Optimized FTMS Solutions for the Most Challenging Applications nnovation with Integrity

Dedicated to the Most Challenging Applications solariX, the next-generation line of hybrid Qq-FTMS systems, is the culmination of key technology enhancements that provide unique capabilities in mass spectral performance and versatility. The technological advances encompassed by solariX provide: Superior Sensitivity Unmatched Mass Accuracy and Broadband Resolution Widest range of structural tools, including Electron Transfer Dissociation (ETD) Expansive Mass Range Selective Ion Enrichment and Enhanced Dynamic Range Application Directed and Optimized Solution Packages Common applications for solariX...

Performance Beyond Compare At the core of the solariX is dramatically improved sensitivity and dynamic range. This allows researchers to identify and analyze a much wider range of molecules than ever before, and to delve deeper into complex mixtures and analyze lower abundance species. Base Peak Chromatogram for LC-MS and LC-MS/MS of protein mixture More power for greater complexity The broadband, ultra high resolving power (increased 8-fold) and superb mass accuracy of solariX is more powerful than previously possible with any other mass spectrometer. This extraordinary increase in the number...

New Horizons for Biomolecule Analysis Expanded capabilities for biomolecule analysis Myoglobin, non-denaturing MS conditions Resolving Power = 450,000 @ m/z 1953 Adding to the existing arsenal of structural fragmentation tools, solariX is fully enabled with Electron Transfer Dissociation (ETD). This exciting new technique is superb for in depth, comprehensive analysis of proteins and peptides and their subtle, posttranslational modifications. For instance, the gentle molecular dissociation chemistry associated with ETD enables researchers to elucidate subtle post-translational modifications such...

Definitive molecular identification With the solariX, high sensitivity, superior quality, exact mass measurements are only a mouse click away. Leveraging sub-ppm levels of mass accuracy for both intact precursor (MS) and product ions (MS/MS) combined with accurate isotope patterns, SmartFormula3D™ provides definitive elemental composition and molecular formula information. This level of confidence is readily achieved without internal standards or recalibration and the high resolution data inherently mitigates the complications resulting from other chemical interferences. Molecular formulae determination...

CASI™: For rapid, enhanced selectivity and dynamic range CASI Figure The unique Qq-FTMS geometry of the solariX can enrich lower abundant or trace species for detection and structural interrogation via MS and MS/ MS, respectively. This mode, known as Continuous Accumulation of Selected Ions (CASI), is essential for tissue imaging, analyzing low-copy PTMs, and to extend the general dynamic range of almost any measurement. This can improve signal intensities by as much as an order of magnitude. “Q” Schematic of CASI workflow where target ions are selected and enriched in the collision cell. Solution...

High-End Performance for any Analytical Laboratory CASI boosts sensitivity, enabling the detection of drug and metabolites at lower concentrations Full mass range MS Molecular imaging of olanzapine in kidneyDosage – 5 mg/kg, 6h post dosage analysis. The solariX FTMS is as intuitive and easy to use as a benchtop instrument. Bruker’s Compass™ software enables the researcher to harness the analytical power and versatility with ease so that the focus is on the application and not on the instrumentation. Weekly cryogen “fills” become annual… Bruker’s patented refrigerated magnet technology means nitrogen-free...

Unique Features of solariX Ultimate versatility in structural analysis The solariX leverages the complementary nature of traditional quadrupole based Collisional Induced Dissociation (CID), and now Electron Transfer Dissociation (ETD). Additionally, precursors of complex mixtures may be isolated and fragmented using high front-end resolution, in-cell isolation followed by Electron Capture Dissociation (ECD) or Sustained OffResonance Irradiation (SORI)-CID. Whether your application is natural product, peptide/protein, carbohydrate, orpetroleum product analysis, solariX has an array of fragmentation...

• Flexible Front-end Solutions The powerful Compass software enables the operation of a range of industry standard HPLC and u-HPLC platforms with the solariX. This includes comprehensive system control and seamless integration of mass spectral and UV data. Ik Acquisition / jingle inec. Polarity: Positive Chromatography Mode Mode Sw* 1(I(I> ETD transfsi CstttfitiSTi Sburti MS/MS AutoMS/MS O In-Cell r.isr, □ rsclation ECD Pulse Iength □ Pulsed Va Ive □ n/OfF ECD Bias solariXcontrol™ - the instrument control software for solariX

Technical Specifications Magnet 7.0T/US/R refrigerated magnet Field strength Analytical Performance Mass Range 100 – 10,000 m/z (transmission with RF only) 100 – 6,000 m/z (mass selective) MS/MS Operation Isolation efficiency (Qh-Interface) (LHRH, [M+2H]2+) MS/MS Efficiency (Qh-Interface) (LHRH, [M+2H]2+) > 50% conversion from isolated precursor Multistage MS (MS3 guaranteed) (LHRH) LHRH MS/MS (collision cell) -> MS/MS/MS (Infinity Cell™) Mass Dependent MS/MS Automated isolation and MS/MS of the most intense ions in an LC-MS/MS run (scan ratio set to five) S/N > 10:1 for 5 fmol (consumed). c5...