Bioprocessing & Bioreactors Reliability and Reproducibility in Mass Flow Control

YOUR Partner for Bioprocessing and Bioreactor Applications Why Bronkhorst? Worldwide representation and service at factory level Widest product portfolio for low flows of gases and liquids Fulfilling bioreactor application requirements Stainless Steel SS316L wetted parts and FDA/USP elastomer sealing Highest accuracy in the market (±0,5% of Reading plus ±0,1% of Full Scale) Widest range of communication interfaces available for MFMs/MFCs on the market Standard and customised instruments to meet customer requirements More than 40 years of experience in bioprocessing & bioreactor applications

We understand bioreactors We provide well-built solutions for bioreactor gas and liquid. Bronkhorst's flow instruments are suitable for benchtop and industrial bioreactors. They are accurate, robust, reliable, and compact. As tailored manifold solutions or open frame installations, they can also be integrated into your equipment. Long-term relationships with major and innovative biotechnology equipment manufacturers have demonstrated that our mass flow controllers are well suited for the job and have strengthened our portfolio with market-specific modifications. Bioreactors are used to produce...

Reliable and reproducible gas control Air, O2, N2, and CO2 are the four most commonly used gases for gassing bioreactors. Bacteria and cells are grown using air and oxygen. Typically, N2 is used to calibrate the pO2 sensor and reduce the O2 content. CO2 is commonly used to control the pH value in the liquid phase. To be able to deliver high-quality biological products over time, optimal conditions inside a bioreactor are required. These conditions can only be maintained if the corresponding process is made reliable and reproducible. Bronkhorst instruments are among the most accurate instruments...

Gas dosing for bioreactors Bacteria are the workhorses of biotechnology, where they are used to create chemically, pharmaceutically, or biologically active substances such as drugs, vaccines and other complex organic molecules. Bacteria have long been used in the production of fermented foods and beverages such as yoghurt and wine. Bacterial habitats are created in bioreactors where bacteria can grow in a controlled environment by conditioning the temperature, gas and liquid concentrations, and pH value. Application requirements Accurate and reproducible dosing of gases such as oxygen or carbon...

Liquid flow control for optimising growth of microorganisms Mammalian cells and microorganisms are being used more than ever before to produce pharmaceuticals and (bio)chemicals. Microorganisms in a bioreactor need liquid nutrients, buffer solutions and reagents. Precise flow control of these liquids ensures consistent growth and controllable results. In case researchers in institutes or industry want to know what conditions cause biological cells to grow faster or slower, flow control of liquid nutrients or other additives can be used to optimise the cell growth. ES-FLOW™ ES-103I Ultrasonic...

SMART maintenance and diagnostics for bioreactors Bronkhorst digital Mass Flow Controllers and Meters provide a variety of parameters for enhanced measurement, control, and diagnostics functionality that is useful in bioreactors. The internal microcontroller primarily supports the device's flow measurement and control functions, as well as digital or analog communication. Additional parameters are implemented for diagnostic purposes, such as use with bioreactors. Bronkhorst instrument parameters can provide useful information for effective integration into maintenance systems, achieving optimal...

Leader in low-flow measurement and control technology Bronkhorst High-Tech is leading in the field low flow fluidics handling technology. We offer an extensive product range of thermal, Coriolis and ultrasonic flow meters and controllers for low flow rates of gases and liquids. Our flow instruments are used for a variety of applications in laboratory, machinery, industrial and hazardous areas. By sharing our knowledge and closely cooperating with OEM customers, we develop customer specific low flow solutions, e.g. of multifunctional, pretested modules or skids for gas, liquid of vapour flow control....