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Process Technology for Pharmaceutical Applications

Process Technology for Pharmaceutical Applications
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Process Technology for Pharmaceutical Applications - 1

Process Technology for Pharmaceutical Applications PHARMA & COSMETICS a Business Field of NETZSCH Grinding & Dispersin

Process Technology for Pharmaceutical Applications - 2

Grinding and Dispersing for Pharmaceutical Applications Pharmaceutical manufacturing processes require the utmost care and precision - from initial laboratory testing to full-scale production. In this tightly regulated industry, every step in the production process demands precision pharmaceutical-grade machinery. NETZSCH understands special pharmaceutical requirements and respects your confidentiality. When working with high-quality, high-cost materials, there is no room for error or loss. There are standards: safe, cost-effective, easy-to-clean equipment that provides precise,...

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Advantages of Milling API’s NETZSCH Competency The Advantage of Ultra Fine Particles More than 90% of drugs approved since 1995 have poor solubility, poor permeability, or both. Drug performance can be improved by reducing the particle size and at the same time increasing the specific surface area of the active pharmaceutical ingredients (API). With almost half of new chemical entities (NCEs) impaired by poor water solubility, ultra fine particles are the solution. Reducing drug particles to nano size increases their surface area and subsequent solubility dramatically. Nanoparticles are...

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Process Technology for Pharmaceutical Applications - 5

DeltaVita® Technology The NETZSCH engineered DeltaVita® mill, based on proven Zeta® Mill technology, stands out in the world of ultra-fine nanoparticle applications. Through the efficient use of energy, high flow-rate, multiple-pass grinding strategy, DeltaVita® mills achieve excellent repeatability as well as homogeneous dispersion. DeltaVita® mills are fast, extremely versatile and designed to produce a very narrow range of ultra fine particles in a homogeneous formulation. In the time it takes for an ordinary mill to complete one pass, DeltaVita® mills cycle through as many as 10...

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DeltaVita® – Laboratory and Pilot Plant Sized Machines DeltaVita® 15 - 300 R&D in small batches is an essential part of the new drug development process. The market demands the ability to confirm process feasibility without wasting scarce, costly materials. NETZSCH provides it. NETZSCH’s laboratory equipment is ideal for testing where only the smallest batch sizes are needed to achieve significant test results with minimal product loss in a short period of time. NETZSCH’s laboratory equipment offers: Repeatable results batch after batch Scalability to full-size production equipment Easy to...

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The DeltaVita® 600 provides the ready solution with batch sizes of 1 liters to 6 liters to support clinical trial phase. Features ■ Interchangeable agitating systems ■ Optional explosion-proof design for installation in hazardous areas ■ PLC control with optional interface for data acquisition ■ Optional CIP and SIP ready Grinding chamber volume Drive power Speed range Batch size (min.-max. suggested) Grinding media diameter

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DeltaVita® 2000 - 60000 DeltaVita® range is scalable from the DeltaVita® 300 to full scale production batches up to 4 000 liters. The production systems are offered in two frame designs. The flexible portable design is a complete machine located within the process suite. The fixed installation option is a split frame design with all mechanical components outside the clean room and only the wetted components in the process suite. Eigenschaften ■ Fully CIP and SIP capable PLC control ■ Optional data recording and process formulation management Double acting mechanical seal ■ Choice of wetted...

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Materials & Surface Finish Stainless steel with surface finish of Ra = 0.4 µm High tech and high strength ceramic materials for metal contamination free processing - NETZSCH-Ceram A - NETZSCH-Ceram Z - NETZSCH-Ceram C - NETZSCH-Ceram N All wetted parts can be sterilized with SIP or autoclave (depending on machine size) Food / pharma grade elastomers and lubricants NETZSCH DeltaVita® 10000 produc

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Process Technology for Pharmaceutical Applications - 10

ConJet® High Density Bed Jet Mill The ConJet® High Density Bed Jet Mill is a spiral jet mill design with an internal dynamic air classifier. The variable speed classifier can micronize to 1 pm to 40 pm with infinite control and precision without oversize particles. Features ■ Operates practically residue-free at the end of the process making ideal for processing high value materials ■ Low energy use and high fineness ■ Choice of product contact parts ■ Stainless steel with surface finish of Ra = 0.6 pm ■ High tech and high strength ceramic materials for metal contamination free processing...

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Process Technology for Pharmaceutical Applications - 11

Condux® Impact Mill The Condux® Impact Mill can be used for a wide range of applications in the pharmaceutical industry. It can be equipped with various grinding tools and stators, to optimize any process. The Condux® Impact Mill combines all the advantages of modern grinding technology in a practical, flexible and highly-efficient machine design. ■ Exchangeable grinding elements for versatility ■ Size reduction to d50 ~ 20 qm to 500 qm ■ Pin discs for size reduction by impact ■ Counter-rotating pin discs for the highest fineness possible ■ Blast rotor and wing beater for size reduction by...

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Additional Machinery CFS/HD-S High Dispersion Air Classifier Air classification of pharmaceutical materials can enhance or even replace micronization in some applications. Air classifiers are used to modify particle size distributions. The CFS/HD-S is a modern air classifier that can provide cut sizes in the range of 1 μm to 40 μm with infinite control and precision. High dispersion takes place in near proximity to the classifier wheel for effectively separation No intermixing of fine or coarse material with new feed material High yield Lowest possible pressure drop for low energy use...

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NETZSCH Vacuum De-Aerator In the NETZSCH Vacuum De-Aerator, micronized gases are removed from fluids with a wide range of viscosities. By means of the VTR Principle (vacuum - thin-film - rotary process), it is possible to process products from topical gels and creams, for example, to a wide variety of free-flowing compounds. The throughput is product and viscosity dependent and can range from 500 kg/h to 4 000 kg/h. This machine can be used to de-gas both small quantities, from interchangeable tanks in batch operation, and large batches in continuous operation. NETZSCH Vacuum De-Aerator DA...

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