Laboratory bioreactors
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LABORATORY BIOREACTORS

MIST BIOREACTOR SCADA FOR LABORATORY BIOREACTORS FED-BATCH MODEL BASED CONTROL SYSTEM

We are an innovative company designing and manufacturing laboratory and pilot scale bioreactors. Our bioreactors meet up-to-date requirements and includes innovative solutions. Model based control of fed-batch fermentation, as well as the use of novel of magnetic drive are as an example. We test our new bioreactor solutions in our laboratory through real fermentation processes. pr Our bioreactors have been designed in such a way to be easily supplemented and adapted to various applications. We manufacture laboratory bioreactors for cultivation of bacteria, mammalian cells and microalgae,...

Laboratory twin bioreactor EDF-1.2 Laboratory twin bioreactor EDF-1.2 EDF-1.2 is innovative twin bioreactor, designed for both research and process development in fermentation and cell culture. Our twin bioreactor has compact and ergonomic design. Temperature control of the bioreactor vessel is made by innovative temperature control system, equipped with a Peltier element. Consequently, the temperature control is provided without connecting the vessel to the bioreactor cooling water source. Magnetically coupled drive creates good sterility conditions.

Laboratory twin bioreactor EDF-1.2 Technical specification Model Overall dimensions of the bioreactor (mm) The minimum size of the autoclave chamber for vessel autoclaving (mm) Aeration, mixing Aeration, mixing Air supply, including pressure reducer with pressure gauge, flowmeter (air - 2 l/min); ring bubbler; incoming and exhaust gas filters; easy folding exhaust gas condenser Aeration (optionally – for cell cultures) Separate gas or gas mixture supply to the surface of the culture Microsparger MFC for air, O2, N2, CO2 Gas mixing (Air, N2, O2, CO2 ) Top placed motor with novel magnetic...

Laboratory twin bioreactor EDF-1.2 1) Ethernet connection to SCADA PC 2) Ethernet connection to IAN or WAN for remote maintenance 3) WiFi connection (VNC server) for smart phones and tablets Sensors (standard) Temperature, pH, pO2, foam / liquid level Temperature control Heating and cooling is controlled by an innovative system consisting of a Peltier element. Limits of temperature control from 15 °C to 45 °C. Measurement accuracy ± 0,1 °C; accuracy of temperature within the prescribed limits ± 0,2 °C Polarographic sterilizable pO2 sensor (Hamilton or equivalent, length 160 mm). Optionally...

EDF-5.4 is an autoclavable glass bioreactor with working volume till 4,5 l (total volume 6,2 l, inside diameter 150 mm). Laboratory bioreactor EDF-5.4 has two versions: EDF-5.4_1 for cultivation and EDF-5.4_2 for cultivation of mammalian and plants cells. Bioreactor is intended for cultivation of bacteria, yeasts and mycelia cultures. However, bioreactor EDF-5.4 can be adapted for culturing mammalian, stem and plant cells. Depending on the applied microbial culture it is possible to adapt the configuration of the bioreactor in a corresponding way by replacing stirrer and a bubbling system...

Technical specification Model Overall dimensions of the bioreactor (mm) The minimum size of the autoclave chamber for vessel autoclaving (mm) Aeration, mixing Aeration (standard) Supply and mixing two gases (air, O2) to ensure oxygen enrichment, including 2 pressure reducers with pressure gauges; 2 rotameters (for air 0 – 10 l/min for O2 0 - 5 l/min, can be customized to other ranges); microbiological filter; ring sparger (optionally microsparger); inlet gas filter; outlet gas filter with easy bending condenser; membrane valve and filter Aeration (optionally) Separate gas or gas mixture supply...

Laboratory bioreactors EDF-5.4 Communication 1) Ethernet connection to SCADA PC 2) Ethernet connection to IAN or WAN for remote maintenance 3) WiFi connection (VNC server) for smart phones and tablets Sensors (standard) Temperature, pH, pO2 , foam / liquid level Sensors (optionally) Optical density, measuring the weight and volume of feeding components, Redox potential, pCO2, O2 /CO2 gas analysis in the exhaust gas Temperature control Built-in thermostat (heater – 500 W, chamber, recirculation pump, cooling water valve). Temperature control range from 5 °C till 55 °C above the chiller...

Easy bending condensor 13 ports in the lid Wireless control using smartphones and tablet computers Autoclavable sampling device in jacketed bottom of the vessel Fed-batch control using MATLAB (via OPC server

Laboratory bioreactor EDF-15.1 EDF-15.1 is autoclavable glass bioreactor with a working volume of 11 liters (total volume of 16 liters, the internal diameter of 200 mm). Bioreactor is foreseen for culturing bacteria, yeast, and mycelia microorganism cultures. However bioreactor EDF-5.4 can be adapted for culturing mammalian, stem and plant cells. Depending on the applied microbial culture it is possible to adapt the configuration of the bioreactor in a corresponding way by replacing stirrer and a bubbling system complementing aeration gas ga mixing unit (air, O2, N2, CO2). EDF-15.1 has a...

Laboratory bioreactor EDF-15.1 Ports For mixer/agitator drive; for pH, pO2 , T, foam and level sensors; port with three needles for introducing additives to control the pH and foam level; hemostat tube to collect the product; aseptic pierceable membrane port, a port for the incoming gas with a filter of 0,2 micron, the condenser exhaust gas with a filter of 0,2 um, 2 spare ports closed with plugs Bottom lid Metal bottom with jackets for temperature control Autoclavable aseptic sampler Control and management of the culture process Frame of the control unit Made from stainless steel A304,...

The EDF-5.4 monoblock can be adapted for single use bioreactor control. For example, we have experience in application of single use vessels from CerCell (Danmark). Eliminates the necessity to acquire and maintain the infrastructure for the processes (cleaning and sterilisation), which can be critical for validation; CerCell has configurable vessels of different volumes (0,5 to75 liters). These vessels are equipped with all necessary accessories to provide fermentations of different microbial cultures. An important advantage of these vessels is the possibility to achieve high mixer rotation...