Affinity & Avidity transmembrane proteins: checkpoint molecules, GPCRs, cytokine receptors, ... chips feature flow-permeable, bio-compatible polymer cages, which physically retain any type of cells. Trap sizes are tailored to capture single cells. for the automated analysis of kon and koff binding rates on cells 01 UNLOADING of cell to waste

Avidity effects Biphasic dissociations reveal complex binding modes Fluorescence (kcps) Biphasic dissociation kinetics indicate two distinct binding modes: 1. Weak binding / affinity 2. Strong binding / avidity 0.5 nM Nivolumab 5.0 nM Nivolumab Dissociation The in vivo efficacy of checkpoint inhibitors is rationalized by scIC-derived binding kinetics: Stable binding of Nivolumab to PD-1 enables T-cell activation. Biologics development On-cell characterization of mono- and multispecific antibodies and other biologics High affinity ≠ strong binder 3 different mAbs binding receptor of interest on...