Synthesis, Purification, and Evaporation Solutions

Biotage Peptide Synthesizers Overview 3 Biotage® Initiator+ Alstra” 4 Biotage® Initiator Peptide Workstation 20 Biotage Flash Purification Systems 22 Biotage® Star Bio Columns 24 Parallel Peptide Purification 27 32 Technical Specifications 37 Ordering Information Biotage has developed a range of tools to improve the peptide synthesis workflow, designed specifically to improve peptide chemists’ overall laboratory efficiency without compromising peptide quality. Our workflow solutions are used in pharma, biotech, CRO and academic laboratories globally. Peptide Synthesis Workflow | © Biotage 2023...

Peptide Synthesis Workflow Biotage offers a wide range peptide synthesizers for Fmoc solid phase peptide synthesis. Decrease synthesis time using either microwave, for a single peptide, or optional thermal heating blocks for potentially hundreds of peptides in parallel. ® Elevated temperatures increase the speed of amide bond formation. Use high concentration of activated amino acids to increase the rate of amide bond formation. Efficient oscillation or vortex mixing for superior mixing and homogeneous heat distribution. Fully automated peptide synthesizers. Better synthesis results in less chromatography...

Peptide Synthesis Workflow | © Biotage 2023

Biotage Peptide Synthesizers Overview Biotage1 Initiator+ Alstra Heating Block Reactor Vial Sizes (mL)1 Activation .n situ and pre-activation in situ and pre-activation Vessels3 (standard) (standard) (standard) Reagent Bottles External Bottle Positions Microwave Assisted Organic Synthesis (MAOS) Dependent on reactor block configuration. Dependent on reactor vial size, resin type and resin loading. Custom amino acid rack configurations are available, including 96-position deep well plate. Please enquire for more information.

We provide custom peptides supplying standard and exotic peptides, so speed is important but we also need high quality peptides – that’s why we purchased a second Alstra.” Director, CRO, Sweden Biotage Initiator+ Alstra ® Automated Microwave Peptide Synthesizer The Biotage Initiator+ Alstra is a fully automated microwave peptide synthesizer with built in flexibility for both small and large scale synthesis. ® Microwave irradiation is a fast and precise heating method for the synthesis of peptides at elevated temperatures providing dramatic reductions in synthesis time along with an increase in...

Simplicity of operation using the versatile touch screen interface. Flexible rack set-up allows reagents to be positioned anywhere. Cover plates with option to add nitrogen flow over the reagents using the Inert Gas manifold option. Five reagent bottles allowing different coupling reagents and capping steps during a synthesis. The robot liquid handler accurately dispenses the exact amount of reagents required and can dispense as little as 100 μl. Three external system solvents. technology (US 9534011) is superior to nitrogen gas bubbling and ensures homogeneous heat distribution and efficient...

Software Features Biotage Initiator+ Alstra comes with the most user friendly, intuitive and flexible software on the market. ® No need to create methods for each scale. Just input the scale that you want and select the vial size and the methods which adjusts the reagent quantities accordingly. Fully automate all cycles and/or use semi-automated operations where the Fmoc deprotection and washing steps are automated and then manually add expensive building blocks. This gives you complete control over all reaction steps. Easily pause and re-start a synthesis to remove samples, for monitoring and...

“Edit on the Fly” This is a very powerful tool providing the user with even more control during a peptide synthesis run, just like in manual synthesis, and allows the user to: Make changes to a synthesis that is already in progress (after pausing operation). Pause and check a coupling and make changes based on the result without having to reprogram the synthesis, with the additional volume of reagents required adjusted in the calculation table. Make changes to a manual, semi-automated or automated operation. Avoid unnecessary double couplings and easy to implement if required thereby conserving...

Optional Accessories Alstra™ Remote The Alstra™ Remote software provides users the ability to program a complete synthesis setup on their own computer off-line, including calculation of reagents required which can be prepared in advance of a synthesis. The synthesis setup file can then be imported and run on a Biotage® Initiator+ Alstra™ microwave peptide synthesizer. This improves productivity and minimizes turnaround time between consecutive syntheses, which is an important requirement in a multi-user laboratory environment. The Alstra MAOS kit enables Biotage® Initiator+ Alstra™ to be used...

Amino Acid Racks Inert gas can be connected as standard to the microwave cavity on Biotage Initiator+ Alstra systems. However, the inert gas manifold is an optional accessory. When used with the cover plates, it enables nitrogen flow over the reagents on the rack tray, thereby keeping Fmoc amino acids and reagents under an inert atmosphere. Additional amino acid rack options are available for smaller (10 mL) and larger tubes (50 mL). Inert gas manifold includes manifold and regulator. Modular racks allows for flexible reagent setup. Consumables A wide variety of consumables are available for...

The unique U-block reactor assembly has an independent flow path for each reactor vial with no possibility of cross-contamination. Precise digital syringe pumps guarantee low amino acid and reagent consumption, reducing running costs. Efficient vortex mixing gives the best synthesis results. Manually adjust speed control for vortex mixer. Syro I configured with 24-position reactor block. Custom amino acid rack configurations are available. Please enquire for more information. Automated Parallel Peptide Synthesizers Syro I and Syro II systems are fully automated computer controlled peptide synthesizers...