NANOSTAR - Compact, High-performance SAXS Solutions for Structrural Biology
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NANOSTAR Compact, High-performance SAXS Solution for Structural Biology Innovation with Integrity

SAXS – Expanding the Frontiers of Structural Biology Biological small-angle X-ray scattering (BioSAXS) is becoming an essential technique in structural biology. For both simple and complex systems, SAXS is a great complimentary tool for elucidating the size, conformation, and flexibility of biological molecules in solution—under physiologically-relevant conditions. Additionally, since SAXS requires minimal sample preparation, it is possible to get valuable structural information faster than almost any other technique. A more recent development is the advance of powerful new software tools...

NANOSTAR features and benefits METALJET source and HELIOS-P optics for the brightest and highest-quality beam available in the home laboratory SCATEX scatterless pinholes for the highest flux and lowest parasitic scattering VÅNTEC-2000, the largest photon-counting detector available in the home laboratory, for the best signal-to-noise ratio SCÅTTER, the most powerful and easiest-to-use software package for macromolecular SAXS Best angular resolution for low Q min Very compact system Dual-port configurations with seamless integration with D8 VENTURE crystallography systems NANOSTAR –...

METALJET X-ray Source and Optics The brightest source available in the home lab No external cooling water or 3-phase power required, for easy siting and installation Fully integrated: all source configuration, autocalibration and adjustment is automated Unique, patented low-figure-error optics preserve all of the METALJET’s brightness Synchrotron-quality optics Parallel beam with three times the flux of conventional optics Divergence below 0.5 mrad SCATEX pinholes for reduced parasitic scatter and twice the flux Dual-port Solution The NANOSTAR can be configured as a stand-alone or dual-port...

Versatile Sample Chamber ■ Large sample chamber accommodates a variety of sample holders ■ Temperature-controlled liquid sample stage holds up to six sample ■ Excellent sample visibility with large, transparent, radiation-tight door ■ Automated sample loader for unattended analysis of up to 96 samples (optional) ■ Highest experimental flexibility thanks to flanges for additional supply ■ Optional flow cell ■ Largest active area available in the home ■ High-sensitivity, real-time photon counter ■ High dynamic range ■ Lowest noise of any detector, less than two noise counts per pixel per year...

METALJET with HELIOS MX The METALJET uses a liquid target consisting of a galliumrich alloy. Shorter-wavelength Ga-Ka radiation causes less radiation damage and facilitates highmultiplicity data sets The optimized HELIOS MX optics provides a beam optimized for the best signal-to-noise ratio Always fresh, self-healing target for high power load with long-term constant beam intensity Revolutionary Path Planning Revolutionary control software using advanced algorithms for optimized goniometer performance Software uses a 3-D model of the current hardware configuration for real-time path...

KAPPA Goniometer The KAPPA 4-circle goniometer’s open geometry offers ultimate sample positioning freedom, for unconstrained multiplicity of observations. The detector-to-sample distance is automatically optimized based on unit cell dimensions and crystal quality. Easy sample mounting and harvesting SNAP-LOCK mount for simple exchange Set of optimized collimators included PHOTON II Charge-Integrating Pixel Array Detector Largest monolithic active area: 140 cm2 Quantum-limited sensitivity High speed: up to 70 frames per second Zero readout dead time No nonlinearity at high count rates No...

List of selected publications Bothe J.R., Tonelli M., Ali I.K., Dai Z., Frederick R.O., Westler W.M., Markley J.L. (2015) The Complex Energy Landscape of the Protein IscU. Biophys J., 109, 1019-25. Tay, M. Y. F., Saw, W. G., Zhao, Y., Chan, W. K. K., Singh, D., Chong, Y., Forwood, J. K., Ooi, E. E., Grüber, G., Lescar, J., Luo, D., and Vasudevan, S. G. (2015) The C-terminal 50 amino acid residues of Dengue NS3 protein are important for NS3-NS5 interaction and viral replication. J. Biol. Chem., 290, 2379-2394. Nartey, W., Basak, S., Kamariah, N., Manimekalai, M.S.S., Robson, S., Wagner, G.,...