coated PAMPA Plate System is a 96 well permeable support system with a filter plate that has been pre-coated with structured layers of phospholipids and a matched receiver microplate. The Corning Gentest Pre-coated PAMPA Plate System has been validated for use in PAMPA and comes ready to use in your assay.

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Corning® Gentest? Pre-coated PAMPA Plate System - 2

Product Performance Traditional PAMPA Membrane Studies of commercially available compounds demonstrated excellent correlation between permeability and human absorption. Highly absorbed compounds (i.e., antipyrine, caffeine, naproxen, ketoprofen), typically under-predicted by traditional PAMPA, demonstrated high permeability (better prediction) with the Corning® Gentest™ PAMPA Plate System. Improved Correlation with Caco-2 Data Traditional PAMPA Membrane 350 Under-predicted Compounds Under-predicted Compounds High Permeability High Permeability Comparison of the performance of traditional...

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