Group: Bruker
Catalog excerpts
CxT)L>O Isotopic Fine Structure • Beyond the Molecular Realm: Unambiguous Elemental Formula Determination Molecular Identification Innovation with Integrity
Open the catalog to page 1Resolve Beyond the Molecular Realm R=50,000 R Resolve unique isotopologues 15 View Natures Signatures • Discover new chemical information by resolving unique isotopologues • Confirm fundamental nuclear signatures to reveal the ‘true molecular formula’, by routinely working at resolving powers (RP) above RP=500,000, having easy access to RP > 1,000,000 when needed • The exceptional capability of ParaCellTM technology enables you to work beyond the molecular realm* * oldin, I. A.; Nikolaev, E. N., Rapid Commun. Mass Spectrom., 2011, 25, 122-126. B Marshall, A.G.; Hendrickson, C.L.; Shi,...
Open the catalog to page 2Isotopic Fine Structure (IFS) The value of fundamental nuclear signatures • Isotopic Fine Structure (IFS) is the unique mass spectral signature arising from naturally occurring isotopes within the molecule being measured • Classically, the isotopic pattern was described using the isotopes of carbon (13C1, 13C2), or more generally A+1, A+2, (see figure on opposite page) • The A+1 IFS pattern consists of 15N, 33S, 13C and 2H isotopes, while IFS in the A+2 pattern has 18O and 34S isotopes. Combinations of these elements create unique patterns thanks to different mass defects of the isotopic...
Open the catalog to page 3>1 Million Resolving Power IFS unravels molecular formulae of unknown species • The strong A+2 isotope suggests Chlorine. • Sulfur-34 is hidden even at RP = 500,000, so we need the ability to access higher resolution to resolve peaks that are not of equal intensities. • At eXtreme Resolving powers, isotopologues yield true qualitative molecular information on our unknown
Open the catalog to page 4IFS Powered Quantitative Information Precisely count heteroatoms A+1 Isotopologues 15N 1 Unknown sample is Reactive Blue 4 (C23H14Cl2N 6O8S2) Eliminate Errors Using Heteroatom Mass Spectrometry • Requires >500,000 RP to do it routinely • Able to acquire full mass spectrum, not only a subset • Perfect for quantitation of neutron labelled (2H,15N) tags
Open the catalog to page 5Sulfur and S-omics IFS allows discovery of completely new Sulfur containing metabolites with health promoting properties The IFS approach enables the ability to rapidly identify sulfur containing metabolites and calculate single sum formulas for each, increasing both the speed and accuracy of the workflow. The incredible power of this workflow is that with extreme resolving power and sum formula determination, rapid screening for other heteroatom (N & O) containing metabolites is also possible. Highlight: In 2013, Prof. Kazuki Saito, of the RIKEN Plant Science Center (group photo below),...
Open the catalog to page 6An Invitation to Push the Frontiers of Scientific Discovery Imaging In situ label-free imaging for visualizing the biotransformation of a bioactive pholyphenol Kim, Fujimura, Hagihara, Sasaki, Yukihira, Nagao, Miura, Yamaguchi, Saito, Tanaka, Wariishi, Yamada and Tachibanad Scientific Reports, 3, 2805 (2014) IFS analysis allows for the visualization of spatially-resolved biotransformation based on simultaneous mapping of EGCG and its phase II metabolites. Complements conventional molecular imaging techniques, and can contribute to biological discovery. Pyruvate carboxylase is critical for...
Open the catalog to page 7Isotopic Fine Structure Bruker Daltonik GmbH Bremen · Germany Phone +49 (0)421-2205-0 Fax +49 (0)421-2205-103 ms.sales.bdal@bruker.com - www.bruker.com to change specifications without notice. © BDAL 09-2016, 1847374 For research use only. Not for use in diagnostic procedures. Bruker Daltonics is continually improving its products and reserves the right Breakthrough discoveries by accessing information from fundamental nuclear signatures
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