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Bruker Daltonics
Brochure micrOTOF II

Brochure micrOTOF II

Product catalog summary

Overview
The document provides a detailed description of the Bruker Daltonics micrOTOF II, a high-resolution time-of-flight mass spectrometer (TOF-MS) that offers flexibility and accuracy in mass spectrometry applications. It highlights the system's capabilities in formula generation, multi-target screening, and biomarker profiling.

Specifications
The micrOTOF II features a mass range of 50 – 20,000 m/z, a mass resolution of 16,500 FWHM, and a mass accuracy of less than 1-2 ppm with internal calibration. It supports both positive and negative ion polarity switching and offers various source options, including ESI, APCI, and APPI.

Procedures and Applications
The system is designed for a wide range of applications, including molecular formula verification, de novo formula generation, multi-target screening, biomarker discovery, and intact protein analysis. It supports coupling with both LC and GC systems, enhancing its versatility in analytical labs.

Key Features
- SmartFormula: Enhances formula generation by combining mass accuracy with True Isotopic Pattern (TIP) analysis.
- High Dynamic Range: Offers stability in mass measurement over a wide dynamic range, crucial for screening applications.
- Multi-Target Screening: Capable of screening hundreds of compounds in a single run with high specificity and reproducibility.

Software and Integration
The micrOTOF II is supported by the Compass software environment, which includes modules for molecular formula generation, data processing, and optional applications like TargetAnalysis and MetaboliteTools. It integrates seamlessly with various LC systems, including those from Agilent, Waters, and Dionex.

Conclusion
The Bruker Daltonics micrOTOF II is a sophisticated mass spectrometer offering unparalleled flexibility and accuracy for a wide range of analytical applications. Its advanced features and integration capabilities make it a valuable tool for research and development in various scientific fields.

Catalog excerpts

Bruker Daltonics The Powerful, Flexible Analysis Solution >

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Being fully furnished with convincing mass accuracy, a high dynamic range and speed of analysis, micrOTOFII is the first choice for: Molecular Formula Verification De novo Formula Generation Multi-Target Screening Biomarker Discovery Intact Protein Analysis > Highest flexibility Significance in biomarker profiling The micrOTOF II is the first high resolution TOF-MS which can be used in combination with GC and LC, providing unequalled flexibility with remarkable mass accuracy. Metabolic profiling is a key technology in the study of drug efficacy, toxicology or clinical biomarkers. Capabilities...

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# possible formulae Mass accuracy > plus Chemical expertise additional confidence > plus SmartFormula (mass accuracy + TIP) sub-ppm confidence > De novo sum formula generation Detection of C > 21 H > 24 ClFNO > 2 Haloperidol with SmartFormula: The correct formula has the best Sigma-ranking (isotope pattern matching factor). Top spectrum: Measured, lower spectrum: Calculated theoretical isotopic distribution. >

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mass accuracy over intensity mass accuracy over time mass accuracy over mass range ֢ɤ 2mDa are gene- rated in a single experiment for >200 compounds2. A stability of <1mDa is achieved over time of experiment ID of unknowns Retrospective in silico screening for new or unexpected compounds is possible because, unlike in triple-quad based MRM methods, the full scan information content in addition to the target library specific information is retained. Read more: Application Note ET-12. Intra-spectra dynamic range Quantitative and qualitative analysis for forensics, doping control, and residue analysisScreen...

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Worldleading combination of mass accuracy, resolution, and sensitivity SmartFormula is the unique combination of accurate mass with True Isotopic Pattern (TIP) Automated determination of elemental composition, the formula finderӔ Footprint 640 x 640 mm, height 1220 mm, weight 130 kg > Mass range 50 20,000 m/z Mass resolution 16,500 FWHM with micrOTOF focus Mass accuracy of < 1-2 ppm (RMS) error with internal calibration Mass Stability & Dynamic Range proven by better than 2mDa hrEICs (high resolution Extracted Ion Chromatograms) Sub-ppm confidence by application of SmartFormula algorithm Acquisition...

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Brochure micrOTOF II

Brochure micrOTOF II

Catalog excerpts

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