Overview: The Metabolic Profiler LC-MS is a comprehensive analytical solution designed for advanced metabolomics research. It integrates unique molecular formula generation capabilities, multivariate statistical tools, and library search options to provide sub-ppm confidence in compound identification.
System Configuration: The system supports various HPLC and fastLC models, and includes micrOTOF focus or micrOTOF-Q for mass spectrometry. It features a common user interface, Compass, for all Bruker Daltonics Life Science software, and includes ProfileAnalysis for multivariate statistics and DataAnalysis for post-processing of LC-MS data. Optional MetaboliteTools software is available for metabolite identification.
Advanced Features: The system offers unique structure elucidation capabilities with LC-MS/NMR integration. It can be expanded with Bruker BioSpin’s Avance NMR technology for enhanced metabolic profiling. The micrOTOF technology provides high mass accuracy, resolution, sensitivity, and isotopic fit.
Statistical Tools: ProfileAnalysis enables fast and comprehensive multivariate statistical analysis and interpretation of LC-MS data. Accurate mass and SigmaFit isotopic pattern analysis allow for intelligent compound identification with sub-ppm confidence.
Applications: Metabolic profiling is crucial in pharmaceutical research for studying drug efficacy and toxicology, and in clinical research for biomarker profiling. It is also used in food, chemical, and nutraceutical industries for research, process, and quality control. The system supports a wide range of sample matrices, including blood, urine, cerebrospinal fluid, tissue extracts, and food and beverages.
Research Use: The Metabolic Profiler LC-MS is intended for research use only and is not suitable for diagnostic procedures.
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