SPEED AND CONVENIENCE TO SIMPLIFY YOUR SAMPLE PREP WORKFLOW Captiva non-drip (ND) and ND Lipids now available in single cartridges Agilent Captiva ND and ND Lipids filter plates and cartridges provide a time-saving, cost-effective solution for your lab ur The ever-increasing sensitivity of today’s MS instruments allows labs to take k advantage of the speed and productivity of rapid protein precipitation and/or lipid removal. Agilent Captiva ND and ND Lipids filter plates and new 3 mL cartridges are designed to simplify your workflow and make particulate removal, protein precipitation, and lipid removal more user-friendly. The unique non-drip design simplifies your workflow with in-well precipitation, ends the need to use messy tip or well seals, and reduces the number of liquid transfer steps needed to process samples. You decide when it is convenient to apply vacuum; until then, the non-drip filter prevents flow. The lipid-removing feature of Captiva ND Lipids is specifically designed for LC/MS analysis, efficiently removing ion-suppressing phospholipids. Best of all, their dual-depth filter construction delivers a fast reproducible flow, so you get uniform sample treatment and reliable filtrate recovery in a fraction of the time of other protein precipitation plates. Captiva’s Dual-depth Filter (layers enlarged above): The two filter layers have different porosities, capturing large particulates first, then the small particulates. There is no clogging due to the non-linear path that the particulates must follow. Agilent Captiva ND and ND Lipids filter plates and 3 mL cartridges for sample filtration provide: • Easy automation: 96-well plates resist organic solvent flow until vacuum is applied • Exceptional flow: dual-depth filter avoids plugged membranes and lost samples • Efficient and fast protein and lipid removal: MS suitable samples in as little as one-fifth the time • Extends column lifetime/reduces instrument downtime: minimizes column and system backpressure issues, saving time and money on chromatography system maintenance • The right format for your needs: 96-well formats for automation and throughput, and 3 mL cartridges wi

Consistent performance for your sensitive analyses Get fast, reproducible flow with Agilent Captiva ND Reduce ion suppression with Captiva ND Lipids plates Post-Column Infusion (PCI) of Albuterol before treatment with Captiva ND Lipids plates Flow Rate Consistency (100 µL Plasma w/400 µL ACN) 300 Captiva ND Competitor 1 Competitor 2 Well Address 0 Agilent Captiva ND plates process samples quickly and uniformly without the need for positive pressure manifolds. Plus, its uniform flow facilitates vacuum processing making it more automation friendly. Note that the ion-suppression features (top trace)...

Confidently remove proteins and ion-suppressing lipids Lipid removal, determined by LC/MS/MS, demonstrates Captiva’s efficiency 1 Obtain outstanding protein removal (Captiva ND 96-well plate study) Control: Offline protein precipitation, 100 µL plasma Determination of Protein by Bradford Assay Counts (%) vs. Acquisition Time (min) Captiva ND Lipids plate, 100 µL plasma Residual phospholipids *none detected Average protein content post precipitation of a 100 µL human plasma sample (n=24, 4:1 ACN Precipitation) among plate manufacturers and techniques. Counts (%) vs. Acquisition Time (min) Try these...

Captiva ND Filter Plates Captiva ND Filter Cartridges (NEW) Description Unit Pore Size (pm) Filter Material Volume (mL) Unit Part No. Captiva ND 96-well Filter Plates Captiva ND plate, 0.2 pm, polypropylene Recommended for both methanol and 5/pk Captiva ND plate, 0.45 pm, polypropylene Suitable for acetonitrile only Captiva ND Lipids 96-well Filter Plates Captiva ND Lipids 96-well filtration starter kit Includes: 1 CaptiVac vacuum collar, 2 Captiva ND Lipids filter plates, 2 Captiva 96 deep-well 1 mL collection plates, and 2 Captiva collection plate pierceable covers Captiva ND Lipids 96-well...