Bruker Daltonics ImagePrep Comprehensive and Reliable Tissue Sample Preparation for MALDI Imaging think forward MALDI-TOF MS

Fully-automated Matrix Preparation New technology: vibrational vaporization In the ImagePrep station, a matrix aerosol is created by vibrational vaporization under controlled conditions that is gently deposited onto tissue sections. An average droplet size of ~20 µm is generated, all droplet diameters are < 50 µm. 0,1 mm Reproducibility and quality control 2 mm Density of MALDI matrix layer as a function of the number of spray cycles (10 – 70 cycles). Center: Droplet Distribution of a single spray cycle. “Push-button” matrix application The ImagePrep is a Matrix Deposition Device for MALDI Imaging...

High resolution molecular images High Quality MALDI Imaging Data Intens. [a.u.] x10 4 1-38 1-40 1-37 1-39 5 1-42 4 3 2 1 0 3800 4000 4200 4400 4600 4800 m/z 1 mm Acquire high quality spectra Typically, tissue images are obtained that combine an unmatched high spectrum quality with many peptide/ protein signals and a high spatial resolution. A lateral resolution of 50 μm was observed in an Alzheimer rat model, identical to the spot raster used. This result suggests that even higher resolutions can be achieved. ImagePrep completes Bruker Daltonics MALDI Molecular Imager suite Intens. [a.u.] x10...

Technical Specifications Spray device for comprehensive and reliable tissue sample preparation for Imaging MALDI High spatial resolution 50µm and high spectra quality at the same time Patented sensor control enables active real-time process control and ultimate reproducibility Matrix aerosol generation with patented vibrational vaporization in a controlled atmosphere Low (ml) matrix consumption AutoPrep mode: Push-button operation and predefined methods for standard usecases Expert mode with full method develpment capabilities Compact size Easy-to-clean Teflon coated spray chamber TN-18: A New...