besec

besec

besec

Product catalog summary
Introduction
The BeSEC Series is an advanced light scattering detector designed for SEC/GPC systems, offering absolute molecular weight analysis. It enhances traditional chromatography workflows by providing first-principles data, crucial for fields like biopharmaceuticals and polymer science.

Key Features
  • Dual detection angles (7° and 90°) for accurate molecular weight and size analysis.
  • Molecular weight range from 1 kDa to 2 GDa.
  • Supports radius of gyration (Rg) > 12 nm.
  • Compatible with homopolymer and protein modes.
  • Real-time analysis with intuitive software.
  • 18 μL flow cell to minimize band broadening.

Benefits
  • Eliminates inaccuracies of traditional column calibration.
  • Direct measurement with low-angle (LALS) and right-angle (RALS) light scattering.
  • High accuracy for large macromolecules and sensitivity for small ones.

Universal Integration
The BeSEC Series integrates seamlessly with any SEC/GPC system, enhancing workflows by combining detectors like RI, UV, and light scattering for real-time molecular characterization.

Static Light Scattering Technology
Utilizes Rayleigh scattering to correlate scattered intensity with molecular weight and the second virial coefficient, providing precise molecular characterization.

Advantages Over Conventional Methods
  • Direct molecular weight measurement without calibration curves.
  • Independent of retention time, avoiding biases of traditional methods.
  • Accurate distinction between polymers with similar hydrodynamic sizes.

Software and User Experience
The BeSEC software offers a user-friendly interface with features like automated sequence measurements, multi-peak integration, and comprehensive statistical reports.

Application Examples
  • Proteins & Biologics: Distinguishes and quantifies monomers, dimers, and aggregates, crucial for formulation stability.
  • Polymers & Plastics: Provides complete molecular weight distribution, aiding in process control and product optimization.

Specifications
  • Molecular weight range: 1 kDa to 2 GDa.
  • Detection angles: RALS (90°), LALS (7°).
  • Compatible with aqueous and organic solvents.
  • Dimensions: 450 × 325 × 157 mm; Weight: 11 kg.

Contact Information
Bettersize Instruments Ltd., China and Bettersize Inc., USA. Visit their website for more information.
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Catalog excerpts

besec-1

ABSOLUTE MOLECULAR WEIGHT MOLECULAR WEIGHT DISTRIBUTION MOLECULAR SIZE BeSEC Series Absolute Insight into Every Molecule Bettersize BETTER PARTICLE SIZE SOLUTIONS

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Step into the future of chromatography with the BeSEC Series. Designed as a next-generation light scattering detector, the BeSEC transforms conventional SEC/GPC workflows into powerful platforms for absolute molecular weight analysis. Unlike traditional methods that rely on retention time, the BeSEC delivers first-principles data, ensuring unmatched accuracy for researchers in biopharmaceuticals, advanced polymer science, and food chemistry-accelerating the path from discovery to market. Features • Dual detection angles: 7° and 90° • Molecular weight range: 1 kDa to 2 GDa • Supports radius of...

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Universal Integration Coupling with Any SEC/GPC Platform Seamlessly SEC/GPC Analytical Workflow The BeSEC Series is engineered for universal compatibility, allowing seamless integration downstream of any third-party SEC/GPC system. delivery pump, inline degasser, autosampler or manual injector, and SEC columns; and the detection stage, Front-End Separation Devices which employs a combination of detectors—most commonly Refractive Index (RI), UV-Visible, and Light Needle Wash Bottle Scattering—to characterize molecular properties in real time. Mobile phase Pump Six-port valve Mobile Phase Sample...

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Determining Absolute Molecular Weight Breaking Free from Column Calibration In size exclusion chromatography (SEC), separation depends only on the hydrodynamic size of the molecules. Larger molecules are unable to penetrate the pores of the stationary phase and elute earlier, while smaller molecules enter the pores and elute later. The separation mechanism is purely physical, and no chemical or adsorptive interactions occur between the solute and the stationary phase. Traditional SEC/GPC systems without light scattering detection provide only relative molecular weight Conventional methods that...

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BeSEC software is a dedicated chromatography workstation for light scattering detectors. It features a clear, user-friendly interface and straightforward operation, and delivers a wide range of application-specific reports and results. Features & Benefits • Compatible with any third-party GPC or SEC system, acquiring RI, UV, and start signals • Supports automated sequence measurements • Enables reliable multi-peak integration • Allows baseline and integration settings across all detector signals simultaneously • Provides dn/dc determination and concentration calculation • Offers statistical reports...

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Specifications Polymers & Plastics Molecular weight plays a critical role in determining both the mechanical strength and processing behavior of polymers such as PET. Traditional methods like intrinsic viscosity provide only an average value and fail to reveal the complete molecular weight distribution. By integrating light scattering signals with an SEC system, researchers can directly measure absolute molecular weight and resolve the full distribution. This capability supports improved process control and product optimization, ensuring consistent quality and performance. Proteins & Biologics...

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Bettersize Instruments Ltd. No. 9, Ganquan Road, Jinquan Industrial Park, Dandong, Liaoning, China Postcode: 118009 Tel: +86-755-26926582 Bettersize Inc. 3185 Airway Ave, Suite C2, Costa Mesa, CA 92626, United States Tel: +1 833-699-7493 (SIZE) [email protected] www.bettersizeinstruments.com Visit Our BeSEC Site Visit Our Official YouTube Channel Disclaimer: By using or accessing any materials provided by Bettersize Instruments Ltd. in electronic format, you agree to the Disclaimer without any qualification or limitation. While diligent care has been taken to ensure the accuracy of the information...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.
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