ISOLUTE® Si Trisamine
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ISOLUTE Si Trisamine | Page 1 ® Metal Scavenger Capacity (mmol/g) Shelf Life Thermally & Mechanically Stable Good Laboratory Practice Specifications Chemical Name: Propyl tris-(2-aminoethyl) amine silica Solid-Support Type: Metal scavenging, scavenging acid chlorides, sulfonyl chlorides, isocyanates, chloroformates, anhydrides and other electrophiles Typical Scavenging Conditions: Si-Trisamine (3 equiv.) agitated with metal or electrophile at room temperature for 30 min. Compatible Solvents: Water, acetonitrile, methanol, DMSO, DCM, THF, DMF, Dioxane Figure 1. Metal Scavenging ISOLUTE Si-Trisamine is a silica bound equivalent of a trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanates and heavy metal ions such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Pb+2, Ru+2 and Zn2+. ® Si-Trisamine has a number of uses, it is a very powerful scavenger of transition metals and can also be used as a work-up tool to remove electrophiles or acids in either batch or flow-mode (cartridge) following traditional reflux heated or microwave synthesized reactions. Metal Scavenging Heavy metals such as palladium, copper and tin are widely used in diverse transformations and their removal following organic synthesis has become a vital part of the API scale-up process. Si-Trisamine was applied successfully in the scavenging of palladium acetate, copper sulfate and nickel acetate from aqueous and organic solutions (Figure 1

ISOLUTE Si Trisamine | Page 2 ® Medicinal Chemistry Regular silica Regular silica Sulfonamides and amides are important pharmacophores, commonly synthesized via activation of the corresponding acid followed by reaction with an amine substrate. Si-Trisamine can be used to scavenge the excess activated electrophile, eliminating the need for column chromatography. The use of Si-Trisamine as a scavenger of excess 2,3,4,5,6-pentafluorobenzoyl chloride, benzoyl chloride or p-toluene sulfonyl chloride allowed efficient isolation of a variety of alkylated adducts (Figure 2). Si-Trisamine is...

ISOLUTE' Si Trisamine | Page 3 Ordering Information Quantity Part Number ISOLUTE* Si-Trisamine is included in a comprehensive metal scavenging screening tool kit, an essential tool to quickly and effectively find the right metal scavenger for the application in hand. With protocols, guidance and recommendations, this all in one kit showcases all of the key metal scavengers. Part Number: K-MS-2. Distributors in other regions are listed on www.biotage.com Part Number: PPS372.V.2 © 2023 Biotage. All rights reserved. No material may be reproduced or published without the written permission of...