Seamless solutions from bench to plant

Efficiency and reproducibility are critical for successful scale-up. Biotage flash purification solutions are designed for simple and seamless scale up from development to large-scale cGMP manufacturing. Our flash chromatography solutions support a broad range of therapeutics and natural products, including APIs, high-potent APIs, lipids, oligonucleotides, peptides, and novel compounds advancing materials science. • Easy setup - Intuitive, modular systems • Seamless scaling - Scale up methods easily and minimize solvent use and waste • Flexible choices - Select the right column and silica • High...

Large Scale Flash Purification | © Biotage 2025

• Optimize loading, compound purity and yield with intuitive software • Minimize solvent usage and waste with advanced software • Simplifies and bullet proofs the process of scaling up • Achieve reproducibility in manufacturing with simple methods scale-up from the development phase • Enhance operational safety with pre-packed plug-and-play columns, minimizing risks with potent drug compounds • Documentation to support use or validation in regulated production environments

Large Scale Flash Purification | © Biotage 2025

Complete flash purification family Biotage Selekt Development & production Maximum sample size – normal-phase (g) Flow rate (mL/min.) Nominal cartridge mass Level of automation * With pressure releasing safety valve kit P/N 417115SP for cartridges with CV > 0.8 L (i.e. >340 g).

Large Scale Flash Purification | © Biotage 2025

Flexible media options and scalable column sizes Our wide selection of media and columns provides flexibility and reliability for your process. Using the same media from 5 g to 48 kg in pre-packed columns—from development to manufacturing—ensures consistent packing, performance and results. This approach eliminates open media handling, supporting safer operations. Scalable column options Biotage Sfär Nominal silica mass: 5 g-400 g Nominal silica mass: 750 g-1850 g Biotage Selekt

Large Scale Flash Purification | © Biotage 2025 Stationary phase guide Phase Media Particle size range (pm)

Large Scale Flash Purification | © Biotage 2025

Your complete partner for effective chemistry Biotage is a worldwide supplier of instruments and accessories designed to facilitate the work of laboratory and process chemists. With our deep knowledge of the industry, academic contacts and in-house R&D teams, we can deliver the best solutions to your challenges. We take great pride in our flexibility and ability to meet our customer’s individual needs. With strong foundations in both analytical, organic and process chemistry, we can offer the widest range of solutions available on the market. For local office contact information, visit biotage.com/contact...