Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma
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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 1

Engineering - Manufacturing - Installation Process equipment for production scale in chemistry and pharma Planung - Herstellung - Installation Anlagenbau fur die Produktion in Chemie und Pharma • Compact, customized solutions Kompakte Losungen nach Mass • Complete process units Komplettanlagen • Robust material and design Robustes Material und Auslegung • Reliable and safe operation Zuverlassig und sicher im Betrieb Applications / Anwendungen • Reaction Reaktion • Evaporation Verdampfer • Vacuum distillation / reflux Vakuum Destination / Reflux • Azeotropic distillation Azeotrope Destination • Rectification Rektifikation • Absorption Absorption [Mistier Pilot Plant and Reactor Systems

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 2

Büchi AG – Process equipment with tradition Büchi AG is a globally leading manufacturer of process equipment for the chemical and pharmaceutical industry. Company history: • 1946: founded by the brothers Jakob and Hermann Büchi Sr. in Uster, Switzerland • 1949: development of flexible glass connection system, break-through as plant manufacturer for chemical production in Switzerland • 1979: development of chemReactors for upscaling and small scale production in pilot plants and kilolabs • 1980: development of pressure reactor systems in glass and metal for laboratory and pilot plants • 981:...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 3

Büchi AG – Anlagenbau mit Tradition Büchi AG ist ein weltweit führender Hersteller verfahrenstechnischer Anlagen für Chemie und Pharma. Die Firmengeschichte: • 1946: Gründung durch die Gebrüder Jakob und Hermann Büchi sen. in Uster, Schweiz • 1949: Entwicklung flexibles Glasrohrverbindungssystem Durchbruch als Hersteller verfahrenstechnischer Anlagen für die chemische Produktion • 1979: Aufbau Technikumsanlagen für Pilotierung und Kleinmengenproduktion • 1980: Aufbau Druckreaktoren in Glas und Metall für Labor und Pilot • 1981: Aufbau Exportgeschäft Planung – effizient, massgeschneidert,...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 4

Components Bauteile Heat exchangers – Spiral condensers – Shell and tube condensers Depending on the plant size and the type of process as well as a result of the required heat exchange area, different types of condensers are used: • spiral condensers for production reactors up to 630 liters feature efficient cleaning • hell and tube condensers with heat exchange areas of up to 23m2 s are used for large reactors – they are available with inner tubes in borosilicate glass, silicon carbide (SiC) or Hastelloy and with optional safety chamber. Glass-spiral condensers in parallel configuration...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 5

SiC shell and tube type heat exchangers Silicon carbide (SiC) shell and tube type heat exchangers in sizes up to 23m2 feature outstanding heat transfer, which results in very compact process plant constructions and reduces operation costs. SiC Rohrbündelwärmetauscher Siliziumkarbid (SiC) Rohrbündelwärmetauscher in Grössen bis 23m2 zeichnen sich durch hervorragende Wärmeleitfähigkeit aus. Dies ermöglicht eine sehr kompakte Bauweise der Anlagen und reduziert die Betriebskosten. SiC inner tubes • outstanding thermal conductivity • excellent corrosion and abrasion resistance • superior thermal...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 6

Design – Calculation – Engineering Because of often encountered space restrictions and challenging processes a thorough layout plan, including design calculations of the apparatus, is required within the scope of the overall project design. The plant has to be optimally intergrated. Functionality, operator and maintenance access, and other factors must be taken into consideration. Project planning Our competent project engineers as well as sophisticated planning tools help to design the plants according to customer requirements in a timely fashion. Engineering Konstruktion Calculations...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 7

Aufgrund oft eingeschrankter Platzverhaltnisse undanspruchsvoller Prozesse ist die detailierte Planung, Berechnung zur Auslegung derApparate sowie eine ganzheitliche Planung des Projektes wichtig. Die Anlagen mussen optimal in den Raum eingepasst werden. Funktionalitat, Zugang fur Bedienung und Unterhalt usw. mussen beriicksichtigt werden. Projektierung Unsere kompetenten Projektleiter sowie die professionellen Planungstools helfen die Anlagen genau nach Kundenwunsch und termingerecht zu installieren. Berechnung Spezielle Softwaretools von Buchi ermoglichen die Berechnung...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 8

Processes Reaction, stirring, mixing Glass lined reactors (DIN-reactors AE or BE) are suitable for a variety of processes such as chemical reactions (atmospheric or under pressure), gas dispersion, mixing of liquids/solids, crystallization and heating/cooling. Extractions and phase separations can also be performed with the proper fittings on the bottom discharge valve. Büchi supplies complete systems with glass lined reactors from various suppliers. Fittings and instrumentation on the reactor are also included as well as distributors and collectors. Distillation A stirred reactor commonly...

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 9

Prozesse Reaktion, Rühren, Mischen Emaillierte Rührkessel oder Rührbehälter (DIN-Reaktoren AE oder BE) dienen verschiedenen Prozessen wie chemischen Reaktionen (auch unter Druck), Gaseinleitungen, Mischen von Flüssigkeiten/Feststoffen, Kristallisationen, Heizen/Kühlen, usw. Extraktionen/Phasenabscheidungen können mit den dazu notwendigen Armaturen auch am Bodenauslaufventil durchgeführt werden. Büchi liefert Komplettsysteme unter Verwendung von emaillierten Rührbehältern verschiedener Hersteller. Dies beinhaltet auch Armaturen und Messtechnik auf dem Reaktor sowie Verteiler und Sammler....

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Engineering – Manufacturing – Installation Process equipment for production scale in chemistry and pharma - 10

cGMP facility with 800 liter glass lined AE / BE reactors, distillation glass overhead with SiC condensers and glass lined receiver tanks for API production cGMP Anlage mit 800 Liter AE / BE Stahl-Emaille Reaktoren, Destillations-Glasaufbau mit SiC Kondensatoren und emaillierten Vorlagegefässen für API Produktion 4000 liter BE reactor with coated glass upper section 4000 Liter BE Reaktor mit beschichtetem Glasaufbau DN300 vapor line with protective glass coating DN300 Brüdenleitung mit Schutzbeschichtung

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