D8 Venture - D8 Quest - D8 Structural Biology Solutions
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D8 VENTURE D8 QUEST D8 Structural Biology Solutions Innovation with Integrity

Stable and easy-to-align beam path Low-temperature device options PHOTON II™CPAD detector Microfocus TXS™ source Wide doors for optimal access METALJET™, the most intense home source

X-ray Crystallography: Driving the Structural Biology Revolution The field of structural biology continues to advance dramatically with researchers tackling ever more complex and challenging macromolecular structures. X-ray crystallography is a crucial tool in this ongoing quest, accounting for over 93% of the structures deposited in the Protein Data Bank in 2015. The best in-house X-ray system can offer a significant advantage in this highly competitive field. With the latest source and detector technology, one need no longer wait for synchrotron-quality structures. Great research deserves...

Substrate binding Membrane proteins Protein-DNA complexes Molecular motors Long unit cell axes Molecular replacement GPCR crystallography Twinned crystals Structural enzymology 1) Kostan, J; Sjöblom, B; Maixner, F; Mlynek, G; Furtmüller, P G; Obinger, C; Wagner, M; Daims, H; Djinovic-Carugo K: J. Struct. Biol. 2010, 172, 331 2) Benning, M: Bruker application laboratory Madison, WI, USA 3) Beck, T; Krasauskas, A; Gruene, T; Sheldrick, G M: Acta Cryst. 2008, D64, 1179 4) Fedorov, R; Witte, G; Urbanke, C; Manstein, D J; Ute Curth, U: Nucleic Acids Res. 2006, 34, 6708 5) Sauve, V; Roversi, P;...

Optics Source Brighten Up your Home Lab: METALJET, TXS, and IµS 3.0— all with HELIOS MX Liquid metal METALJET with HELIOS MX optics High flux, stability, small beam size, and low divergence are essential for collecting the highest-quality data from challenging crystals. These requirements have driven developments in synchrotron design. Now, Bruker has applied these important lessons to home-lab source technology. Our sources now deliver beam intensities comparable to those of typical bendingmagnet beamlines. The modern METALJET now crosses the next boundary, matching diffraction limits...

Home Sources vs. Bending Magnet Beamlines 200.00 increased data collection efficiency, reduced X-ray absorption by the sample, and reduced scattering by both mother liquor and air. The METALJET’s ultra-intense Ga-Kα beam takes advantage of all these benefits. Your personal beamline. In the past, finding the right X-ray source for your lab demanded a choice between the highest performance and the lowest maintenance. Now you can have it all: Bruker’s new X-ray sources are designed to combine superb performance with unprecedented stability, maximum uptime, and easy maintenance. All of our compact...

Every photon diffracted from your sample provides a quantum of information that describes the protein’s unique structure. This is why the ideal detector must faithfully record each and every photon in order to preserve this precious information. The new PHOTON II detector comes very close to this ideal, with speed, sensitivity, and accuracy superior to that of any other detector. PHOTON II: The Future of Detection is Now Detective Collection Efficiency (DCE) for various detectors Detective Collection Efficiency (DCE) 0.270 Reflections: 10 X-rays Exposure time: 10 sec Radiation: Cu Kα, 8.1...

CPAD—Charge-Integrating Pixel Array Detectors: from the XFEL to your home laboratory. To overcome the shortcomings of HPADs, a new technology—the Charge-Integrating Pixel Array Detector (CPAD)—has recently been developed for use at fourth-generation X-ray Free Electron Laser (XFEL) sources. CPADs come much closer to an ideal detector than any other technology. The PHOTON II CPAD is the first detector to bring this groundbreaking new technology to the home laboratory. PHOTON II detector, air-cooled The PHOTON II CPAD features: The largest monolithic active area of any pixel array detector No...

Superior PHOTON II CPAD Charge-Integrating Pixel Array Detector 10.0 x 14.0 cm = 140.0 cm2 active area Large active area: see more from your sample, lose the gaps High Speed High Dynamic Range Best Data No charge sharing noise: eliminate the dead border area Incident spot X-ray signal, hitting the center of a pixel Detected X-rays X-ray signal, hitting the corner of a pixel Detected X-rays Detected X-rays The PHOTON II features the largest monolithic X-ray sensor available for superior coverage with absolutely no gaps. The PHOTON II has no charge sharing losses and thus no dead border...

Best Linearity Large Active Area Best Spatial Resolution Displayed image Image pixel PHOTON II holds All the Aces Image pixel The largest monolithic active area of any pixel array No gaps due to the use of a single wafer-scale silicon sensor No charge sharing noise Zero counting losses The pixel response from the detector to the displayed image is essentially perfect. High dynamic range High readout speed Threshold Loss Charge sharing noise > Displayed image Image pixel Image pixel Signal from sensor Dead border area These “gaps” in the profile are not visible in the final image, since they...

METALJET X-ray source Microfocus Made Perfect: The IµS 3.0 Together with our partner Incoatec, Bruker pioneered the first modern microfocus sources. More than 750 of these outstanding sources have been installed in the field and have established an unequalled record for performance and reliability. Now, with the new IμS 3.0, we take microfocus technology to the next level. It is the first ever microfocus source completely designed and optimized for crystallography. Other microfocus sources use technology that was designed for radiography or non-destructive testing (NDT). They are good when one...

Goniometer Optics Source Detector Top Performance & Light Footprint With the D8 QUEST and D8 VENTURE, we are following design principles that protect the environment. Our PHOTON II detector and the advanced IμS 3.0 and METALJET sources all feature very low energy consumption and do not need water cooling. This significantly reduces carbon emissions and water consumption, improves reliability, and reduces the cost of ownership. These benefits come with no compromises as all configurations feature unsurpassed performance. *) 24 hours, 300 days with IµS 3.0 and PHOTON II Single-Phase Power The...