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Toxtyper

Toxtyper

Toxtyper

Product catalog summary
Introduction
The document introduces the Toxtyper, a laboratory instrument developed by Bruker Daltonics for toxicology research, particularly in forensic and drug testing applications. It emphasizes the instrument's simplicity, speed, and reliability in delivering high-confidence results.

Specifications and Features
The Toxtyper is based on a comprehensive spectral reference library that covers all relevant compound classes for drug and drug abuse screening. It utilizes LC-MSn technology, which is noted for its speed and sensitivity. Key features include high-confidence identifications, comprehensive coverage, robust and easy-to-use design, and the highest sensitivity in detecting drugs of abuse in biological matrices like urine, blood, serum, and plasma.

Procedures and Workflow
The workflow for toxicology research using the Toxtyper is simplified, allowing for drug detection studies to be completed from sample to result in 30 minutes. The process involves sample preparation (LLE, SPE, or precipitation), data acquisition by LC-MSn, and library search using full-scan MSn data. The instrument is designed to be user-friendly, enabling even non-expert users to generate qualified data easily.

Technology and Innovation
The Toxtyper incorporates SmartFrag™ technology, which ensures complete fragmentation of compounds regardless of concentration or sample matrix. This leads to reproducible and standardized library search results, making the data transferable and reproducible across different Toxtyper systems.

Applications and Use Cases
The Toxtyper is used for toxicological research and is particularly beneficial in forensic labs due to its ease of use and fast result generation. It is not cleared for diagnostic use by regulatory bodies like the FDA but is intended for research purposes.

Library and Updates
The Toxtyper's spectral reference library is continuously updated with contributions from customers and partners, allowing for quick adaptation to new drugs and patterns of drug misuse. Users can create custom library entries to keep their research applications up-to-date.

Conclusion
The Toxtyper offers a valuable solution for toxicology research, combining advanced technology with user-friendly features to facilitate high-quality data generation in forensic and clinical research settings.
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Catalog excerpts

Toxtyper-1

Toxtyper Simplicity, Speed and Confidence: First Time – Every Time! Innovation with Integrity

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Toxtyper-2

Redefining Toxicology Research for Forensic and Drug Testing Applications Toxtyper Workflow Bruker answers demanding questions in toxicology research with the fastest and most sensitive LC-MSn technology on the market. The Toxtyper is based on a high-quality comprehensive spectral reference library covering all relevant compound classes for drug- and drugs of abuse-screening. Identification by true MSn To minimize data evaluation time, the highest confidence in toxicology research results is a must. The Toxtyper identifies compounds based on retention time, MS, MS2 and MS3 information, delivering...

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Toxtyper-3

Simplified workflow for toxicology research Simplicity and condence Toxicology research for xenobiotics and drugs of abuse requires handling of various biological matrices. The Toxtyper offers a simplified workflow for diverse samples such as whole blood, serum, plasma or urine. Confident identification using comprehensive full-scan MSn library search (> 850 library entries) can be achieved in the low ng/mL range. Drug detection studies: From sample to result in 30 min. Sample Preparation LLE, SPE or Precipitation Sample Serum/Urine Identification Report Library search using full-scan MSn data...

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Toxtyper-4

Push-Button Solution Easy access to high-value data Currently, LC-MS/MS instruments, software and workflows require expert knowledge to generate qualified data. The Toxtyper is changing the paradigm to make high-value LC-MS/MS data accessible in clinical research and forensic applications. Its dedicated software package with a simplified user interface, allows even non-expert MS users to analyze any type of sample with 1. Click "Queue job" to start System Status LC/MS System Queue Job(s)., 1Qi j-t-je jobs for analysis J Toxtyper Analysis Report Submitter Andrea Schneider Sample Description Metriod...

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Toxtyper-5

One fragmentation ts all The Toxtyper includes unique, patented Bruker technology that overcomes tedious optimization and tuning of collision energies for different compounds at varying concentrations. Using SmartFrag™ leads to a complete fragmentation of every compound in your sample irrespective of concentration, complexity or sample matrix: First Time, Every Time! This makes our Toxtyper libraries and your results completely transferable and reproducible. Amitriptyline: MS2 results of 7 Toxtyper systems Methadone: MS3 results of 7 Toxtyper systems Library spectrum Reproducible spectra on multiple...

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Toxtyper-6

Open Toxicology Concept Keep your research application up-to-date Toxtyper provides a ready-to-use spectral reference library of more than 850 compounds that is constantly updated through contributions from our customers and collaboration partners. New drugs, such as synthetic 1. Reference spectra cannabinoids are constantly appearing on the market, making it necessary to adapt your method quickly. User-defined library entries can be created in a few mouse clicks allowing your laboratory to quickly respond to new patterns of illicit and licit drug misuse. 2. Add to library 4. Updated library:...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.