Flash Purification Systems
24Pages

Instruments Biotage® Isolera™ Spektra One Biotage® Isolera™ Spektra Four Biotage® Isolera™ Spektra LS Biotage® Isolera™ Prime Biotage® FlashMaster Personal Biotage® FlashMaster Personal Plus Flash 75 Flash 150 Flash 400 Accessories ELSD-1080 Dry Loading Vessels Racks Adapters

Powerful, robust, automated flash purification systems Spend your time creating compounds, not purifying them From synthetic route to final compound, Biotage delivers innovative solutions to streamline your entire process, enabling you to reach your purification goals faster and easier. Contents Page Systems Biotage® Isolera™ Product Family 3 Biotage® Isolera™ Spektra One & Four 4 Biotage® Isolera™ Spektra LS 6 Advanced Isolera™ Spektra Features 8 Biotage® Isolera™ Prime 10 Biotage® FlashMaster Personal 12 Biotage® FlashMaster Personal Plus 12 Flash Scale-up Product Family 13 Purification...

Biotage® Isolera™ Family The next generation in flash purification The Biotage Isolera is a family of flash purification systems with intelligent features that enable chemists to easily achieve better separations at scales from milligrams to over 150 g. The new Isolera Spektra enable chemists to purify more compounds in less time and reduce post-process purity analysis. Isolera Spektra doubles chemists' productivity while slashing purification costs 20% or more. Biotage Isolera Spektra Four • Patented, time-saving TLC-to-step gradient included Single channel system ideal for 1 to 2 chemists...

Convenient solvent bottle rack utilizes up to four 4 L bottles. The built-in UV detector provides targeted fraction collection. Large, easy-to-read and use touch screen. Use the TLC-to-gradient feature for optimal purification. A wide range of removable racks accommodates any laboratory need. Quatro-binary gradient capability resolves complex sample mixtures. Biotage Isolera Spektra One and Four ™ Advanced, intelligent features enable better, faster purification The Biotage Isolera flash purification family is designed to help purify synthesis reaction mixtures, natural product extracts,...

• TLC-to-Step gradient Solvent delivery • Gradient Optimization • Real-time PDA scanning • 2D and 3D spectral analysis • Optimized for Biotage® SNAP Ultra cartridges • λ-All detection • Baseline correction • Run counter other Advantages Flow rate Pressure limit Choice of variable wavelength (200–400 nm), fixed (254 nm), or UV-VIS (200–800 nm) detectors Flow cell path length Single/dual/λ-All wavelengths (variable UV and UV-VIS) Fractionation modes Volume, threshold, threshold with volume, low slope, medium slope, custom slope Collection vessels Test tubes (13 mm, 16 mm, 18 mm, and 25 mm)...

Gradient Optimization reduces solvent consumption up to 60%. Built-in sample load pump. Direct scale-up from milligrams to >150 g. Utilizes cartridges from 50 to 1500 g. Removable fraction collection racks and trays. Standard leak detector adds safety. Biotage Isolera Spektra LS (Large Scale) ™ From milligrams to over 150 grams on a single system Biotage Isolera Spektra LS development-scale flash purification system dramatically shortens large-scale purification run-times with flow rates of 50–500 mL/minute. Simply select or create a method, load your sample, and run – it’s that easy....

• TLC-to-Step gradient Solvent delivery HPFC pumps • Gradient Optimization Flow rate Pressure limit 145 psi (10 bar) Choice of variable wavelength (200-400 nm) or UV-VIS (200-800 nm) detector • Optimized for Biotage® SNAP Ultra cartridges Flow cell path length 0.3 mm • λ-All detection • Baseline correction Fractionation modes Volume, threshold, threshold with volume, low slope, medium slope, custom slope other Advantages • Flow rates of 50–500 mL/min • Method evaluation and scale-up on one system • Unique sample loading pump Collection vessels Test tubes (17.5 mm, 18 mm and 25 mm) and...

Advanced Isolera Spektra Features ™ Intelligent functions for fast chromatography Preview your run in the built-in simulator The new TLC-to-Step gradient calculator creates an optimal elution method for separating up to six compounds based on TLC data. Up to 10 solvent ratios and their Rf data can be entered to create the most optimized separation conditions. The resultant dry run simulation can be edited on the touch screen to target a specific peak, which will shorten the purification. In this example, the Isolera Spektra estimates the first compound to elute between 1 and 2 column...

Advanced λ-All detection Current flash purification technology makes use of one or two wavelengths for detecting sample components. However, many compounds being purified have unknown absorbance spectra. The Isolera Spektra λ-All function uses all available wavelengths for compound detection and sums the responses to maximize sensitivity and improve collected compound yield. Now it is possible to see actual spectra for each compound as it elutes from the cartridge – in real-time. This information is used to ensure compound purity and identification. Isolera Spektra brings this technology to...

Convenient solvent bottle rack utilizes up to four 4 L bottles. The built-in UV detector provides targeted fraction collection. Large, easy-to-read and use touch screen. Use the TLC-to-gradient feature for optimal purification. A wide range of removable racks accommodates any laboratory need. Performs both normal- and reversed-phase purification. Biotage Isolera Prime ™ The new standard in value-priced flash purification systems Biotage Isolera Prime is the new standard in value-priced flash purification systems delivering a full range of features and cost-saving benefits. This flexible...

• Solvent-saving Gradient Optimization can reduce solvent use up to 60% Solvent delivery • Upgradeable and flexible • 145 psi (10 bar) pressure capability enables both normal-phase and reversed-phase purification Constant volume electric HPFC pump Flow rate Pressure limit Choice of variable dual-wavelength (200–400 nm) or fixed (254 nm) detector • Patented TLC-to-Gradient feature eliminates method development guessing and re-runs Flow cell path length • Two UV detector options to address different application needs Single wavelength, Dual wavelength (variable UV) Fractionation modes • Holds...