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amaZon speed

amaZon speed
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amaZon speed Ion Trap Performance Beyond Imagination Innovation with Integrity

amaZon – Turning Speed into Solutions The amaZon speed ion trap series sets new analytical standards for proteomics and small molecule applications. Design improvements to a well proven platform, offer dramatically enhanced speed, mass resolution, MS/MS efficiency and reproducible quantitation, delivering unsurpassed performance. Unmatched ion trap performance through innovation Greatly increased MS/MS duty cycle for more productive data acquisition Further improved resolution on a market-leading system with an unrivalled value of 30,000 in full scan Highest ion trap mass accuracy through...

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Accelerate your Success Flexibility for general chemistry Bottom-up proteomics identifying more Walk-up OpenAccess push-button low abundant proteins software Outstanding ETP/PTR applications for Fast MSn library search solutions full PTM analysis Most flexible API sources including the Top-down sequencing (TDS) for highest new CaptiveSpray™ for proteomics, protein sequence coverage APCI, and DIP for solid samples Speed for drug research Drug quantification by UHPLC driven LC-MS methods Metabolite identification and prediction by advanced software tools In vacuum RF detection Ion guide High...

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Translating Speed into Proteomic Information Bottom-up analysis with a maximum number of identified proteins Productivity, robustness and high sequence coverage by CaptiveSpray™ The complexity of the proteome still challenges analytical technologies. The high dynamic range and complexity due to posttranslational modifications require maximum speed and sensitivity to capture as many peptides as possible. The amaZon speed ion trap sets new standards in protein identification due to its enhanced MS/MS speed, new faster isolation and SMART fragmentation. This results in the identification of >...

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Get the Full Picture: PTM Discovery The regulatory function of many autoMS/MS proteins is controlled by reversible posttranslational modifications (PTMs) such as phosphorylation. In PTM analysis, Neutral loss both characterization and localization of the modification site are of major importance. detected? ETD is the method of choice for analyzing TGSESSQTGTSTTSSR biologically important PTMs. Phosphorylation site T1 or S3? In contrast to CID, ETD preserves modifications of the peptide backbone, No Yes enabling unambiguous assignment of the modification site. Market-proven ETD technology...

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Top-down Protein Characterization by ETD/PTR Unrivalled performance in Top-down MS/MS by ETD/PTR Top-down sequence elucidation of intact proteins requires highly efficient MS/MS. The powerful combination of ETD and PTR generates multiply charged fragments controlling the product ion charge state on demand. Using the amaZon speed in Maximum Resolution mode enables sequencing of proteins of > 16 kDa from both termini, as shown for intact myoglobin (sequence coverage of 98 % by a Mascot TDS database search). The unrivalled performance of the new Maximum Resolution mode is demonstrated by the...

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Quantification Built on Speed Enhancing productivity for Therapeutic Drug Monitoring (TDM) Reliable and routine quantification is a task so far reserved for triple quadrupole instruments. The enhanced speed and reproducibility of the amaZon speed in MRM experiments enables the reliable quantification of target compounds in diverse matrices. Shown here is the quantitation of four immunosuppressants in a multiplexed MRM assay. The requirements for this TDM assay were adopted directly from a clinic and transferred to the amaZon speed together with the respective calibrators, controls and...

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Structure Verification and Metabolite Identification MSn for structure analysis, supported by powerful data interpretation software The identification of drug metabolites and their structure verification are a vital part in pharma discovery and development. This is also true for synthesis control in organic chemistry in general. Software features including the FragmentExplorerTM are the ideal tools for HN structure confirmation taking advantage of the fast and sensitive stepwise MSn fragmentation of the amaZon speed ion trap. Bruker‘s MetaboliteToolsTM software suite provides confident...

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Walk-up solutions for a multi-user environment The Compass OpenAccess OA/QC software allows users with little to no training to generate valuable LC-MS/ MS data on the fly. This is a web-based client server system with push-button solutions i.e. for quality control (QC), recombinant protein MW verification and automatic library searches. The intuitive workflow-oriented GUI in combination with the flexibility and speed of the amaZon is an ideal solution for multi-user industrial, clinical or teaching labs. Automated check of a synthesis compound 80% purity detected. Automated check of a...

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Technical Specifications Technology driven solutions SmartFrag™ for reproducible MS/MS spectra generation and confident library searches Zero Delay Alternating™ polarity for up to 20 Hz MS acquisition speed supporting UHPLC applications Dual ion funnel for maximum sensitivity over a broad m/z range Patented SmartICC™ for optimal ion storage SMART isolation and SMART fragmentation Panorama fragmentation (PAN) enabling CID fragmentation without 1/3 cutoff MS/MS modes Data-dependent auto MSn Preferred mass lists for automated feedback experiments from MetaboliteTools and ProteinScape Scheduled...

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