timsTOF™ Flexibility to Empower Your Ideas Innovation with Integrity

timsTOF™ Flexibility to Empower Your Ideas With timsTOF™, Bruker introduces the next generation of ion mobility mass spectrometry Unlock an additional dimension using the power of trapped ion mobility spectrometry (TIMS) mass spectrometry. This unique capability strengthens confidence in your structures through adding to the information derived from retention time, m/z, and MS/MS, enabling a leap forward in the characterization of molecules. The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented CCS reproducibility...

Resolution of 200 achieved by a unique design Providing consistently high ion mobility resolution, timsTOF unravels the complexity of samples and unlocks insights that remain hidden in standard mass spectrometry. With high resolution ion mobility separation, timsTOF adds an orthogonal dimension that increases peak capacity beyond the resolving power achieved by chromatography and time-of-flight. Whereas unresolved precursor ions can yield inconclusive structural assignment, timsTOF enables more confident and specific identification. Even isomeric and isobaric compounds become accessible. Dr....

Flexibility to view samples the way you want What is TIMS? In Trapped Ion Mobility Spectrometry (TIMS), ions are propelled through the TIMS tunnel by a gas flow. An electrical field controls each ion from moving beyond a position defined by the ion’s mobility, where the push it experiences from the gas flow matches the force of the electrical field. Ramping down the electrical field allows selectively releasing ions from the TIMS tunnel according to their mobility. TIMS tunnel: High resolution ion mobility separation capable of resolution >200 with parallel accumulation capability for up to a...

Temperature controlled TOF analyzer: 50,000 resolving power without compromise in sensitivity or acquisition speed. Temperature control gives stability between runs Quadrupole: New design for improved transmission. Collision cell: Optimized for efficient ion transfer. Figure 2. Configuration of the timsTOF ion path. Maximize insights Analyze samples in survey mode for an overview and investigate a resulting heatmap interactively. Then, select an imeX mode to magnify a specific mobility range. Focusing on a target set of peaks, you can perform an accurate analysis of collisional cross sections...

Confidence through unprecedented detail and clarity timsTOF boosts confidence and specificity of compound identification with an expanded set of orthogonal qualifiers that are measured with great accuracy. timsTOF increases the depth of your LC-MS/MS workflow by adding high resolution ion mobility separation. Keep your established chromatography settings and investigate data in the usual way, e.g. create a Base Peak Chromatogram (BPC) of a compound of interest. Clean fragmentation spectra that are easily correlated with their precursor ion support conclusive compound identification. Ultimately,...

Expand what you know about a compound With timsTOF, you can construct enhanced libraries of compounds, where each entry is characterized by ppm accurate mass, collisional cross section (CCS) with a precision of < 0.5%, and Bruker’s unique isotopic pattern fidelity (True Isotopic Pattern or TIP). Myristic acid TIMS CCS 158.2 Å2 Literature value1 158.2 Å2 Difference 0 % Stearic acid TIMS CCS 173.3 Å2 Literature value1 173.2 Å2 Difference 0.1 % Lignoceric acid TIMS CCS 196.4 Å2 Literature value1 196.3 Å2 Difference 0.2 % Intact proteins +19 Zhang et al. Journal of The American Society for Mass Spectrometry,...

timsTOF™ Flexibility to Empower Your Ideas For research use only. Not for use in diagnostic procedures. Bruker Daltonik GmbH Bremen · Germany Phone +49 (0)421-2205-0 Fax +49 (0)421-2205-103 [email protected] - www.bruker.com Scan the QR-Code for more Details to change specifications without notice. © BDAL 05-2017, 1852680 Bruker Daltonics is continually improving its products and reserves the right