Unlocking insights in protein structure conformation Are you looking for a way to identify structural hotspots within your potential biotherapeutic? Or searching for a solution to understand structural conformational changes occurring during formulation or storage? Do you want to know more about protein-ligand (drug/protein) interactions? The Bruker HDX Solution tool kit delivers automated and reliable HDX-MS workflows with correct monoisotopic accurate-mass readout to fully explore quantitative results from H/D ratios. Combining the HDX Solution with the maXis II ETD UHR QTOF with its market-leading ETD fragmentation capabilities opens up a new era in HDX-MS studies, proving enhanced specificity at the residue level and the option to perform top-down HDX-MS studies. Researchers can access structural insights about their biomolecules reliably and with greater certainty and confidence. Innovation with Integrity

Fast, Reliable, Automated Structural Conformation Characterization The Bruker HDX Solution is a complete toolkit combining the LEAP HDx PAL, a UHPLC pump, the Bruker maXis II ETD and Sierra Analytics HDExaminer software. Robustness and Reliability Built-in High quality chromatographic and MS data The most advanced vendor independent HDX system, the LEAP HDx PAL automates the HDX experimental workflow, schedules and performs labelled experiments, followed by quenching and injection under cold conditions. Chromatographic separation under UHPLC conditions followed by mass spectrometric detection...